cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2022-585cardiotomsk-1853Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESδ-Опиоидный рецептор – мишень для создания пептидных препаратов, повышающих резистентность сердца к реперфузииδ-Opioid receptor as a target for the creation of peptide drugs that increase cardiac resistance to reperfusionhttps://orcid.org/0000-0003-1808-556XМухомедзяновА. В.MukhomedzyanovA. V.

Мухомедзянов Александр Валерьевич, канд. мед. наук, научный сотрудник, лаборатория экспериментальной кардиологии

634012, Томск, ул. Киевская, 111а

Alexander V. Mukhomedzyanov, Cand. Sci. (Med.), Research Scientist, Laboratory of Experimental Cardiology

111a, Kievskaya str., Tomsk, 634012

sasha_m91@mail.ruhttps://orcid.org/0000-0002-1607-1482ПоповС. В.PopovS. V.

Попов Сергей Валентинович, д-р мед. наук, профессор, академик РАН, директор 

634012, Томск, ул. Киевская, 111а

Sergey V. Popov, Dr. Sci. (Med.), Professor, Director, Cardiology Research Institute,

Tomsk National Research Medical Center, Russian Academy of Sciences, Academician of the Russian Academy of Sciences

111a, Kievskaya str., Tomsk, 634012

press@cardio-tomsk.ruhttps://orcid.org/0000-0003-2264-1928НарыжнаяН. В.NaryzhnayaN. V.

Нарыжная Наталья Владимировна, д-р мед. наук, ведущий научный сотрудник, лаборатория экспериментальной кардиологии

634012, Томск, ул. Киевская, 111а

Natalia V. Naryzhnaya, Dr. Sci. (Med.), Leading Research Scientist, Laboratory of Experimental Cardiology

111a, Kievskaya str., Tomsk, 634012

natalynar@yandex.ruhttps://orcid.org/0000-0002-4502-0836СиротинаМ. А.SirotinaM. А.

Сиротина Мария Александровна, младший научный сотрудник, лаборатория экспериментальной кардиологии

634012, Томск, ул. Киевская, 111а

Maria А. Sirotina, Junior Research Scientist, Laboratory of Experimental Cardiology

111a, Kievskaya str., Tomsk, 634012

sirotina_maria@mail.ruhttps://orcid.org/0000-0002-6020-1598МасловЛ. Н.MaslovL. N.

Маслов Леонид Николаевич, д-р мед. наук, профессор, заведующий лабораторией экспериментальной кардиологии

634012, Томск, ул. Киевская, 111а

Leonid N. Maslov, Dr. Sci. (Med.), Professor, Head of the Laboratory of Experimental Cardiology

111a, Kievskaya str., Tomsk, 634012

Maslov@cardio-tomsk.ruhttps://orcid.org/0000-0001-9603-822XКурбатовБ. К.KurbatovB. K.

Курбатов Борис Константинович, младший научный сотрудник, лаборатория экспериментальной кардиологии

634012, Томск, ул. Киевская, 111а

Boris K. Kurbatov, Junior Research Scientist, Laboratory of Experimental Cardiology

111a, Kievskaya str., Tomsk, 634012

bobersanker@gmail.comhttps://orcid.org/0000-0002-5890-071XГорбуновА. С.GorbunovA. S.

Горбунов Александр Сергеевич, канд. мед. наук, старший научный сотрудник, лаборатория экспериментальной кардиологии

634012, Томск, ул. Киевская, 111а

Alexander S. Gorbunov, Cand. Sci. (Med.), Senior Research Scientist, Laboratory of Experimental Cardiology

111a, Kievskaya str., Tomsk, 634012

shura.gorbunov.1982@mail.ruhttps://orcid.org/0000-0002-4300-5763КилинМ.KilinM.

Килин Михаил, лаборант, лаборатория экспериментальной кардиологии

634012, Томск, ул. Киевская, 111а

Mikhail Kilin, Laboratory Assistant, Laboratory of Experimental Cardiology

111a, Kievskaya str., Tomsk, 634012

Kilin112233@gmail.comhttps://orcid.org/0000-0002-6418-1643КанА.KanA.

Кан Артур, студент

634050, Томск, Московский тракт, 2

Artur Kan, Medical Student

2, Moskovsky trakt, Tomsk, 634050

kan989817@gmail.comhttps://orcid.org/0000-0003-4341-3844КрылатовА. В.KrylatovA. V.

Крылатов Андрей Владимирович, канд. мед. наук, лаборант-исследователь, лаборатория экспериментальной кардиологии

634012, Томск, ул. Киевская, 111а

Andrey V. Krylatov, Cand. Sci. (Med.), Research Assistant, Laboratory of Experimental Cardiology

111a, Kievskaya str., Tomsk, 634012

krylatovav@mail.ruhttps://orcid.org/0000-0002-8939-2340ПодоксёновЮ. К.PodoksenovYu. K.

