cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2025-771cardiotomsk-2234Research ArticleОБЗОРЫREVIEWSМетаболическая активность жировых депо (обзор литературы)Metabolic activity of adipose tissue depots (literature review)https://orcid.org/0000-0002-4312-7621ТузовскаяО. В.TuzovskaiaO. V.

Тузовская Ольга Викторовна - младший научный сотрудник, лаборатория генетических и средовых детерминант жизненного цикла человека, НИИТПМ – филиал ИЦиГ СО РАН.

630089, Новосибирск, ул. Б. Богаткова, 175/1

Olga V. Tuzovskaia - Junior Research Scientist, Laboratory of Genetic and Environmental Determinants of the Human Life Cycle, IIPM – Branch of IC&G SB RAS.

175/1 B. Bogatkova str., Novosibirsk, 630089

o-nazarenko@list.ruhttps://orcid.org/0000-0001-7875-1566ХудяковаА. Д.KhudiakovaA. D.

Худякова Алена Дмитриевна - канд. мед. наук, заведующий лабораторией генетических и средовых детерминант жизненного цикла человека, НИИТПМ – филиал ИЦиГ СО РАН.

630089, Новосибирск, ул. Б. Богаткова, 175/1

Alena D. Khudiakova, Cand. Sci. (Med.), Head of the Laboratory of Genetic and Environmental Determinants of the Human Life Cycle, IIPM – Branch of IC&G SB RAS.

175/1 B. Bogatkova str., Novosibirsk, 630089

alene.elene@gmail.comhttps://orcid.org/0000-0002-4936-8362РагиноЮ. И.RaginoYu. I.

Рагино Юлия Игоревна, д-р мед. наук, профессор, чл.-корр. РАН, руководитель НИИТПМ – филиал ИЦиГ СО РАН.

630089, Новосибирск, ул. Б. Богаткова, 175/1

Yuliya I. Ragino, Dr. Sci. (Med.), Professor, Corresponding Member of the RAS, Head of the IIPM – Branch of IC&G SB RAS.

175/1 B. Bogatkova str., Novosibirsk, 630089

ragino@mail.ruНаучно-исследовательский институт терапии и профилактической медицины – филиал Федерального государственного бюджетного научного учреждения «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук» (НИИТПМ – филиал ИЦиГ СО РАН)РоссияResearch Institute of Therapy and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences Russian Federation (IIPM – Branch of IC&G SB RAS)Russian Federation2026050420264114754Copyright © Тузовская О.В., Худякова А.Д., Рагино Ю.И., 20262026Тузовская О.В., Худякова А.Д., Рагино Ю.И.Tuzovskaia O.V., Khudiakova A.D., Ragino Y.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/2234

Жировая ткань (ЖТ) привлекает все больше внимания исследователей с позиции эндокринного органа, реализующего свои функции через широкий спектр биомолекул, носящих название «адипокины» («адипоцитокины»). Дисфункция ЖТ, наблюдаемая на фоне ожирения, приводит к патологической секреции данных биомолекул, что служит причиной развития сердечно-сосудистых заболеваний (ССЗ) атеросклеротического генеза, сахарного диабета 2-го типа (СД2), дислипидемии. В обзоре представлены последние данные об основных депо ЖТ, их клеточном составе, ключевых функциях, а также результаты исследований в области метаболической активности ЖТ различных локализаций. Для поиска литературы использовались базы данных PubMed и Google Scholar. Были включены исследования, проведенные на пациентах в возрасте старше 18 лет. В анализ не вошли обзоры, исследования на животных, исследования медикаментозных препаратов, а также не оценивалось влияние диеты и хирургического лечения ожирения.

Adipose tissue is attracting more and more attention of researchers from the position of an endocrine organ that implements its functions through a wide range of biomolecules called adipokines (adipocytokines). The dysfunction of adipose tissue with obesity leads to pathological secretion of these biomolecules, which causes the development of cardiovascular diseases of atherosclerotic genesis, type 2 diabetes mellitus, dyslipidemia. The review presents the latest data on the main adipose tissue depots, their cellular composition, key functions, as well as recent studies in the field of metabolic activity of adipose tissue of various localizations. PubMed and Google Scholar databases were used to search for literature. Studies conducted on patients over the age of 18 were included. The analysis did not include reviews, animal studies, drug studies, and the effects of diet and surgical treatment of obesity were not evaluated.

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The authors declare that there are no conflicts of interest present.