cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2024-39-4-18-25cardiotomsk-2260Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESДисфункция периваскулярной жировой ткани при метаболическом синдроме и ожирении: роль газотрансмиттера сероводорода (обзор литературы)Dysfunction of perivascular adipose tissue in metabolic syndrome and obesity: the role of the gasotransmitter hydrogen sulfide (review)https://orcid.org/0000-0003-1237-9786БирулинаЮ. Г.BirulinaJ. G.

Бирулина Юлия Георгиевна, канд. биол. наук, доцент кафедры биофизики и функциональной диагностики, 

634050, Томск, Московский тракт, 2

Julia G. Birulina, Cand. Sci. (Biol.), Associate Professor, Biophysics and Functional Diagnostics Division, 

2, Moskovsky trakt, Tomsk, 634050

birulina20@yandex.ruhttps://orcid.org/0000-0001-9478-3429ВоронковаО. В.VoronkovaO. V.

Воронкова Ольга Владимировна, д-р мед. наук, доцент, заведующий кафедрой биологии и генетики, 

634050, Томск, Московский тракт, 2

Olga V. Voronkova, Dr. Sci. (Med.), Head of Biology and Genetics Division, 

2, Moskovsky trakt, Tomsk, 634050

voronkova-ov@yandex.ruhttps://orcid.org/0000-0001-9348-4945ИвановВ. В.IvanovV. V.

Иванов Владимир Владимирович, канд. биол. наук, руководитель центра доклинических исследований центральной научно-исследовательской лаборатории, 

634050, Томск, Московский тракт, 2

Vladimir V. Ivanov, Cand. Sci. (Biol.), Head of the Сenter of Preclinical Studies, Central Research Laboratory, 

2, Moskovsky trakt, Tomsk, 634050

ivanovvv1953@gmail.comhttps://orcid.org/0000-0002-6714-1938БуйкоЕ. Е.BuykoE. E.

Буйко Евгений Евгеньевич, младший научный сотрудник, центральная научно-исследовательская лаборатория,

634050, Томск, Московский тракт, 2

Evgeny E. Buyko, Junior Research Scientist, Central Research Laboratory,

2, Moskovsky trakt, Tomsk, 634050

buykoevgen@yandex.ruhttps://orcid.org/0000-0002-4008-5606ЧернышовН. А.ChernyshovN. A.

Чернышов Никита Алексеевич, ассистент кафедры биологии и генетики, 

634050, Томск, Московский тракт, 2

Nikita A. Chernyshov, Assistant Professor, Biology and Genetics Division, 

2, Moskovsky trakt, Tomsk, 634050

nchernyschov@mail.ruhttps://orcid.org/0000-0001-5047-8668ГусаковаС. В.GusakovaS. V.

Гусакова Светлана Валерьевна, д-р мед. наук, доцент, заведующий кафедрой биофизики и функциональной диагностики, 

634050, Томск, Московский тракт, 2

Svetlana V. Gusakova, Dr. Sci. (Med.), Head of Biophysics and Functional Diagnostics Division, 

2, Moskovsky trakt, Tomsk, 634050

gusacova@yandex.ruhttps://orcid.org/0000-0002-9269-0170КовалевИ. В.KovalevI. V.

Ковалев Игорь Викторович, д-р мед. наук, профессор кафедры биофизики и функциональной диагностики,

634050, Томск, Московский тракт, 2

Igor V. Kovalev, Dr. Sci. (Med.), Professor, Biophysics and Functional Diagnostics Division, 

2, Moskovsky trakt, Tomsk, 634050

kovalew@mail.ruСибирский государственный медицинский университет Министерства здравоохранения Российской Федерации (СибГМУ Минздрава России)РоссияSiberian State Medical University of the Ministry of Health of the Russian Federation (SSMU)Russian Federation202430122024394Выпуск 2024_41825Copyright © Бирулина Ю.Г., Воронкова О.В., Иванов В.В., Буйко Е.Е., Чернышов Н.А., Гусакова С.В., Ковалев И.В., 20242024Бирулина Ю.Г., Воронкова О.В., Иванов В.В., Буйко Е.Е., Чернышов Н.А., Гусакова С.В., Ковалев И.В.Birulina J.G., Voronkova O.V., Ivanov V.V., Buyko E.E., Chernyshov N.A., Gusakova S.V., Kovalev I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/2260

Необходимость разработки новых подходов для диагностики, лечения и профилактики сердечно-сосудистых заболеваний (CCЗ), ассоциированных с метаболическим синдромом и ожирением, ставит перед фундаментальной наукой задачу по поиску эффективных соединений для патогенетически обоснованной коррекции возникающих нарушений. По мере того как появляется все больше сведений о механизмах, лежащих в основе патогенеза ССЗ, особое внимание уделяется роли периваскулярной жировой ткани (ПВЖТ) в поддержании гомеостаза сердечно-сосудистой системы. ПВЖТ представляет собой метаболически активный эндокринный элемент, способный регулировать тонус кровеносных сосудов, функцию эндотелия, рост и пролиферацию сосудистых гладкомышечных клеток. Однако при метаболической патологии происходит нарушение функциональной активности клеточных элементов ПВЖТ и баланса продуцируемых ими вазоактивных веществ, что способствует возникновению и прогрессированию ССЗ. В обзоре систематизированы данные о морфофункциональных изменениях ПВЖТ при метаболическом синдроме и ожирении, рассмотрена проблема дисфункции ПВЖТ как патогенетического фактора сердечно-сосудистой патологии, проанализированы существующие сведения о газовом трансмиттере сероводороде (H2S), продуцируемом ПВЖТ, как перспективном вазорегуляторном агенте.

The development of novel strategies for diagnosing, treating, and preventing cardiovascular diseases (CVDs) linked to metabolic syndrome and obesity presents a significant challenge for the scientific community. There is a pressing need to identify effective compounds that target the underlying pathogenic mechanisms of these disorders. Increasing knowledge about the pathogenesis of CVDs has highlighted the crucial role of perivascular adipose tissue (PVAT) in maintaining cardiovascular homeostasis. PVAT is a metabolically active endocrine organ that plays a key role in regulating blood vessel tone, endothelial function, and the growth and proliferation of vascular smooth muscle cells. However, in metabolic disorders, there is a disruption in the functional activity of PVAT cellular components and an imbalance in the production of vasoactive substances, leading to the development and progression of CVDs. This review systematically examines the morphofunctional changes in PVAT associated with metabolic syndrome and obesity, emphasizes the dysfunction of PVAT as a key pathogenetic factor in cardiovascular disease, and evaluates the potential of hydrogen sulfide (H2S) produced by PVAT as a promising vasoregulatory agent based on existing data.

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The authors declare that there are no conflicts of interest present.