cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2020-35-3-47-52cardiotomsk-1038Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESПатоморфология новой коронавирусной инфекции COVID-19Pathomorphology of a new coronavirus infection COVID-19https://orcid.org/0000-0002-6813-3374ЛобановаО. А.LobanovaO. A.

Лобанова Ольга Андреевна, студентка 4-го курса лечебного факультета

119991, Москва, ул. Трубецкая, 8, стр. 2

Olga A. Lobanova, 4th year student, Faculty of Medicine

p. 2, 8, Trubetskaya str., Moscow, 119991, Russian Federation

lobanova.98@mail.ruhttps://orcid.org/0000-0002-9062-8031ТрусоваД. С.TrusovaD. S.

Трусова Дарья Сергеевна, студентка 4-го курса лечебного факультета

119991, Москва, ул. Трубецкая, 8, стр. 2

Daria S. Trusova, 4th year student, Faculty of Medicine

p. 2, 8, Trubetskaya str., Moscow, 119991, Russian Federation

trusov98@yandex.ruhttps://orcid.org/0000-0002-0000-1439РуденкоЕ. Е.RudenkoE. E.

Руденко Екатерина Евгеньевна, ассистент кафедры патологической анатомии имени академика А.И. Струкова, врач-патологоанатом

119991, Москва, ул. Трубецкая, 8, стр. 2

Ekaterina E. Rudenko, Assistant Professor, Pathologist, Department of Pathological Anatomy named after Academician A.I. Strukov

p. 2, 8, Trubetskaya str., Moscow, 119991, Russian Federation

redikor2@yandex.ruhttps://orcid.org/0000-0002-5851-2768ПроценкоД. Д.ProtsenkoD. D.

Проценко Дмитрий Дмитриевич, кандидат медицинских наук, ассистент кафедры патологической анатомии имени академика А.И. Струкова

119991, Москва, ул. Трубецкая, 8, стр. 2

Dmitry D. Protsenko, Cand. Sci. (Med.), Assistant Professor, Department of Pathological Anatomy named after Academician A.I. Strukov

p. 2, 8, Trubetskaya str., Moscow, 119991, Russian Federation

chief@medprint.ruhttps://orcid.org/0000-0002-1107-3753КоганЕ. А.KoganE. A.

Коган Евгения Алтаровна, доктор медицинских наук, профессор кафедры патологической анатомии имени академика А.И. Струкова, врач-патологоанатом

119991, Москва, ул. Трубецкая, 8, стр. 2

Eugenia A. Kogan, Dr. Sci. (Med.), Pathologist, Professor, Department of Pathological Anatomy named after Academician A.I. Strukov

p. 2, 8, Trubetskaya str., Moscow, 119991, Russian Federation

koganevg@gmail.ruПервый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation2020171020203534752Copyright © Лобанова О.А., Трусова Д.С., Руденко Е.Е., Проценко Д.Д., Коган Е.А., 20202020Лобанова О.А., Трусова Д.С., Руденко Е.Е., Проценко Д.Д., Коган Е.А.Lobanova O.A., Trusova D.S., Rudenko E.E., Protsenko D.D., Kogan E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/1038

11 марта 2020 г. Всемирная организация здравоохранения объявила коронавирусную инфекцию 2019 (COronaVIrus Disease 2019 – COVID-19) пандемией. Несмотря на большое количество научных публикаций, касающихся клинической картины и методов лечения, данных о структурных изменениях внутренних органов при COVID-19 недостаточно. В настоящем обзоре представлено и проанализировано несколько клинических случаев, опубликованных учеными различных стран. Инфекция COVID-19 вызвана коронавирусом тяжелого острого респираторного синдрома 2 (Severe acute respiratory syndrome-related coronavirus 2 – SARS-CoV-2), тропным к рецептору ангиотензинпревращающего фермента 2 (ACE2). Взаимодействие с этим рецептором является начальным звеном патогенеза. Морфологическая картина сходна с пневмониями, вызванными SARS-CoV и коронавирусом ближневосточного респираторного синдрома (Middle East respiratory syndrome coronavirus – MERS-CoV): на начальной стадии развивается картина шоковых легких, в последующем она завершается фиброзом и организующейся пневмонией. Одним из наиболее тяжелых осложнений является острый респираторный дистресс-синдром (ОРДС), который наблюдается в некоторых рассмотренных клинических случаях. В настоящей статье мы собрали случаи клинических и морфологических исследований пациентов с COVID-19, опубликованные в англоязычной медицинской литературе на данный момент.

On March 11, 2020, the World Health Organization declared COVID-19 apandemic. Despite a large number of scientific publications concerning the clinical picture and trea tment methods, data on structural changes of internal organs in COVID-19 is still insufficient. This review presents and analyzes several clinical cases published by research groups in various countries. COVID-19 infection is caused by a SARS-CoV-2 virus that binds to the angiotensin-converting enzyme 2 ACE2 receptor. Interaction with this receptor is the initial stage of pathogenesis. The morphological picture is similar to pneumonia caused by SARS-CoV and MERS-CoV: at the initial stage, a picture of shock lungs develops, later it ends in fibrosis and organizing pneumonia. One of the most severe complications is acute respiratory distress syndrome, which is observed in some clinical cases reviewed. In this article, we collected cases of clinical and morphological studies of patients with COVID-19, published in international peer-reviewed medical literature to date.

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Proceedings of the National Academy of Sciences. 2001;98(11):6360–6365. DOI: 10.1073/pnas.111583198.Pushkarsky T., Zybarth G., Dubrovsky L., Yurchenko V., Tang H., Guo H. et al. CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A. Proceedings of the National Academy of Sciences. 2001;98(11):6360–6365. DOI: 10.1073/pnas.111583198.Yurchenko V., Constant S., Eisenmesser E., Bukrinsky M. Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics. Clinical &Experimental Immunology. 2010;160(3):305–317. DOI: 10.1111/j.1365-2249.2010.04115.x.Yurchenko V., Constant S., Eisenmesser E., Bukrinsky M. Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics. Clinical &Experimental Immunology. 2010;160(3):305–317. DOI: 10.1111/j.1365-2249.2010.04115.x.Yurchenko V., Constant S., Eisenmesser E., Bukrinsky M. Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics. Clinical &Experimental Immunology. 2010;160(3):305–317. DOI: 10.1111/j.1365-2249.2010.04115.x.Yurchenko V., Constant S., Eisenmesser E., Bukrinsky M. Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics. Clinical &Experimental Immunology. 2010;160(3):305–317. DOI: 10.1111/j.1365-2249.2010.04115.x.Muramatsu T. Basigin: A multifunctional membrane protein with an emerging role in infections by malaria parasites. Expert Opin. Ther. Targets. 2012;16(10):999–1011. DOI: 10.1517/14728222.2012.711818.Muramatsu T. Basigin: A multifunctional membrane protein with an emerging role in infections by malaria parasites. Expert Opin. Ther. Targets. 2012;16(10):999–1011. DOI: 10.1517/14728222.2012.711818.Muramatsu T. Basigin: A multifunctional membrane protein with an emerging role in infections by malaria parasites. Expert Opin. Ther. Targets. 2012;16(10):999–1011. DOI: 10.1517/14728222.2012.711818.Muramatsu T. 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The authors declare that there are no conflicts of interest present.