cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2020-35-3-38-46cardiotomsk-1037Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESСостав и метаболическая активность микробиоты пищеварительной системы у детей и подростков с ожирениемComposition and metabolic activity of the gut microbiota in obese children and adolescentshttps://orcid.org/0000-0002-2667-4842СамойловаЮ. Г.SamoilovaJu. G.

Самойлова Юлия Геннадьевна, доктор медицинских наук, профессор кафедры эндокринологии и диабетологии, заведующий кафедрой детских болезней, СибГМУ, руководитель Центра клинических исследований, Главный специалист Департамента здравоохранения Томской области по медицинской профилактике 

634050, Томск, Московский тракт, 2

Julia G. Samoilova Dr. Sci. (Med.), Professor, Department of Endocrinology and Diabetology, Head of the Department of Children’s Diseases, Head of Clinical Research Center, Siberian State Medical University; Leading Specialist for Prevention, Department of Healthcare of the Tomsk Region Administration

2, Moscovsky tract, Tomsk, 634050, Russian Federation

https://orcid.org/0000-0002-2915-384XОлейникО. А.OleynikO. A.

Олейник Оксана Алексеевна, кандидат медицинских наук, доцент кафедры эндокринологии и диабетологии, эксперт Центра клинических исследований

634050, Томск, Московский тракт, 2

Oxana A. Oleynik, Cand. Sci. (Med.), Associate Professor, Department of Endocrinology and Diabetology

2, Moscovsky tract, Tomsk, 634050, Russian Federation

oleynikoa@mail.ruhttps://orcid.org/0000-0002-5434-4429СаганЕ. В.SaganE. V.

Саган Елена Викторовна, ассистент, кафедра детских болезней

634050, Томск, Московский тракт, 2

Elena V. Sagan, Assistant Professor, Department of Children’s Diseases 

2, Moscovsky tract, Tomsk, 634050, Russian Federation

aghan1982@mail.ruhttps://orcid.org/0000-0002-1610-0896ВорожцоваИ. Н.VorozhtsovaI. N.

Ворожцова Ирина Николаевна, доктор медицинских наук, профессор, заведующий кафедрой эндокринологии и диабетологии

634050, Томск, Московский тракт, 2

Irina N. Vorozhtsova, Dr. Sci. (Med.), Professor, Head of the Department of Endocrinology and Diabetology 

2, Moscovsky tract, Tomsk, 634050, Russian Federation

abv@mail.tomsknet.ruhttps://orcid.org/0000-0001-6423-7187ФилипповаТ. А.FilippovaT. A.

Филиппова Татьяна Александровна, ассистент, кафедра детских болезней

634050, Томск, Московский тракт, 2

Irina N. Vorozhtsova, Dr. Sci. (Med.), Professor, Head of the Department of Endocrinology and Diabetology 

2, Moscovsky tract, Tomsk, 634050, Russian Federation

fta82@mail.ruhttps://orcid.org/0000-0003-1025-1674ДенисовН. С.DenisovN. S.

Денисов Никита Сергеевич, студент

634050, Томск, Московский тракт, 2

Nikita S. Denisov, Medical Student 

2, Moscovsky tract, Tomsk, 634050, Russian Federation

denisov.ssmu@gmail.comhttps://orcid.org/0000-0001-8667-9306ДьяковД. А.DyakovD. A.

Дьяков Денис Александрович, ассистент, кафедра общей биохимии и молекулярной биологии с курсом клинической лабораторной диагностики

634050, Томск, Московский тракт, 2

Denis A. Dyakov, Assistant Professor, Department of General Biochemistry and Molecular Biology with Course of Clinical Laboratory Diagnostics 

2, Moscovsky tract, Tomsk, 634050, Russian Federation

den66431511@yandex.ruСибирский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияSiberian State Medical UniversityRussian Federation2020161020203533846Copyright © Самойлова Ю.Г., Олейник О.А., Саган Е.В., Ворожцова И.Н., Филиппова Т.А., Денисов Н.С., Дьяков Д.А., 20202020Самойлова Ю.Г., Олейник О.А., Саган Е.В., Ворожцова И.Н., Филиппова Т.А., Денисов Н.С., Дьяков Д.А.Samoilova J.G., Oleynik O.A., Sagan E.V., Vorozhtsova I.N., Filippova T.A., Denisov N.S., Dyakov D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/1037

В представленном обзоре обобщены данные современных отечественных и зарубежных исследований о количественном и качественном составе микробиоты кишечника в норме, о доминировании определенных бактерий в микробиоте кишечника детей с ожирением и о связи развития ожирения у детей с изменениями состава и метаболической активности микробиоты кишечника. Эти сведения представляют научный интерес с точки зрения поиска новых мишеней и схем консервативного воздействия с целью профилактики ожирения и его терапии через восстановление микрофлоры желудочно-кишечного тракта.

This review summarizes the results from national and international studies regarding the quantitative and qualitative composition of intestinal microbiota in health and the dominance of certain bacteria in the intestinal microbiota of obese children. Moreover, we discuss the relationships between the development of obesity and the changes in the composition and metabolic activity of intestinal microbiota in children. These analyses are of scientific interest from the perspective of finding new targets and approaches to conservative management aimed at preventing and treating obesity through the restoration of intestinal microflora.

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The authors declare that there are no conflicts of interest present.