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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский журнал клинической и экспериментальной медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian Journal of Clinical and Experimental Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2713-2927</issn><issn pub-type="epub">2713-265X</issn><publisher><publisher-name>TSU publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29001/2073-8552-2023-38-2-98-103</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiotomsk-1793</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Особенности ведения пожилых пациентов с инфарктом миокарда без подъема сегмента ST: анализ факторов риска, диагностика и тактика лечения</article-title><trans-title-group xml:lang="en"><trans-title>Features of the management of elderly patients with non ST segment elevation myocardial infarction: analysis of risk factors, diagnosis and treatment strategy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3235-3364</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайнобидинов</surname><given-names>Ш. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaynobidinov</surname><given-names>Sh. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зайнобидинов Шохбозбек Шаробидин угли - врач по рентгенэндоваскулярным диагностике и лечению</p><p>630055, Российская Федерация, Новосибирск, ул. Речкуновская, 15 </p></bio><bio xml:lang="en"><p>Shokhbozbek Sh. Zaynobidinov - Surgeon, Department of Interventional Radiology Diagnostics and Treatment</p><p>15, Rechkunovskaya str., Novosibirsk, 630055, Russian Federation </p></bio><email xlink:type="simple">Shox.4454303@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5419-913X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хелимский</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khelimskii</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хелимский Дмитрий Александрович - канд. мед. наук, научный сотрудник, научно-исследовательский отдел эндоваскулярной хирургии, врач по рентгенэндоваскулярным диагностике и лечению  </p><p>630055, Российская Федерация, Новосибирск, ул. Речкуновская, 15 </p></bio><bio xml:lang="en"><p>Dmitrii A. Khelimskii - Cand. Sci. (Med.), Surgeon, Department of Interventional Radiology Diagnostics and Treatment </p><p>15, Rechkunovskaya str., Novosibirsk, 630055, Russian Federation </p></bio><email xlink:type="simple">dkhelim@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2320-2233</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баранов Алексей Алексеевич - аспирант</p><p>630055, Российская Федерация, Новосибирск, ул. Речкуновская, 15 </p></bio><bio xml:lang="en"><p> Alexey A. Baranov - Graduate Student </p><p>15, Rechkunovskaya str., Novosibirsk, 630055, Russian Federation </p></bio><email xlink:type="simple">ivrach@icloud.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1011-3397</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горгулько</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorgulko</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горгулько Александр Павлович, аспирант</p><p>630055, Российская Федерация, Новосибирск, ул. Речкуновская, 15 </p></bio><bio xml:lang="en"><p> Alexandr P. Gorgulko - Graduate Student </p><p>15, Rechkunovskaya str., Novosibirsk, 630055, Russian Federation </p></bio><email xlink:type="simple">alexandergorgulko@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7083-2297</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Манукян</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Manukian</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Манукян Сережа Нерсесович - аспирант</p><p>630055, Российская Федерация, Новосибирск, ул. Речкуновская, 15 </p></bio><bio xml:lang="en"><p> Serezha N. Manukian - Graduate Student</p><p>15, Rechkunovskaya str., Novosibirsk, 630055, Russian Federation </p></bio><email xlink:type="simple">sermanukyan88@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1384-7185</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Найденов</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Naydenov</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Найденов Роман Александрович - канд. мед. наук, заведующий отделением рентгенохирургических методов диагностики и лечения, врач по рентгенэндоваскулярным диагностике и лечению</p><p>630055, Российская Федерация, Новосибирск, ул. Речкуновская, 15 </p></bio><bio xml:lang="en"><p>Roman A. Naydenov - Cand. Sci. (Med.), Surgeon, Head of Department of Endovascular Diagnostics and Treatment </p><p>15, Rechkunovskaya str., Novosibirsk, 630055, Russian Federation </p></bio><email xlink:type="simple">r_naydenov@meshalkin.