cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2021-36-4-37-44cardiotomsk-1281Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESСовременные исследования генетики многофакторных заболеваний, связанных с нарушением когнитивных функций человекаRecent studies of the genetics of complex diseases associated with impaired cognitive functionshttps://orcid.org/0000-0003-2690-8802БочароваА. В.BocharovaA. V.

 младший научный сотрудник, лаборатория эволюционной генетики

 634050, Российская Федерация, Томск, ул. Набережная реки Ушайки, 10 

 Junior Research Scientist, Laboratory of Evolutionary Genetics

 10, Ushaika River Embankment str., Tomsk, 634050, Russian Federation 

anna.bocharova@medgenetics.ruhttps://orcid.org/0000-0002-5166-331XСтепановВ. А.StepanovV. A.

 д-р биол. наук, профессор, чл.-корр. РАН, директор Томского национального исследовательского медицинского центра Российской академии наук; профессор кафедры генетики и клеточной биологии, Институт биологии, экологии, почвоведения, сельского и лесного хозяйства, Национальный исследовательский Томский государственный университет. 

 634050, Российская Федерация, Томск, ул. Набережная реки Ушайки, 10 

 Dr. Sci. (Biol.), Professor, Corresponding Member of the Russian Academy of Sciences, Director; Professor, Department of Genetics and Cell Biology, Institute of Biology, Ecology, Soil Science, Agriculture, and Forestry, National Research Tomsk State University 

 10, Ushaika River Embankment str., Tomsk, 634050, Russian Federation 

vadim.stepanov@medgenetics.ruНаучно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наукРоссияTomsk National Research Medical Center, Russian Academy of Sciences Russian FederationНаучно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наукРоссияTomsk National Research Medical Center, Russian Academy of SciencesRussian Federation2021010120223643744Copyright © Бочарова А.В., Степанов В.А., 20222022Бочарова А.В., Степанов В.А.Bocharova A.V., Stepanov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/1281

 В представленной работе обобщены данные современных исследований, связанных с поиском генетической компоненты широко распространенных социально  значимых заболеваний, которые приводят к нарушениям  когнитивных функций человека. Основное внимание уделено таким патологиям многофакторной природы, как шизофрения (ШЗ) и болезнь Альцгеймера (БА). В статье приводится подробный анализ широкого спектра методов  современной генетики: от близнецовых до эпигенетических исследований. 

 The present work summarizes data of recent studies related to the search for the genetic component of complex diseases leading to impaired cognitive functions. The main attention is paid to such pathologies as schizophrenia and Alzheimer’s disease. The article provides a detailed analysis of a wide range of modern genetics methods: from twin studies to epigenetic research. 

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The authors declare that there are no conflicts of interest present.