cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2023-38-1-28-36cardiotomsk-1599Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESЦерамиды: взаимосвязь с факторами риска сердечно-сосудистых заболеванийCeramides: correlation with cardiovascular risk factorshttps://orcid.org/0000-0003-3996-3325БеликЕ. В.BelikE. V.

Белик Екатерина Владимировна - кандидат медицинских наук, научный сотрудник, лаборатория исследований гомеостаза, отдел экспериментальной медицины.

650002, Кемерово, Сосновый бульвар, 6

Ekaterina V. Belik - Cand. Sci. (Med.), Research Scientist, Laboratory for Homeostasis Research, Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases.

6, Sosnovy bulvar, Kemerovo, 650002

sionina.ev@mail.ruhttps://orcid.org/0000-0002-6890-3287ДылеваЮ. А.DylevaYu. A.

Дылева Юлия Александровна - кандидат медицинских наук, старший научный сотрудник, лаборатория исследований  гомеостаза,  отдел экспериментальной медицины.

650002, Кемерово, Сосновый бульвар, 6

Yulia A. Dyleva - Cand. Sci. (Med.), Senior Research Scientist, Laboratory for Homeostasis Research, Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases.

6, Sosnovy bulvar, Kemerovo, 650002

dyleva87@yandex.ruhttps://orcid.org/0000-0002-7780-829XГруздеваО. В.GruzdevaO. V.

Груздева Ольга Викторовна - доктор медицинских наук, профессор РАН, заведующий лабораторией исследований гомеостаза, отдел экспериментальной медицины.

650002, Кемерово, Сосновый бульвар, 6

Olga V. Gruzdeva - Dr. Sci. (Med.), Professor of Russian Academy of Sciences, Head оf the Laboratory for Homeostasis Research, Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases.

6, Sosnovy bulvar, Kemerovo, 650002

o_gruzdeva@mail.ruНаучно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийРоссияResearch Institute for Complex Issues of Cardiovascular DiseasesRussian Federation2023271220223812836Copyright © Белик Е.В., Дылева Ю.А., Груздева О.В., 20232023Белик Е.В., Дылева Ю.А., Груздева О.В.Belik E.V., Dyleva Y.A., Gruzdeva O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/1599

Несмотря на достигнутые успехи, ведущей причиной смертности во всем мире остаются сердечно-сосудистые заболевания (ССЗ). С помощью традиционных факторов риска не всегда возможно выявить всех пациентов с высокой вероятностью развития сердечно-сосудистых событий (CCC), поэтому до сих пор остается актуальной проблема поиска новых биомаркеров ССЗ. Ранее проведенные исследования показали важную роль избыточного синтеза церамидов в развитии ожирения, инсулинорезистентности (ИР), сахарного диабета 2-го типа (СД2), стеатоза печени. Считается, что церамиды способны модулировать сигнальные пути, участвующие в регуляции метаболизма глюкозы, синтеза триацилглицеролов (ТАГ), развитии апоптоза, фиброза и атеросклероза. Учитывая широкий спектр метаболических эффектов, изучение церамидов является перспективным для выявления пациентов высокого риска ССЗ и улучшения существующих лечебно-диагностических стратегий. В этой обзорной статье рассмотрена роль церамидов в развитии атеросклероза, взаимосвязь с традиционными факторами риска, а также возможность их использования в качестве новых факторов риска для ранней диагностики ССЗ.

Despite the successes achieved, cardiovascular disease (CVD) remains the leading cause of death worldwide. With the help of traditional risk factors, it is not always possible to identify all patients with a high probability of developing cardiovascular events (CVЕ); therefore, the problem of finding new CVD biomarkers still remains relevant. Previous studies have shown the important role of excessive synthesis of ceramides in the development of obesity, insulin resistance (IR), type 2 diabetes mellitus (DM2), and liver steatosis. It is considered that ceramides are able to modulate signaling pathways involved in the regulation of glucose metabolism, triglyceride synthesis, development of apoptosis, fibrosis, and atherosclerosis. Given the wide range of metabolic effects, the study of ceramides is promising for identifying patients at high risk of CVD, as well as improving existing treatment and diagnostic strategies. This review article considers the role of ceramides in the development of atherosclerosis, the correlation with traditional risk factors, and the possibility of using them as new risk factors for early diagnosis of CVD.

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The authors declare that there are no conflicts of interest present.