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5214-8996</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крестьянинов</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krestyaninov</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крестьянинов Олег Викторович - д-р мед. наук, заведующий научно-исследовательским отделом эндоваскулярной хирургии, врач по рентгенэндоваскулярным диагностике и лечению</p><p>630055, Российская Федерация, Новосибирск, ул. Речкуновская, 15 </p></bio><bio xml:lang="en"><p>Oleg V. Krestyaninov - Dr. Sci. (Med.), Head of Center for Endovascular Surgery, Head of Department of Endovascular Diagnostics and Treatment </p><p>15, Rechkunovskaya str., Novosibirsk, 630055, Russian Federation </p></bio><email xlink:type="simple">o_krestyaninov@meshalkin.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>E.Meshalkin National Medical Research Center of Ministry of Health of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>06</day><month>07</month><year>2023</year></pub-date><volume>38</volume><issue>2</issue><fpage>98</fpage><lpage>103</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зайнобидинов Ш.Ш., Хелимский Д.А., Баранов А.А., Горгулько А.П., Манукян С.Н., Найденов Р.А., Крестьянинов О.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Зайнобидинов Ш.Ш., Хелимский Д.А., Баранов А.А., Горгулько А.П., Манукян С.Н., Найденов Р.А., Крестьянинов О.В.</copyright-holder><copyright-holder xml:lang="en">Zaynobidinov S.S., Khelimskii D.A., Baranov A.A., Gorgulko A.P., Manukian S.N., Naydenov R.A., Krestyaninov O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sibjcem.ru/jour/article/view/1793">https://www.sibjcem.ru/jour/article/view/1793</self-uri><abstract><p>Несмотря на развитие современных технологий в сфере здравоохранения, летальность от сердечно-сосудистых заболеваний занимает лидирующее место в структуре общей смертности населения. Применение современных методов лечения, особенно чрескожного коронарного вмешательства (ЧКВ), позволяет оказывать своевременную помощь пациентам с острым коронарным синдромом (ОКС) и способствует снижению частоты летальных событий. В настоящее время разработаны четкие алгоритмы ведения пациентов с инфарктом миокарда с подъемом сегмента ST (ИМпST), однако, несмотря на это, существуют парадигмы при ведении пациентов с инфарктом миокарда без подъема сегмента ST (ИМбпST). В первую очередь это связано с тем, что подавляюще большинство пациентов с ИМбпST представлены лицами пожилого и старческого возраста. В настоящей обзорной статье авторы описали основные факторы, которые негативно влияют на краткосрочный и долгосрочный прогноз и продемонстрировали результаты клинических исследований, посвященных к изучению данной проблемы.</p></abstract><trans-abstract xml:lang="en"><p>Despite the technological developments in the healthcare industry, cardiovascular disease mortality occupies a leading place among the structure of general mortality of the population. The use of modern treatment methods, especially, percutaneous coronary intervention, provides timely assistance to patients with acute coronary syndrome and helps to reduce mortality frequency. Currently, clear algorithms for the management of patients with ST-segment elevation myocardial infarction have been developed. However, despite it, there are paradigms in the management of patients with non-ST-segment elevation myocardial infarction (NSTEMI). This is primarily due to the fact that the vast majority of patients with NSTEMI are elderly and senile persons. This review article presented the main factors that adversely affect short- and long-term prognosis and results of clinical studies dedicated to the study of this problem.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый коронарный синдром</kwd><kwd>инфаркт миокарда</kwd><kwd>инфаркт миокарда без подъема сегмента ST</kwd><kwd>чрескожное коронарное вмешательство</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute coronary syndrome</kwd><kwd>myocardial infarction</kwd><kwd>non ST segment elevation myocardial infarction</kwd><kwd>percutaneous coronary intervention</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Федеральная служба государственной статистики (Росстат) 2020 г. [Federal State Statistics Service (Rosstat) 2020. (In Russ.)]. URL: https://rosstat.gov.ru/folder/12781 (21.12.2022).</mixed-citation><mixed-citation xml:lang="en">Федеральная служба государственной статистики (Росстат) 2020 г. [Federal State Statistics Service (Rosstat) 2020. (In Russ.)]. URL: https://rosstat.gov.ru/folder/12781 (21.12.2022).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Basit H., Malik A., Huecker M.R. Non ST Segment Elevation Myocardial Infarction; 2022. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.</mixed-citation><mixed-citation xml:lang="en">Basit H., Malik A., Huecker M.R. Non ST Segment Elevation Myocardial Infarction; 2022. