cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2015-30-1-16-21cardiotomsk-136Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРоль воспаления в развитии нарушений ритма и проводимостиThe role of inflammation in heart rhythm and conduction disturbancesГупалоЕлена МихайловнаGupaloE. M.eleno4ka_g@mail.ruМироноваНаталия АлександровнаMironovaN. A.noemail@neicon.ruМалкинаТатьяна АнатольевнаMalkinaT. A.noemail@neicon.ruПолеваяТатьяна ЮльевнаPolevayaT. Yu.noemail@neicon.ruГолицынСергей ПавловичGolitsynS. P.noemail@neicon.ruФедеральное государственное бюджетное учреждение "Российский кардиологический научно-производственный комплекс"РоссияFederal State Budgetary Institution "Russian Cardiology Research-and-Production Complex" of the Ministry of Healthcare of the Russian FederationRussian Federation2015060920163011621Copyright © Гупало Е.М., Миронова Н.А., Малкина Т.А., Полевая Т.Ю., Голицын С.П., 20162016Гупало Е.М., Миронова Н.А., Малкина Т.А., Полевая Т.Ю., Голицын С.П.Gupalo E.M., Mironova N.A., Malkina T.A., Polevaya T.Y., Golitsyn S.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/136

В обзоре освещаются патогенетические механизмы, лежащие в основе идиопатических нарушений ритма сердца (НРС) и проводимости. Основное внимание уделяется роли различных компонентов воспалительного поражения миокарда, в частности, аутоиммунных факторов и фиброзирования. Выявление потенциально обратимых аутоиммунных или воспалительных факторов патогенеза нарушений проводимости сердца может являться определяющим в прогнозировании развития заболевания у подобной категории больных и служить поводом для более тщательного наблюдения за этими пациентами, а также быть мишенью для новых лечебных подходов.

This article reviews pathogenic mechanisms that underlie idiopathic cardiac rhythm and conduction disturbances. It focuses on the role of the various components of the inflammatory response of the myocardium, particularly on the autoimmune factors and fibrosis. Identification of potentially reversible autoimmune or inflammatory factors in the pathogenesis of cardiac conduction disturbances may be useful in predicting the development of the disease, serve as a rationale for more careful monitoring of these patients, and may become a target for new therapeutic approaches.

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The authors declare that there are no conflicts of interest present.