cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2024-39-3-34-40cardiotomsk-2422Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРоль L-аргинина как донора оксида азота и перспективы его применения: обзор литературыThe role of L-arginine as a donor of nitric oxide and the prospects for its use: the reviewМаргиеваО. И.MargievaO. I.

Маргиева Ольга Ивановна, младший научный сотрудник, лаборатория патобиохимии

362025, Владикавказ, ул. Пушкинская, 47

Olga I. Margieva, Junior Research Scientist, Laboratory of Pathobiochemistry

47, Pushkinskaya str., Vladikavkaz, 362025

margievaolga@mail.ruМаргиеваМ. Т.MargievaM. T.

Маргиева Милана Тамазиевна, студент

362025, Владикавказ, ул. Пушкинская, 40

Milana T. Margieva, Student

40, Pushkinskaya str., Vladikavkaz, 362025

555milana555@mail.ruИнститут биомедицинских исследований – филиал Федерального государственного бюджетного учреждения науки Федерального научного центра «Владикавказский научный центр Российской академии наук» (ИБМИ ВНЦ РАН)РоссияInstitute of Biomedical Investigations – the Affiliate of Vladikavkaz Scientific Centre of the Russian Academy of Sciences, Institute of Biomedical Investigations the Affilliate of Vladikavkaz Scientific Centre of the Russian Academy of SciencesRussian FederationСеверо-Осетинская государственная медицинская академия Министерства здравоохранения Российской Федерации (ФГБОУ ВО СОГМА Минздрава России)РоссияNorth Ossetian State Medical Academy of the Ministry of Health of the Russian FederationRussian Federation2024011020243933440Copyright © Маргиева О.И., Маргиева М.Т., 20242024Маргиева О.И., Маргиева М.Т.Margieva O.I., Margieva M.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/2422

В статье обсуждаются исследования, проводимые в последнее время, которые посвящены эффективному и безопасному использованию аминокислоты L-аргинин в лечебных целях при различных патологиях. Установлена практическая значимость его применения в качестве источника оксида азота (NO). Показана физиологическая роль NO – основного сосудорасширяющего средства. Выявлено, что его дефицит является ключевым звеном развития эндотелиальной дисфункции. Проведен анализ современных исследований, подтверждающих эффективность включения в терапию L-аргинина как донора NO. Многочисленные данные показывают, что пероральное введение L-аргинина в физиологических пределах может принести пользу здоровью человека за счет увеличения синтеза NO и, следовательно, кровотока в тканях.

The article discusses recent research on the effective and safe use of the amino acid L-arginine for medicinal purposes in various pathologies. The practical significance of using L-arginine as a source of nitric oxide is considered. The physiological role of nitric oxide, the main vasodilator, was shown, and its deficiency was found to be a key link in endothelial dysfunction. An analysis of modern studies confirming the effectiveness of L-arginine as a donor of nitric oxide was carried out. Ample evidence suggests that oral administration of L-arginine, within physiological limits, can benefit human health by increasing NO synthesis and hence tissue blood flow.

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The authors declare that there are no conflicts of interest present.