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Khera S., Kolte D., Aronow W.S., Palaniswamy C., Subramanian K.S., Hashim T. et al. Non-ST-elevation myocardial infarction in the United States: contemporary trends in incidence, utilization of the early invasive strategy, and in-hospital outcomes. J. Am. Heart Assoc. 2014;3(4):e000995. DOI: 10.1161/JAHA.114.000995.</mixed-citation><mixed-citation xml:lang="en">Khera S., Kolte D., Aronow W.S., Palaniswamy C., Subramanian K.S., Hashim T. et al. Non-ST-elevation myocardial infarction in the United States: contemporary trends in incidence, utilization of the early invasive strategy, and in-hospital outcomes. J. Am. Heart Assoc. 2014;3(4):e000995. DOI: 10.1161/JAHA.114.000995.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Yeh R.W., Sidney S., Chandra M., Sorel M., Selby J.V., Go A.S. Population trends in the incidence and outcomes of acute myocardial infarction. N. Engl. J. Med. 2010;362(23):2155–2165. DOI: 10.1056/NEJMoa0908610.</mixed-citation><mixed-citation xml:lang="en">Yeh R.W., Sidney S., Chandra M., Sorel M., Selby J.V., Go A.S. Population trends in the incidence and outcomes of acute myocardial infarction. N. Engl. J. Med. 2010;362(23):2155–2165. DOI: 10.1056/NEJMoa0908610.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Dyussenbayev A. Age periods of human life. Advances in Social Sciences Research Journal. 2017;4(6). DOI: 10.14738/assrj.46.2924. 6. Nichols M., Townsend N., Scarborough P., Rayner M. Cardiovascular disease in Europe 2014: epidemiological update. Eur. Heart J. 2014;35(42):2950–2959. DOI: 10.1093/eurheartj/ehu299.</mixed-citation><mixed-citation xml:lang="en">Dyussenbayev A. Age periods of human life. Advances in Social Sciences Research Journal. 2017;4(6). DOI: 10.14738/assrj.46.2924. 6. Nichols M., Townsend N., Scarborough P., Rayner M. Cardiovascular disease in Europe 2014: epidemiological update. Eur. Heart J. 2014;35(42):2950–2959. DOI: 10.1093/eurheartj/ehu299.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Rogers W.J., Canto J.G., Lambrew C.T., Tiefenbrunn A.J., Kinkaid B., Shoultz D.A. et al. Temporal trends in the treatment of over 1.5 million patients with myocardial infarction in the US from 1990 through 1999: the National Registry of Myocardial Infarction 1, 2 and 3. J. Am. Coll. Cardiol. 2000;36(7):2056–63. DOI: 10.1016/s0735-1097(00)00996-7.</mixed-citation><mixed-citation xml:lang="en">Rogers W.J., Canto J.G., Lambrew C.T., Tiefenbrunn A.J., Kinkaid B., Shoultz D.A. et al. Temporal trends in the treatment of over 1.5 million patients with myocardial infarction in the US from 1990 through 1999: the National Registry of Myocardial Infarction 1, 2 and 3. J. Am. Coll. Cardiol. 2000;36(7):2056–63. DOI: 10.1016/s0735-1097(00)00996-7.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Carro A., Kaski J.C. Myocardial infarction in the elderly. Aging Dis. 2011;2(2):116–137.</mixed-citation><mixed-citation xml:lang="en">Carro A., Kaski J.C. Myocardial infarction in the elderly. Aging Dis. 2011;2(2):116–137.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rashid M., Fischman D.L., Gulati M., Tamman K., Potts J., Kwok C.Sh. et al. Temporal trends and inequalities in coronary angiography utilization in the management of non-ST-Elevation acute coronary syndromes in the U.S. Sci. Rep. 2019;9:240. DOI: 10.1038/s41598-018-36504-y.</mixed-citation><mixed-citation xml:lang="en">Rashid M., Fischman D.L., Gulati M., Tamman K., Potts J., Kwok C.Sh. et al. Temporal trends and inequalities in coronary angiography utilization in the management of non-ST-Elevation acute coronary syndromes in the U.S. Sci. Rep. 2019;9:240. DOI: 10.1038/s41598-018-36504-y.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Morici N., Savonitto S., Ferri L.A., Grosseto D., Bossi I., Sganzerla P. et al. Elderly ACS-2 Investigators. Outcomes of Elderly Patients with ST-Elevation or Non-ST-Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention. Am. J. Med. 2019;132(2):209–216. DOI: 10.1016/j.amjmed.2018.10.027.</mixed-citation><mixed-citation xml:lang="en">Morici N., Savonitto S., Ferri L.A., Grosseto D., Bossi I., Sganzerla P. et al. Elderly ACS-2 Investigators. Outcomes of Elderly Patients with ST-Elevation or Non-ST-Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention. Am. J. Med. 2019;132(2):209–216. DOI: 10.1016/j.amjmed.2018.10.027.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kaura A., Sterne J.A.C., Trickey A., Abbott S., Mulla A., Glampson B. et al. Invasive versus non-invasive management of older patients with nonST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data. Lancet. 2020;396(10251):623–634. DOI: 10.1016/S0140-6736(20)30930-2.