cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2023-581cardiotomsk-1980Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРоль терапевтической гипотермии в снижении реперфузионного повреждения у пациентов со STEMI: нарративный обзорThe role of therapeutic hypothermia in reducing of the reperfusion injury in patients with STEMI: narrative reviewhttps://orcid.org/0000-0003-2939-6291БогдановЮ. И.BogdanovYu. I.

Богданов Юрий Игоревич, канд. мед. наук, научный сотрудник, лаборатория рентгеэндоваскулярной хирургии

634012, г. Томск, ул. Киевская, 111 а

Yury I. Bogdanov, Cand. Sci. (Med.), Research Scientist, Laboratory of Endovascular Surgery

111a, Kievskaya str., Tomsk, 634012

yuri-bogdanov@mail.ruhttps://orcid.org/0000-0002-8163-1618БаевА. Е.BaevA. E.

Баев Андрей Евгеньевич, канд. мед. наук, заведующий лабораторией рентгенэндоваскулярной хирургии

634012, г. Томск, ул. Киевская, 111 а

Andrey E. Baev, Cand. Sci. (Med.), Head of the Laboratory of Endovascular Surgery

111a, Kievskaya str., Tomsk, 634012

stent111@mail.ruhttps://orcid.org/0000-0002-4358-7329РябовВ. В.RyabovV. V.

Рябов Вячеслав Валерьевич, д-р мед. наук, доцент, заместитель директора по научной и лечебной работе

634012, г. Томск, ул. Киевская, 111 а

Vyacheslav V. Ryabov, Dr. Sci. (Med.), Associate Professor, Deputy Director for Scientific and Medical Work

111a, Kievskaya str., Tomsk, 634012

rvvt@cardio-tomsk.ruhttps://orcid.org/0000-0002-4008-4021ПекарскийС. Е.PekarskyS. E.

Пекарский Станислав Евгеньевич, д-р мед. наук, ведущий научный сотрудник, лаборатория рентгенэндоваскулярной хирургии

634012, г. Томск, ул. Киевская, 111 а

Stanislav E. Pekarsky, Dr. Sci. (Med.), Senior Research Scientist, Laboratory of Endovascular Surgery

111a, Kievskaya str., Tomsk, 634012

pekarski@cardio-tomsk.ruГергертЕ. С.GergertE. S.

Гергерт Егор Сергеевич, младший научный сотрудник, лаборатория рентгенэндоваскулярной хирургии

634012, г. Томск, ул. Киевская, 111 а

Egor S. Gergert, Junior Research Scientist, Laboratory of Endovascular Surgery

111a, Kievskaya str., Tomsk, 634012

gergert-egor88@mail.ruhttps://orcid.org/0000-0001-9004-4768ГромовойР. М.GromovoyR. M.

Громовой Роман Михайлович, младший научный сотрудник, лаборатория рентгенэндоваскулярной хирургии

634012, г. Томск, ул. Киевская, 111 а

Roman M. Gromovoy, Junior Research Scientist, Laboratory of Endovascular Surgery

111a, Kievskaya str., Tomsk, 634012

roman.gromovoy@mail.ruhttps://orcid.org/0000-0001-5263-9488ТарасовМ. Г.TarasovM. G.

Тарасов Михаил Георгиевич, канд. мед. наук, младший научный сотрудник, лаборатория рентгенэндоваскулярной хирургии

634012, г. Томск, ул. Киевская, 111 а

Mikhail G. Tarasov, Cand. Sci. (Med.), Junior Research Scientist, Laboratory of Endovascular Surgery

111a, Kievskaya str., Tomsk, 634012

m3107@rambler.ruhttps://orcid.org/0000-0002-1569-2914СултановС. М.SultanovS. M.

Султанов Сыргак Мавланович, младший научный сотрудник, лаборатория рентгенэндоваскулярной хирургии

634012, г. Томск, ул. Киевская, 111 а

Syrgak M Sultanov, Junior Research Scientist, Laboratory of Endovascular Surgery

111a, Kievskaya str., Tomsk, 634012

omokb_onik@mail.ruhttps://orcid.org/0000-0002-0288-4191СусловИ. В.SuslovI. V.

Суслов Иван Владимирович, аспирант, лаборатория рентгенэндоваскулярной хирургии

634012, г. Томск, ул. Киевская, 111 а

Ivan V. Suslov, Junior Research Scientist, Laboratory of Endovascular Surgery

111a, Kievskaya str., Tomsk, 634012

straiker.acer@gmail.comНаучно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наук (НИИ кардиологии Томского НИМЦ)РоссияCardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences (Cardiology Research Institute, Tomsk NRMC)Russian Federation2024271020233931925Copyright © Богданов Ю.И., Баев А.Е., Рябов В.В., Пекарский С.Е., Гергерт Е.С., Громовой Р.М., Тарасов М.Г., Султанов С.М., Суслов И.В., 20242024Богданов Ю.И., Баев А.Е., Рябов В.В., Пекарский С.Е., Гергерт Е.С., Громовой Р.М., Тарасов М.Г., Султанов С.М., Суслов И.В.Bogdanov Y.I., Baev A.E., Ryabov V.V., Pekarsky S.E., Gergert E.S., Gromovoy R.M., Tarasov M.G., Sultanov S.M., Suslov I.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/1980

Несмотря на своевременную реперфузию, 7–10% пациентов с инфарктом миокарда умирают во время госпитализации, и у 23% выживших развивается сердечная недостаточность в течение одного года. Реперфузионное повреждение в большой степени ответственно за финальный размер инфаркта. Несмотря на прогресс в реваскуляризации миокарда, профилактика и лечение реперфузионного повреждения при инфаркте миокарда не является успешной в клинической практике. Гипотермия может уменьшить реперфузионное повреждение, тем самым улучшить выживаемость и снизить количество осложнений при остром инфаркте миокарда.

Despite timely coronary reperfusion, about 7% of patients with acute myocardial infarction die during hospitalization and around 23% survivors develop heart failure within one year. Reperfusion injury is largely responsible for the final infarct size. Although, there is some progress in myocardial revascularization, prevention and treatment of the reperfusion injury in myocardial infarction patients is not successful enough in clinical practice. Hypothermia can reduce reperfusion injury and improve survival and reduce the number of complications in patients with myocardial infarction.

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The authors declare that there are no conflicts of interest present.