cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2021-36-2-23-29cardiotomsk-1187Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESЭндотелиальные прогениторные клетки: происхождение и роль в ангиогенезе при сердечно-сосудистой патологииEndothelial progenitor cells: Origin and role of angiogenesis in cardiovascular diseaseshttps://orcid.org/0000-0003-4524-8491ДенисенкоО. А.DenisenkoO. A.

Денисенко Ольга Анатольевна, врач клинической лабораторной диагностики

634045, Российская Федерация, Томск, ул. Вершинина, 45

Olga A. Denisenko, Doctor of Clinical Laboratory Diagnostics

45, Vershinin str., Tomsk, 634045, Russian Federation

olga-muraveinik@yandex.ruhttps://orcid.org/0000-0003-3468-6154ЧумаковаС. П.ChumakovaS. P.

Чумакова Светлана Петровна, д-р мед. наук, профессор кафедры патофизиологии

634050, Российская Федерация, Томск, Московский тракт, 2

Svetlana P. Chumakova, Dr. Sci. (Med.), Professor, Department of Pathophysiology

2, Moskovsky tract, Tomsk, 634050, Russian Federation

chumakova_s@mail.ruhttps://orcid.org/0000-0002-9457-8879УразоваО. И.UrazovaO. I.

Уразова Ольга Ивановна, д-р мед. наук, профессор, чл.-корр. РАН, заведующий кафедрой патофизиологии; профессор кафедры комплексной информационной безопасности электронно-вычислительных систем

634050, Российская Федерация, Томск, Московский тракт, 2

634050, Российская Федерация, Томск, пр. Ленина, 40

Olga I. Urazova, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Pathophysiology; Professor, Department of Complex Information Security of Computer Systems

2, Moskovsky tract, Tomsk, 634050, Russian Federation

40, Lenin ave., Tomsk, 634050, Russian Federation

urazova72@yandex.ruТомский региональный центр кровиРоссияTomsk Regional Blood CenterRussian FederationСибирский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияSiberian State Medical UniversityRussian FederationСибирский государственный медицинский университет Министерства здравоохранения Российской Федерации; Томский государственный университет систем управления и радиоэлектроникиРоссияSiberian State Medical University; Tomsk State University of Control Systems and RadioelectronicsRussian Federation2021300620213622329Copyright © Денисенко О.А., Чумакова С.П., Уразова О.И., 20212021Денисенко О.А., Чумакова С.П., Уразова О.И.Denisenko O.A., Chumakova S.P., Urazova O.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/1187

Эндотелиальные прогениторные клетки (EPC) – это клетки-предшественницы, обеспечивающие поддержание целостности эндотелия и его восстановление после повреждения сосудов. Показано, что EPC могут дифференцироваться в зрелые эндотелиальные клетки, а также способны продуцировать различные регуляторные ростовые факторы и цитокины. Существует множество исследований связи между ишемической болезнью сердца (ИБС) и циркулирующими EPC. Однако до сих пор остается затруднительным применение EPC для разработки алгоритмов диагностики и лечения сердечно-сосудистых заболеваний (ССЗ). В представленном обзоре обобщены данные о подтипах EPC, методах их получения, биологических характеристиках клеточных популяций и факторах мобилизации к месту повреждения при ССЗ.

Endothelial progenitor cells (EPCs) are the cells that play a key role in maintaining vascular integrity and repairing endothelial damage. It has been shown that EPCs can differentiate into mature endothelial cells and are also capable of producing various regulatory growth factors and cytokines. There are many studies focusing on the associations between coronary artery disease and circulating EPCs. However, it is still challenging to use EPCs for the development of diagnostic and treatment algorithms in cardiovascular diseases. This review presents data on EPCs subtypes, methods for obtaining them, biological characteristics of cell populations, and the factors of EPCs mobilization to the site of injury in cardiovascular diseases.

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The authors declare that there are no conflicts of interest present.