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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский журнал клинической и экспериментальной медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian Journal of Clinical and Experimental Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2713-2927</issn><issn pub-type="epub">2713-265X</issn><publisher><publisher-name>TSU publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29001/2073-8552-2022-765</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiotomsk-2479</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Особенности билатеральных отолитовых реакций у пациентов с нарушением равновесия вестибулярного генеза</article-title><trans-title-group xml:lang="en"><trans-title>Specific features of bilateral otolith manifestations in patients with vestibular balance disorder</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4740-0162</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гребенюк</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Grebenuk</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гребенюк Олег Валерьевич, старший научный сотрудник, лаборатория моделирования физических процессов в биологии и медицине, 634050, Томск, пр. Ленина, 36</p><p>канд. мед. наук, доцент, кафедра неврологии и нейрохирургии, 634050, Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>Oleg V. Grebenuk, Cand. Sci. (Med.), Associate Professor, Department of Neurology and Neurosurgery, 36, Lenin Ave., Tomsk, 634050;</p><p>Senior Research Scientist, 2, Moskovsky trakt, Tomsk, 634050</p></bio><email xlink:type="simple">oleg129129@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0990-2580</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Светлик</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Svetlik</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Светлик Михаил Васильевич, канд. биол. наук, доцент, кафедра физиологии человека и животных, </p><p>634050, Томск, пр. Ленина, 36</p></bio><bio xml:lang="en"><p>Mikhail V. Svetlik, Cand. Sci. (Biol.), Associate Professor, Department of Human and Animal Physiology, Senior Research Scientist,</p><p>36, Lenin Ave., Tomsk, 634050</p></bio><email xlink:type="simple">mihasv@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4140-3223</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алифирова</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Alifirova</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алифирова Валентина Михайловна, д-р мед. наук, профессор, заведующий кафедрой неврологии и нейрохирургии, </p><p>634050, Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>Valentina M. Alifirova, Dr. Sci. (Med.), Professor, Department of Neurology and Neurosurgery,</p><p>2, Moskovsky trakt, Tomsk, 634050</p></bio><email xlink:type="simple">V_Alifirova@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2183-5811</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демкин</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Demkin</surname><given-names>V. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Демкин Владимир Петрович, д-р физ.-мат. наук, профессор, кафедра общей и экспериментальной физики,</p><p>634050, Томск, пр. Ленина, 36</p></bio><bio xml:lang="en"><p>Vladimir P. Demkin, Dr. Sci. (Phis.-Mat.), Professor, Department of General and Experimental Physics,</p><p>36, Lenin Ave., Tomsk, 634050</p></bio><email xlink:type="simple">demkin@ido.tsu.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6149-4612</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акинина</surname><given-names>М. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Akinina</surname><given-names>M. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Акинина Мария Дмитриевна, аспирант, старший научный сотрудник, лаборатория моделирования физических процессов в биологии и медицине, </p><p>634050, Томск, пр. Ленина, 36</p></bio><bio xml:lang="en"><p>Maria D. Akinina, Postgraduate Student, Senior Research Scientist,</p><p>36, Lenin Ave., Tomsk, 634050</p></bio><email xlink:type="simple">maakin1993@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0431-1554</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельничук</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Melnichuk</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мельничук Сергей Васильевич, канд. физ.-мат. наук, доцент, кафедра общей и экспериментальной физики,</p><p>634050, Томск, пр. Ленина, 36</p></bio><bio xml:lang="en"><p>Sergey V. Melnichuk, Cand. Sci. (Phis.-Mat.), Associate Professor, Department of General and Experimental Physics,</p><p>36, Lenin Ave., Tomsk, 634050</p></bio><email xlink:type="simple">osbereg@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4801-7026</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Руденко</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudenko</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Руденко Татьяна Владимировна, канд. пед. наук, доцент, кафедра общей и экспериментальной физики, 634050, Томск, пр. Ленина, 36;</p><p>доцент, кафедра медицинской и биологической кибернетики, 634050, Томск, Московский тракт, 2</p></bio><bio xml:lang="en"><p>Tatiana V. Rudenko, Cand. Sci. (Ped.), Associate Professor, Department of General and Experimental Physics, 36, Lenin Ave., Tomsk, 634050; </p><p>Associate Professor, Department of Medical and Biological Cybernetics, 2, Moskovsky trakt, Tomsk, 634050</p></bio><email xlink:type="simple">rudenko@ido.tsu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5263-027X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смаглий</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smaglii</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смаглий Людмила Вячеславовна, старший научный сотрудник, лаборатория моделирования физических процессов в биологии и медицине, 634050, Томск, пр. Ленина, 