</mixed-citation><mixed-citation xml:lang="en">Kaura A., Sterne J.A.C., Trickey A., Abbott S., Mulla A., Glampson B. et al. Invasive versus non-invasive management of older patients with nonST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data. Lancet. 2020;396(10251):623–634. DOI: 10.1016/S0140-6736(20)30930-2.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Al Suwaidi J., Reddan D.N., Williams K., Pieper K.S., Harrington R.A., Califf R.M. et al. Prognostic implications of abnormalities in renal function in patients with acute coronary syndromes. Circulation. 2002;106(8):974–80. DOI: 10.1161/01.cir.0000027560.41358.b3.</mixed-citation><mixed-citation xml:lang="en">Al Suwaidi J., Reddan D.N., Williams K., Pieper K.S., Harrington R.A., Califf R.M. et al. Prognostic implications of abnormalities in renal function in patients with acute coronary syndromes. Circulation. 2002;106(8):974–80. DOI: 10.1161/01.cir.0000027560.41358.b3.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ekerstad N., Swahn E., Janzon M., Alfredsson J., Löfmark R., Lindenberger M. et al. Frailty is independently associated with short-term outcomes for elderly patients with non-ST-segment elevation myocardial infarction. Circulation. 2011;124(22):2397–2404. DOI: 10.1161/CIRCULATIONAHA.111.025452.</mixed-citation><mixed-citation xml:lang="en">Ekerstad N., Swahn E., Janzon M., Alfredsson J., Löfmark R., Lindenberger M. et al. Frailty is independently associated with short-term outcomes for elderly patients with non-ST-segment elevation myocardial infarction. Circulation. 2011;124(22):2397–2404. DOI: 10.1161/CIRCULATIONAHA.111.025452.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Afilalo J., Alexander K.P., Mack M.J., Maurer M.S., Green P., Allen L.A. et al. Frailty assessment in the cardiovascular care of older adults. J. Am. Coll. Cardiol. 2014;63(8):747–762. DOI: 10.1016/j.jacc.2013.09.070.</mixed-citation><mixed-citation xml:lang="en">Afilalo J., Alexander K.P., Mack M.J., Maurer M.S., Green P., Allen L.A. et al. Frailty assessment in the cardiovascular care of older adults. J. Am. Coll. Cardiol. 2014;63(8):747–762. DOI: 10.1016/j.jacc.2013.09.070.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Fried L.P., Tangen C.M., Walston J., Newman A.B., Hirsch C., Gottdiener J. et al. Frailty in older adults: evidence for a phenotype. J. Gerontol. A. Biol. Sci. Med. Sci. 2001;56(3):M146–56. DOI: 10.1093/gerona/56.3.m146.</mixed-citation><mixed-citation xml:lang="en">Fried L.P., Tangen C.M., Walston J., Newman A.B., Hirsch C., Gottdiener J. et al. Frailty in older adults: evidence for a phenotype. J. Gerontol. A. Biol. Sci. Med. Sci. 2001;56(3):M146–56. DOI: 10.1093/gerona/56.3.m146.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sanchis J., Bonanad C., Ruiz V., Fernández J., García-Blas S., Mainar L. et al. Frailty and other geriatric conditions for risk stratification of older patients with acute coronary syndrome. Am. Heart J. 2014;168(5):784–791. DOI: 10.1016/j.ahj.2014.07.022.</mixed-citation><mixed-citation xml:lang="en">Sanchis J., Bonanad C., Ruiz V., Fernández J., García-Blas S., Mainar L. et al. Frailty and other geriatric conditions for risk stratification of older patients with acute coronary syndrome. Am. Heart J. 2014;168(5):784–791. DOI: 10.1016/j.ahj.2014.07.022.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ekerstad N., Swahn E., Janzon M., Alfredsson J., Löfmark R., Lindenberger M. et al. Frailty is independently associated with 1-year mortality for elderly patients with non-ST-segment elevation myocardial infarction. Eur. J. Prev. Cardiol. 2014;21(10):1216–1224. DOI: 10.1177/2047487313490257.</mixed-citation><mixed-citation xml:lang="en">Ekerstad N., Swahn E., Janzon M., Alfredsson J., Löfmark R., Lindenberger M. et al. Frailty is independently associated with 1-year mortality for elderly patients with non-ST-segment elevation myocardial infarction. Eur. J. Prev. Cardiol. 2014;21(10):1216–1224. DOI: 10.1177/2047487313490257.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sanchis J., Soler M., Núñez J., Ruiz V., Bonanad C., Formiga F. et al. Comorbidity assessment for mortality risk stratification in elderly patients with acute coronary syndrome. Eur. J. Intern. Med. 2019;62:48–53. DOI: 10.1016/j.ejim.2019.01.018.</mixed-citation><mixed-citation xml:lang="en">Sanchis J., Soler M., Núñez J., Ruiz V., Bonanad C., Formiga F. et al. Comorbidity assessment for mortality risk stratification in elderly patients with acute coronary syndrome. Eur. J. Intern. Med. 2019;62:48–53. DOI: 10.1016/j.ejim.2019.01.018.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Sabatine M.S., Morrow D.A., Giugliano R.P., Burton P.B., Murphy S.A., McCabe C.H. et al. Association of hemoglobin levels with clinical outcomes in acute coronary syndromes. Circulation. 