cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2024-39-1-28-37cardiotomsk-2181Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESВнутрибольничные инфекции: взгляд на проблему в условиях глобальной угрозы антибиотикорезистентности (обзор)Nosocomial infections: a look at the problem in the context of the global threat of antibiotic resistance (review)https://orcid.org/0000-0002-1168-7405ПерфильеваД. Ю.PerfilevaD. Yu.

Перфильева Дарья Юрьевна, ассистент, кафедра организации здравоохранения и общественного здоровья

634050, Томск, Московский тракт, 2

Daria Yu. Perfileva, Assistant, Department Healthcare and Public Health Management

2, Moskovskiy tract str., Tomsk, 634050

perfileva.dy@ssmu.ruhttps://orcid.org/0000-0003-4035-8341МирошниченкоА. Г.MiroshnichenkoA. G.

Мирошниченко Александр Геннадьевич, д-р мед. наук, доцент, профессор, кафедра фармакологии

454092, Челябинск, ул. Воровского, 64

Alexander G. Miroshnichenko, Dr. Sci. (Med.), Associate Professor, Professor, Department of Pharmacology

64, Vorovskogo str., Chelyabinsk, 454092

ag.miro@yandex.ruhttps://orcid.org/0000-0002-0088-9204КуликовЕ. С.KulikovE. S.

Куликов Евгений Сергеевич, д-р мед. наук, доцент, профессор, кафедра общей врачебной практики и поликлинической терапии

634050, Томск, Московский тракт, 2

Evgeny S. Kulikov, Dr. Sci. (Med.), Associate Professor, Professor, Department of General Medical Practice and Polyclinic Therapy

2, Moskovskiy tract str., Tomsk, 634050

kulikov.es@ssmu.ruhttps://orcid.org/0000-0001-7532-7102БойковВ. А.BoykovV. A.

Бойков Вадим Андреевич, д-р мед. наук, доцент, заведующий кафедрой организации здравоохранения и общественного здоровья

634050, Томск, Московский тракт, 2

Vadim A. Boykov, Dr. Sci. (Med.), Associate Professor, Head of the Department Healthcare and Public Health Management

2, Moskovskiy tract str., Tomsk, 634050

boykov85@mail.ruhttps://orcid.org/0000-0003-2098-2964НестеровичС. В.NesterovichS. V.

Нестерович Софья Владимировна, канд. мед. наук, главный врач клиник

634050, Томск, Московский тракт, 2

Sofia V. Nesterovich, Cand. Sci. (Med.), Chief Physician, Clinic 

2, Moskovskiy tract str., Tomsk, 634050

snesterovich@mail.ruhttps://orcid.org/0000-0001-6958-6423ПерфильевВ. Ю.PerfilevV. Yu.

Перфильев Вячеслав Юрьевич, канд. мед. наук, доцент кафедры фармакологии

634050, Томск, Московский тракт, 2

Vyacheslav Yu. Perfilev, Cand. Sci. (Med.), Associate Professor, Department of Pharmacology

2, Moskovskiy tract str., Tomsk, 634050

p.v.yu@mail.ruСибирский государственный медицинский университет (СибГМУ) Министерства здравоохранения Российской ФедерацииРоссияSiberian State Medical UniversityRussian FederationЮжно-Уральский государственный медицинский университет (ЮУГМУ) Министерства здравоохранения Российской ФедерацииРоссияSouth Ural State Medical UniversityRussian Federation2024040420243912837Copyright © Перфильева Д.Ю., Мирошниченко А.Г., Куликов Е.С., Бойков В.А., Нестерович С.В., Перфильев В.Ю., 20242024Перфильева Д.Ю., Мирошниченко А.Г., Куликов Е.С., Бойков В.А., Нестерович С.В., Перфильев В.Ю.Perfileva D.Y., Miroshnichenko A.G., Kulikov E.S., Boykov V.A., Nesterovich S.V., Perfilev V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/2181

Антибиотикорезистентность представляет серьезную угрозу для общественного здравоохранения. С антибиотикорезистентностью неразрывно связана проблема внутрибольничных инфекций (ВБИ). ВБИ в большинстве случаев обусловлены формированием и распространением госпитальных штаммов, обладающих резистентностью к антибактериальным препаратам (АБП). ВБИ, вызванные полирезистентными микроорганизмами, увеличивают расходы на здравоохранение, повышают длительность госпитализации и определяют крайне неблагоприятный исход для пациента. В статье систематизированы данные о распространенности ВБИ, рассмотрена проблема антибиотикорезистентности ведущих внутрибольничных патогенов. Проанализированы подходы к мониторингу и управлению антибиотикорезистентностью, эпидемиологическому наблюдению за ВБИ. Рассмотрена перспективная область исследования в общественном здравоохранении – ВБИ, связанные с предшествующей госпитализацией.

Antibiotic resistance poses a serious threat to public health. The problem of nosocomial infections is inextricably linked with antibiotic resistance. Nosocomial infections in most cases are caused by the formation and spread of hospital strains that are resistant to antibacterial drugs. Nosocomial infections caused by multidrug-resistant microorganisms increase healthcare costs, lengthen hospital stays, and lead to extremely poor patient outcomes. The article systematizes data on the prevalence of nosocomial infections and examines the problem of antibiotic resistance of leading nosocomial pathogens. Approaches to monitoring and management of antibiotic resistance and epidemiological surveillance of nosocomial infections are analyzed. A promising area of research in public health is considered – osocomial infections associated with previous hospitalization.

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The authors declare that there are no conflicts of interest present.