36;</p><p>канд. мед. наук, доцент, кафедра биофизики и функциональной диагностики, 634050, Томск, Московский тракт, 2;</p><p>руководитель отдела эпидемиологии радиогенной патологии, 636013, Северск, пер. Чекист, 7, корп. 2</p></bio><bio xml:lang="en"><p>Lyudmila V. Smaglii, Senior Research Scientist, 36, Lenin Ave., Tomsk, 634050;</p><p>Cand. Sci. (Med.), Associate Professor, Department of Biophysics and Functional Diagnostics Division, 2, Moskovsky trakt, Tomsk, 634050; </p><p>Head of the Epidemiology of Radiation Pathology Department, Bldg. 2, 7 Chekist Lane, Seversk, 636013</p></bio><email xlink:type="simple">lud.smagly@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7062-2871</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демкин</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Demkin</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Демкин Олег Владимирович, заведующий лабораторией, кафедра общей и экспериментальной физики,</p><p>634050, Томск, пр. Ленина, 36</p></bio><bio xml:lang="en"><p>Oleg V. Demkin, Head of the Laboratory, Department of General and Experimental Physics,</p><p>36, Lenin Ave., Tomsk, 634050</p></bio><email xlink:type="simple">demkinoleg81@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вишневская</surname><given-names>Я. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Vishnevskaya</surname><given-names>Ya. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вишневская Яна Борисовна, заведующий отделением неврологии,</p><p>634040, Томск, ул. Бела Куна, 3</p></bio><bio xml:lang="en"><p>Yana B. Vishnevskaya, Head of the Department of Neurology,</p><p>3 str. Bela Kuna, Tomsk, 634040</p></bio><email xlink:type="simple">yana1971vishnevskaya@gmail.com</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Труханов</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Trukhanov</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Труханов Антон Евгеньевич, врач невролог, </p><p>634040, Томск, ул. Бела Куна, 3</p></bio><bio xml:lang="en"><p>Anton E. Trukhanov, Neurologist,</p><p>3 str. Bela Kuna, Tomsk, 634040</p></bio><email xlink:type="simple">anton.kot2020@yandex.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный исследовательский Томский государственный университет (НИ ТГУ);&#13;
Сибирский государственный медицинский университет Министерства здравоохранения Российской Федерации (СибГМУ Минздрава России)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Research Tomsk State University; &#13;
Siberian State Medical University of the Ministry of Health of the Russian Federation (SSMU)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный исследовательский Томский государственный университет (НИ ТГУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Research Tomsk State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет Министерства здравоохранения Российской Федерации (СибГМУ Минздрава России)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University of the Ministry of Health of the Russian Federation (SSMU)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Национальный исследовательский Томский государственный университет (НИ ТГУ);&#13;
Сибирский государственный медицинский университет Министерства здравоохранения Российской Федерации (СибГМУ Минздрава России);&#13;
Северский биофизический научный центр Федерального медико-биологического агентства (ФГБУН СБН Центр ФМБА России)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Research Tomsk State University; &#13;
Siberian State Medical University of the Ministry of Health of the Russian Federation (SSMU); &#13;
Seversk Biophysical Research Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Медико-санитарная часть № 2 (ОГБУЗ “МСЧ № 2”)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical and Sanitary Unit No. 2</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2024</year></pub-date><volume>39</volume><issue>4</issue><issue-title>Выпуск 2024_4</issue-title><fpage>134</fpage><lpage>141</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гребенюк О.В., Светлик М.В., Алифирова В.М., Демкин В.П., Акинина М.Д., Мельничук С.В., Руденко Т.В., Смаглий Л.В., Демкин О.В., Вишневская Я.Б., Труханов А.Е., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Гребенюк О.В., Светлик М.В., Алифирова В.М., Демкин В.П., Акинина М.Д., Мельничук С.В., Руденко Т.В., Смаглий Л.В., Демкин О.В., Вишневская Я.Б., Труханов А.Е.</copyright-holder><copyright-holder xml:lang="en">Grebenuk O.V., Svetlik M.V., Alifirova V.M., Demkin V.P., Akinina M.D., Melnichuk S.V., Rudenko T.V., Smaglii L.V., Demkin O.V., Vishnevskaya Y.B., Trukhanov A.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sibjcem.ru/jour/article/view/2479">https://www.sibjcem.ru/jour/article/view/2479</self-uri><abstract><p>Билатеральная асимметрия функции полукружных каналов лежит в основе головокружения и нарушения равновесия (НР) вестибулярного генеза. Согласно традиционному представлению, дисфункция отолитов не оказывает существенного влияния на клиническую картину у лиц с периферическими вестибулярными расстройствами. В последние годы возрос интерес к изучению вклада вестибулярной функции в контроль позы и движений, однако исследований, посвященных изучению реактивности отолитовых органов при НР вестибулярного генеза, в доступной литературе не найдено.</p><sec><title>Цель исследования</title><p>Цель исследования: изучение билатеральных отолитовых реакций у пациентов с НР вестибулярного генеза методом цервикальных вестибулярных вызванных миогенных потенциалов (цВВМП).