2005;111(16):2042–2049. DOI: 10.1161/01.CIR.0000162477.70955.5F.</mixed-citation><mixed-citation xml:lang="en">Sabatine M.S., Morrow D.A., Giugliano R.P., Burton P.B., Murphy S.A., McCabe C.H. et al. Association of hemoglobin levels with clinical outcomes in acute coronary syndromes. Circulation. 2005;111(16):2042–2049. DOI: 10.1161/01.CIR.0000162477.70955.5F.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Lawler P.R., Filion K.B., Dourian T., Atallah R., Garfinkle M., Eisenberg M.J. Anemia and mortality in acute coronary syndromes: a systematic review and meta-analysis. Am. Heart J. 2013;165(2):143–53.e5. DOI: 10.1016/j.ahj.2012.10.024.</mixed-citation><mixed-citation xml:lang="en">Lawler P.R., Filion K.B., Dourian T., Atallah R., Garfinkle M., Eisenberg M.J. Anemia and mortality in acute coronary syndromes: a systematic review and meta-analysis. Am. Heart J. 2013;165(2):143–53.e5. DOI: 10.1016/j.ahj.2012.10.024.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gaskell H., Derry S., Moore A.R., McQuay H.J. Prevalence of anaemia in older persons: systematic review. BMC Geriatr. 2008;8:1. DOI: 10.1186/1471-2318-8-1.</mixed-citation><mixed-citation xml:lang="en">Gaskell H., Derry S., Moore A.R., McQuay H.J. Prevalence of anaemia in older persons: systematic review. BMC Geriatr. 2008;8:1. DOI: 10.1186/1471-2318-8-1.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Dodson J.A., Hajduk A.M., Murphy T.E., Geda M., Krumholz H.M., Tsang S. et al. 180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study. Open Heart. 2021;8(1):e001442. DOI: 10.1136/openhrt-2020-001442.</mixed-citation><mixed-citation xml:lang="en">Dodson J.A., Hajduk A.M., Murphy T.E., Geda M., Krumholz H.M., Tsang S. et al. 180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study. Open Heart. 2021;8(1):e001442. DOI: 10.1136/openhrt-2020-001442.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Avezum A., Makdisse M., Spencer F., Gore J.M., Fox K.A., Montalescot G. et al. Impact of age on management and outcome of acute coronary syndrome: observations from the Global Registry of Acute Coronary Events (GRACE). Am. Heart J. 2005;149(1):67–73. DOI: 10.1016/j.ahj.2004.06.003.</mixed-citation><mixed-citation xml:lang="en">Avezum A., Makdisse M., Spencer F., Gore J.M., Fox K.A., Montalescot G. et al. Impact of age on management and outcome of acute coronary syndrome: observations from the Global Registry of Acute Coronary Events (GRACE). Am. Heart J. 2005;149(1):67–73. DOI: 10.1016/j.ahj.2004.06.003.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Roe M.T., Goodman S.G., Ohman E.M., Stevens S.R., Hochman J.S., Gottlieb S. et al. Elderly patients with acute coronary syndromes managed without revascularization: insights into the safety of long-term dual antiplatelet therapy with reduced-dose prasugrel versus standard-dose clopidogrel. Circulation. 2013;128(8):823–833. DOI: 10.1161/CIRCULATIONAHA.113.002303.</mixed-citation><mixed-citation xml:lang="en">Roe M.T., Goodman S.G., Ohman E.M., Stevens S.R., Hochman J.S., Gottlieb S. et al. Elderly patients with acute coronary syndromes managed without revascularization: insights into the safety of long-term dual antiplatelet therapy with reduced-dose prasugrel versus standard-dose clopidogrel. Circulation. 2013;128(8):823–833. DOI: 10.1161/CIRCULATIONAHA.113.002303.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mehran R., Pocock S., Nikolsky E., Dangas G.D., Clayton T., Claessen B.E. et al. Impact of bleeding on mortality after percutaneous coronary intervention results from a patient-level pooled analysis of the REPLACE-2 (randomized evaluation of PCI linking angiomax to reduced clinical events), ACUITY (acute catheterization and urgent intervention triage strategy), and HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trials. JACC Cardiovasc. Interv. 2011;4(6):654–64. DOI: 10.1016/j.jcin.2011.02.011.</mixed-citation><mixed-citation xml:lang="en">Mehran R., Pocock S., Nikolsky E., Dangas G.D., Clayton T., Claessen B.E. et al. Impact of bleeding on mortality after percutaneous coronary intervention results from a patient-level pooled analysis of the REPLACE-2 (randomized evaluation of PCI linking angiomax to reduced clinical events), ACUITY (acute catheterization and urgent intervention triage strategy), and HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trials. JACC Cardiovasc. Interv. 2011;4(6):654–64. DOI: 10.1016/j.jcin.2011.02.011.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Krijthe B.P., Kunst A., Benjamin E.J., Lip G.Y., Franco O.H., Hofman A. et al. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060. Eur. Heart J. 2013;34:2746–2751. DOI: 10.1093/eurheartj/eht280.