Подоксёнов Юрий Кириллович, д-р мед. наук, ведущий научный сотрудник, отделение анестезиологии-реанимации

634012, Томск, ул. Киевская, 111а

Yuri K. Podoksenov, Dr. Sci. (Med.), Leading Research Scientist, Department of Anesthesiology and Resuscitation

111a, Kievskaya str., Tomsk, 634012

uk@cardio-tomsk.ruhttps://orcid.org/0000-0003-3275-4811АзевВ. Н.AzevV. N.

Азев Вячеслав Николаевич, канд. хим. наук, старший научный сотрудник, руководитель группы химии пептидов, отдел биотехнологии

142290, Московская область, Пущино, просп. Науки, 6

Viacheslav N. Azev, Cand. Sci. (Chem.), Senior Research Scientist, Biotechnology Department

6, Prospect of Science, Pushchino, 142290, Moscow Region

viatcheslav.azev@bibch.ruhttps://orcid.org/0000-0003-3274-6010ЛасуковаТ. В.LasukovaT. V.

Ласукова Татьяна Викторовна, д-р биол. наук, профессор, кафедра нормальной физиологии

634050, Томск, Московский тракт, 2

Tatyana V. Lasukova, Dr. Sci (Biol.), Professor, Department of Normal Physiology

2, Moskovsky trakt, Tomsk, 634050

tlasukova@mail.ruhttps://orcid.org/0000-0003-1291-0661СуфиановаГ. З.SufianovaG. Z.

Суфианова Галина Зиновьевна, д-р мед. наук, профессор, заведующий кафедрой фармакологии

625023, Тюмень, ул. Одесская, 4

Galina Z. Sufianova, Dr. Sci. (Med.), Professor, Head of the Department of Pharmacology

4, Odesskaya str., Tyumen, 625023

sufarm@mail.ruhttps://orcid.org/0000-0002-5966-8916ХлёсткинаМ. С.KhlestkinaM. S.

Хлёсткина Мария Сергеевна, ассистент кафедры фармакологии

625023, Тюмень, ул. Одесская, 4

Maria S. Khlestkina, Assistant Professor, Department of Pharmacology

4, Odesskaya str., Tyumen, 625023

kh_m_s@mail.ruНаучно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наукРоссияCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesRussian FederationСибирский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияSiberian State Medical University of the Ministry of Health of the Russian FederationRussian FederationФилиал Федерального государственного бюджетного учреждения науки «Институт биоорганической химии имени академиков М.М. Шемякина и Ю.А. Овчинникова» Российской академии наукРоссияBranch of the Shemyakin – Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesRussian FederationТюменский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияTyumen State Medical UniversityRussian Federation2024140820233911117Copyright © Мухомедзянов А.В., Попов С.В., Нарыжная Н.В., Сиротина М.А., Маслов Л.Н., Курбатов Б.К., Горбунов А.С., Килин М., Кан А., Крылатов А.В., Подоксёнов Ю.К., Азев В.Н., Ласукова Т.В., Суфианова Г.З., Хлёсткина М.С., 20242024Мухомедзянов А.В., Попов С.В., Нарыжная Н.В., Сиротина М.А., Маслов Л.Н., Курбатов Б.К., Горбунов А.С., Килин М., Кан А., Крылатов А.В., Подоксёнов Ю.К., Азев В.Н., Ласукова Т.В., Суфианова Г.З., Хлёсткина М.С.Mukhomedzyanov A.V., Popov S.V., Naryzhnaya N.V., Sirotina M.А., Maslov L.N., Kurbatov B.K., Gorbunov A.S., Kilin M., Kan A., Krylatov A.V., Podoksenov Y.K., Azev V.N., Lasukova T.V., Sufianova G.Z., Khlestkina M.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/1853

Анализ опубликованных данных и результатов собственных исследований показал, что активация периферических δ2-опиоидных рецепторов (δ2-ОР) повышает толерантность сердца к реперфузии. Установлено, что δ2-ОР находятся в кардиомиоцитах. Эндогенные опиоиды не участвуют в регуляции устойчивости сердца к реперфузии у неадаптированных крыс. Инфаркт-лимитирующий эффект агониста δ2-ОР дельторфина II зависит от активации протеинкиназ – ПКСδ, ERK1/2, PI3K, ПКG. Гипотетическими конечными эффекторами кардиопротекторного действия дельторфина II являются саркКАТФ-каналы и MPT-поры.

An analysis of published data and the results of our own studies showed that activation of peripheral δ2-opioid receptor (δ2-OR) increases cardiac tolerance to reperfusion. It has been established that this δ2-OR is localized in cardiomyocytes. Endogenous opioids are not involved in the regulation of cardiac resistance to reperfusion in non-adapted rats. The infarct-limiting effect of δ2-OR agonist deltorphin II depends on the activation of following protein kinases: PKCδ, ERK1/2, PI3K, PCG. SarcKATP channel and MPT pore are hypothetical end effectors of the cardioprotective effect of deltorphin II.

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The authors declare that there are no conflicts of interest present.