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Клиническое обследование проведено у 63 пациентов с жалобами на головокружение и НР, госпитализированных в экстренном и плановом порядке в неврологические отделения клиник ФГБОУ ВО СибГМУ Минздрава России и Медико-санитарной части № 2 г. Томска. Из общей группы для оценки вестибулярной функции были отобраны 28 пациентов (8 мужчин и 20 женщин в возрасте от 22 до 84 лет) с хронической и эпизодической вестибулярной дисфункцией вне связи с острым или прогрессирующим неврологическим заболеванием и воспалительной патологией внутреннего уха. Средний возраст составил 63,87 ± 11,52 и 57,2 ± 18,5 года для мужчин и женщин соответственно.</p></sec><sec><title>Результаты</title><p>Результаты. Жалобы на головокружение предъявляли 27 пациентов (96,4%). Системное головокружение, характеризующееся ощущением вращения предметов вокруг обследуемого, было выявлено у 29,63%, несистемное головокружение, включая чувство «проваливания» – у 81,48% пациентов. Оба типа жалоб проявились у 10,71% обследованных, что позволило выявить 2 группы пациентов: А – с хроническими вестибулярными нарушениями (7 пациентов), Б – с эпизодическими вестибулярными нарушениями (21 пациент). В ходе исследования групп пациентов были обнаружены различия в амплитудах цВВМП латентности P13 и коэффициенте вестибулярной асимметрии между группами А и Б, а также отсутствие разницы амплитуд в группе А и наличие разницы в группе Б справа.</p></sec><sec><title>Заключение</title><p>Заключение. Несмотря на то, что пациенты обращались с преимущественно одной жалобой на головокружение, клинический и инструментальный тесты вестибулярной дисфункции показали наличие повреждений как полукружных каналов, так и отолитовых органов; асимметрию вестибулярных рефлексов и / или двухстороннее поражение вестибулярных органов. Результаты исследования позволяют рассматривать метод цВВМП как один из методов объективной оценки состояния отолитового аппарата у пациентов с нарушением вестибулярной функции. В связи с этим рекомендуется применение данного метода в обычной неврологической практике.</p></sec></abstract><trans-abstract xml:lang="en"><p>Bilateral asymmetry in the function of the semicircular canals underlies dizziness and vestibular balance disorders. According to the traditional view, otolith dysfunction does not have a significant effect on the clinical picture in individuals with peripheral vestibular disorders. In recent years, interest in studying the contribution of vestibular function to the control of posture and movements has increased. However, we have not identified any studies addressing the reactivity of otolith organs in vestibular balance disorders in the available literature.</p><sec><title>Aim</title><p>Aim: To study bilateral otolith reactions in patients with vestibular balance disorders using the method of cervical vestibular evoked myogenic potentials (cVEMP) in patients with episodic and chronic vestibular disorders.</p></sec><sec><title>Material and Methods</title><p>Material and Methods. A clinical examination was carried out in 63 patients complaining of dizziness and balance problems. They were hospitalized on an emergency and planned basis in the neurological departments of the clinics of the Siberian State Medical University and the Medical and Sanitary Unit No 2 in Tomsk. From the total group, 28 patients (8 men and 20 women aged from 22 to 84 years) were selected for assessment of vestibular function; the average age was 63.87 ± 11.52 years and 57.2 ± 18.5 years for men and women respectively. They had chronic and episodic vestibular dysfunction unrelated to acute or progressive neurological disease and inflammatory pathology of the inner ear.</p></sec><sec><title>Results</title><p>Results. 27 patients (96.4%) complained of dizziness. Systemic dizziness, characterized by a feeling of objects rotating around the subject, was detected in 29.63% of patients; non-systemic dizziness, including a feeling of “failing” – in 81.48%. Both types of complaints appeared in 10.71% of those examined, which made it possible to identify 2 groups of patients: Group A – with chronic vestibular disorders (7 patients) and Group B – with episodic vestibular disorders (21 patients). During the study of the groups of patients, differences were found in the amplitudes of cVEMP latency P13 and the coefficient of vestibular asymmetry between Groups A and B, as well as the absence of a difference in amplitudes in Group A and the presence of a difference in Group B on the right.</p></sec><sec><title>Conclusion</title><p>Conclusion. Despite the fact that patients presented with predominantly one complaint of dizziness, clinical and instrumental tests of vestibular dysfunction showed the presence of damage to both the semicircular canals and otolithic organs; asymmetry of vestibular reflexes and/or bilateral damage to the vestibular organs. The results of the study allow us to consider the cVEMP method as one of the methods for objectively assessing the condition of the otolithic apparatus in patients with impaired vestibular function. In this regard, it is recommended to use this method in routine neurological practice.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>билатеральная асимметрия</kwd><kwd>вестибулярный орган</kwd><kwd>отолитовые органы</kwd><kwd>полукружные каналы</kwd><kwd>вестибулярные вызванные миогенные потенциалы</kwd><kwd>электромиография</kwd><kwd>вестибулярные нарушения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bilateral asymmetry</kwd><kwd>vestibular organ</kwd><kwd>otolith organs</kwd><kwd>semicircular canals</kwd><kwd>vestibular evoked myogenic potentials</kwd><kwd>electromyography</kwd><kwd>vestibular disorders</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено за счет гранта Российского научного фонда № 23-25-00259; https://rscf.ru/project/23-25-00259/.</funding-statement><funding-statement xml:lang="en">The study was supported by Russian Science Foundation grant No. 23-25-00259 (https://rscf. ru/project/23-25-00259/).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Halmagyi G.M., Curthoys I.S., Dai M.J. 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