</mixed-citation><mixed-citation xml:lang="en">Krijthe B.P., Kunst A., Benjamin E.J., Lip G.Y., Franco O.H., Hofman A. et al. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060. Eur. Heart J. 2013;34:2746–2751. DOI: 10.1093/eurheartj/eht280.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Di Carlo A., Bellino L., Consoli D., Mori F., Zaninelli A., Baldereschi M. et al. Prevalence of atrial fibrillation in the Italian elderly population and projections from 2020 to 2060 for Italy and the European Union: the FAI Project. Europace. 2019;21(10):1468–1475. DOI: 10.1093/europace/euz141.</mixed-citation><mixed-citation xml:lang="en">Di Carlo A., Bellino L., Consoli D., Mori F., Zaninelli A., Baldereschi M. et al. Prevalence of atrial fibrillation in the Italian elderly population and projections from 2020 to 2060 for Italy and the European Union: the FAI Project. Europace. 2019;21(10):1468–1475. DOI: 10.1093/europace/euz141.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kannel W.B., Wolf P.A., Castelli W.P., D’Agostino R.B. Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA. 1987;258(9):1183–6.</mixed-citation><mixed-citation xml:lang="en">Kannel W.B., Wolf P.A., Castelli W.P., D’Agostino R.B. Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA. 1987;258(9):1183–6.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Balleisen L., Bailey J., Epping P.H., Schulte H., van de Loo J. Epidemiological study on factor VII, factor VIII and fibrinogen in an industrial population: I. Baseline data on the relation to age, gender, body-weight, smoking, alcohol, pill-using, and menopause. Thromb. Haemost. 1985;54(2):475–479.</mixed-citation><mixed-citation xml:lang="en">Balleisen L., Bailey J., Epping P.H., Schulte H., van de Loo J. Epidemiological study on factor VII, factor VIII and fibrinogen in an industrial population: I. Baseline data on the relation to age, gender, body-weight, smoking, alcohol, pill-using, and menopause. Thromb. Haemost. 1985;54(2):475–479.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Conlan M.G., Folsom A.R., Finch A., Davis C.E., Sorlie P., Marcucci G. et al. Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Thromb. Haemost. 1993;70(3):380–385.</mixed-citation><mixed-citation xml:lang="en">Conlan M.G., Folsom A.R., Finch A., Davis C.E., Sorlie P., Marcucci G. et al. Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Thromb. Haemost. 1993;70(3):380–385.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Quinn T.J., Alghamdi J., Padmanabhan S., Porteous D.J., Smith B.H., Hocking L. et al. Association between cognition and gene polymorphisms involved in thrombosis and haemostasis. Age (Dordr). 2015;37(4):9820. DOI: 10.1007/s11357-015-9820-y.</mixed-citation><mixed-citation xml:lang="en">Quinn T.J., Alghamdi J., Padmanabhan S., Porteous D.J., Smith B.H., Hocking L. et al. Association between cognition and gene polymorphisms involved in thrombosis and haemostasis. Age (Dordr). 2015;37(4):9820. DOI: 10.1007/s11357-015-9820-y.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Berge T., Ulimoen S.R., Enger S., Arnesen H., Seljeflot I., Tveit A. Impact of atrial fibrillation on inflammatory and fibrinolytic variables in the elderly. Scand. J. Clin. Lab. Invest. 2013;73(4):326–33. DOI: 10.3109/00365513.2013.780093.</mixed-citation><mixed-citation xml:lang="en">Berge T., Ulimoen S.R., Enger S., Arnesen H., Seljeflot I., Tveit A. Impact of atrial fibrillation on inflammatory and fibrinolytic variables in the elderly. Scand. J. Clin. Lab. Invest. 2013;73(4):326–33. DOI: 10.3109/00365513.2013.780093.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">James S.K., Armstrong P., Barnathan E., Califf R., Lindahl B., Siegbahn A. et al. Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome: a GUSTO-IV substudy. J. Am. Coll. Cardiol. 2003;41(6):916–924. DOI: 10.1016/s0735-1097(02)02969-8.</mixed-citation><mixed-citation xml:lang="en">James S.K., Armstrong P., Barnathan E., Califf R., Lindahl B., Siegbahn A. et al. Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome: a GUSTO-IV substudy. J. Am. Coll. Cardiol. 2003;41(6):916–924. DOI: 10.1016/s0735-1097(02)02969-8.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ndrepepa G., Neumann F.J., Schulz S., Fusaro M., Cassese S., Byrne R.A. et al. Incidence and prognostic value of bleeding after percutaneous coronary intervention in patients older than 75 years of age. Catheter Cardiovasc. Interv. 2014;83(2):182–189. DOI: 10.1002/ccd.25189.</mixed-citation><mixed-citation xml:lang="en">Ndrepepa G., Neumann F.J., Schulz S., Fusaro M., Cassese S., Byrne R.A. et al. Incidence and prognostic value of bleeding after percutaneous coronary intervention in patients older than 75 years of age. Catheter Cardiovasc. Interv. 2014;83(2):182–189. DOI: 10.1002/ccd.25189.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Hirlekar G., Libungan B., Karlsson T., Bäck M., Herlitz J., Albertsson P. Percutaneous coronary intervention in the very elderly with NSTE-ACS: the randomized 80+ study. Scand. Cardiovasc. J. 2020;54(5):315–321. DOI: 10.1080/14017431.2020.1781243.</mixed-citation><mixed-citation xml:lang="en">Hirlekar G., Libungan B., Karlsson T., Bäck M., Herlitz J., Albertsson P. Percutaneous coronary intervention in the very elderly with NSTE-ACS: the randomized 80+ study. Scand. Cardiovasc. J. 2020;54(5):315–321. DOI: 10.1080/14017431.2020.1781243.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Valgimigli M., Frigoli E., Heg D., Tijssen J., Jüni P., Vranckx P. et al. Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk. N. Engl. J. Med. 2021;385(18):1643–1655. DOI: 10.1056/NEJMoa2108749.</mixed-citation><mixed-citation xml:lang="en">Valgimigli M., Frigoli E., Heg D., Tijssen J., Jüni P., Vranckx P. et al. Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk. N. Engl. J. Med. 2021;385(18):1643–1655. DOI: 10.1056/NEJMoa2108749.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Cockburn J., Hildick-Smith D., Trivedi U., de Belder A. Coronary revascularisation in the elderly. Heart. 2017;103(4):316–324. DOI: 10.1136/heartjnl-2015-308999.</mixed-citation><mixed-citation xml:lang="en">Cockburn J., Hildick-Smith D., Trivedi U., de Belder A. Coronary revascularisation in the elderly. Heart. 2017;103(4):316–324. DOI: 10.1136/heartjnl-2015-308999.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmed O.E., Abohamr S.I., Alharbi S.A., Aldrewesh D.A., Allihimy A.S., Alkuraydis S.A. et al. In-hospital mortality of acute coronary syndrome in elderly patients. Saudi Med. J. 2019;40(10):1003–1007. DOI: 10.15537/smj.2019.10.24583.</mixed-citation><mixed-citation xml:lang="en">Ahmed O.E., Abohamr S.I., Alharbi S.A., Aldrewesh D.A., Allihimy A.S., Alkuraydis S.A. et al. In-hospital mortality of acute coronary syndrome in elderly patients. Saudi Med. J. 2019;40(10):1003–1007. DOI: 10.15537/smj.2019.10.24583.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Fox K.A., Dabbous O.H., Goldberg R.J., Pieper K.S., Eagle K.A., Van de Werf F. et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). BMJ. 2006;333(7578):1091. DOI: 10.1136/bmj.38985.646481.55.</mixed-citation><mixed-citation xml:lang="en">Fox K.A., Dabbous O.H., Goldberg R.J., Pieper K.S., Eagle K.A., Van de Werf F. et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). BMJ. 2006;333(7578):1091. DOI: 10.1136/bmj.38985.646481.55.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Alexander K.P., Roe M.T., Chen A.Y., Lytle B.L., Pollack C.V.Jr., Foody J.M. et al. Evolution in cardiovascular care for elderly patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative. J. Am. Coll. Cardiol. 2005;46(8):1479–1487. DOI: 10.1016/j.jacc.2005.05.084.</mixed-citation><mixed-citation xml:lang="en">Alexander K.P., Roe M.T., Chen A.Y., Lytle B.L., Pollack C.V.Jr., Foody J.M. et al. Evolution in cardiovascular care for elderly patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative. J. Am. Coll. Cardiol. 2005;46(8):1479–1487. DOI: 10.1016/j.jacc.2005.05.084.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Rajani R., Lindblom M., Dixon G., Khawaja M.Z., Hildick-Smith D., Holmberg S. et al. Evolving trends in percutaneous coronary intervention. Br. J. Cardiol. 2011;18:73–76.</mixed-citation><mixed-citation xml:lang="en">Rajani R., Lindblom M., Dixon G., Khawaja M.Z., Hildick-Smith D., Holmberg S. et al. Evolving trends in percutaneous coronary intervention. Br. J. Cardiol. 2011;18:73–76.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Rathod K.S., Koganti S., Jain A.K., Astroulakis Z., Lim P., Rakhit R. et al. Complete Versus Culprit-Only Lesion Intervention in Patients With Acute Coronary Syndromes. J. Am. Coll. Cardiol. 2018;72(17):1989–1999. DOI: 10.1016/j.jacc.2018.07.089.</mixed-citation><mixed-citation xml:lang="en">Rathod K.S., Koganti S., Jain A.K., Astroulakis Z., Lim P., Rakhit R. et al. Complete Versus Culprit-Only Lesion Intervention in Patients With Acute Coronary Syndromes. J. Am. Coll. Cardiol. 2018;72(17):1989–1999. DOI: 10.1016/j.jacc.2018.07.089.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kvakkestad K.M., Gran J.M., Eritsland J., Holst Hansen C., Fossum E., Andersen G.Ø. et al. Long-Term Survival after Invasive or Conservative Strategy in Elderly Patients with non-ST-Elevation Myocardial Infarction: A Prospective Cohort Study. Cardiology. 2019;144(3–4):79–89. DOI: 10.1159/000503442.</mixed-citation><mixed-citation xml:lang="en">Kvakkestad K.M., Gran J.M., Eritsland J., Holst Hansen C., Fossum E., Andersen G.Ø. et al. Long-Term Survival after Invasive or Conservative Strategy in Elderly Patients with non-ST-Elevation Myocardial Infarction: A Prospective Cohort Study. Cardiology. 2019;144(3–4):79–89. DOI: 10.1159/000503442.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Badimon L., Bugiardini R., Cubedo J. Pathophysiology of acute coronary syndromes in the elderly. Int. J. Cardiol. 2016;222:1105–1109. DOI: 10.1016/j.ijcard.2016.07.205.</mixed-citation><mixed-citation xml:lang="en">Badimon L., Bugiardini R., Cubedo J. Pathophysiology of acute coronary syndromes in the elderly. Int. J. Cardiol. 2016;222:1105–1109. DOI: 10.1016/j.ijcard.2016.07.205.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Guedeney P., Claessen B.E., Mehran R., Mintz G.S., Liu M., Sorrentino S. et al. Coronary Calcification and Long-Term Outcomes According to Drug-Eluting Stent Generation. JACC Cardiovasc Interv. 2020;13(12):1417–1428. DOI: 10.1016/j.jcin.2020.03.053.</mixed-citation><mixed-citation xml:lang="en">Guedeney P., Claessen B.E., Mehran R., Mintz G.S., Liu M., Sorrentino S. et al. Coronary Calcification and Long-Term Outcomes According to Drug-Eluting Stent Generation. JACC Cardiovasc Interv. 2020;13(12):1417–1428. DOI: 10.1016/j.jcin.2020.03.053.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Schenker M.P., Dorbala S., Hong E.C., Rybicki F.J., Hachamovitch R., Kwong R.Y. et al. Interrelation of coronary calcification, myocardial ischemia, and outcomes in patients with intermediate likelihood of coronary artery disease: a combined positron emission tomography/computed tomography study. Circulation. 2008;117(13):1693–1700. DOI: 10.1161/CIRCULATIONAHA.107.717512.</mixed-citation><mixed-citation xml:lang="en">Schenker M.P., Dorbala S., Hong E.C., Rybicki F.J., Hachamovitch R., Kwong R.Y. et al. Interrelation of coronary calcification, myocardial ischemia, and outcomes in patients with intermediate likelihood of coronary artery disease: a combined positron emission tomography/computed tomography study. Circulation. 2008;117(13):1693–1700. DOI: 10.1161/CIRCULATIONAHA.107.717512.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar S., McDaniel M., Samady H., Forouzandeh F. Contemporary Revascularization Dilemmas in Older Adults. J. Am. Heart Assoc. 2020;9(3):e014477. DOI: 10.1161/JAHA.119.014477.</mixed-citation><mixed-citation xml:lang="en">Kumar S., McDaniel M., Samady H., Forouzandeh F. Contemporary Revascularization Dilemmas in Older Adults. J. Am. Heart Assoc. 2020;9(3):e014477. DOI: 10.1161/JAHA.119.014477.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Savonitto S., Cavallini C., Petronio A.S., Murena E., Antonicelli R., Sacco A. et al. Italian Elderly ACS Trial Investigators. Early aggressive versus initially conservative treatment in elderly patients with non-ST-segment elevation acute coronary syndrome: a randomized controlled trial. JACC Cardiovasc. Interv. 2012;5(9):906–916. DOI: 10.1016/j.jcin.2012.06.008.</mixed-citation><mixed-citation xml:lang="en">Savonitto S., Cavallini C., Petronio A.S., Murena E., Antonicelli R., Sacco A. et al. Italian Elderly ACS Trial Investigators. Early aggressive versus initially conservative treatment in elderly patients with non-ST-segment elevation acute coronary syndrome: a randomized controlled trial. JACC Cardiovasc. Interv. 2012;5(9):906–916. DOI: 10.1016/j.jcin.2012.06.008.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Tegn N., Abdelnoor M., Aaberge L., Endresen K., Smith P., Aakhus S. et al. After Eighty study investigators. Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): an open-label randomised controlled trial. Lancet. 2016;387(10023):1057–1065. DOI: 10.1016/S0140-6736(15)01166-6.</mixed-citation><mixed-citation xml:lang="en">Tegn N., Abdelnoor M., Aaberge L., Endresen K., Smith P., Aakhus S. et al. After Eighty study investigators. Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): an open-label randomised controlled trial. Lancet. 2016;387(10023):1057–1065. DOI: 10.1016/S0140-6736(15)01166-6.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Garg A., Garg L., Agarwal M., Rout A., Raheja H., Agrawal S. et al. Routine Invasive Versus Selective Invasive Strategy in Elderly Patients Older Than 75 Years With Non-ST-Segment Elevation Acute Coronary Syndrome: A Systematic Review and Meta-Analysis. Mayo. Clin. Proc. 2018;93(4):436–444. DOI: 10.1016/j.mayocp.2017.11.022.</mixed-citation><mixed-citation xml:lang="en">Garg A., Garg L., Agarwal M., Rout A., Raheja H., Agrawal S. et al. Routine Invasive Versus Selective Invasive Strategy in Elderly Patients Older Than 75 Years With Non-ST-Segment Elevation Acute Coronary Syndrome: A Systematic Review and Meta-Analysis. Mayo. Clin. Proc. 2018;93(4):436–444. DOI: 10.1016/j.mayocp.2017.11.022.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
