cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2017-32-1-19-23cardiotomsk-261Research ArticleКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯCLINICAL STUDIESИЗМЕНЕНИЕ КОНЦЕНТРАЦИЙ РЕНИНА И АЛЬДОСТЕРОНА В ЗАВИСИМОСТИ ОТ ДИНАМИКИ АРТЕРИАЛЬНОГО ДАВЛЕНИЯ В ОТДАЛЕННЫЕ СРОКИ ПОСЛЕ РЕНАЛЬНОЙ ДЕНЕРВАЦИИ У БОЛЬНЫХ РЕЗИСТЕНТНОЙ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙRENIN AND ALDOSTERONE CONCENTRATIONS CHANGE DEPENDING ON THE ARTERIAL BLOOD PRESSURE LONG-TERM AFTER RENAL DENERVATION IN PATIENTS WITH RESISTANT HYPERTENSIONЗюбановаИ. В.ZyubanovaI. V.

аспирант отделения артериальных гипертоний Научно-исследовательского института кардиологии, Томский национальный исследовательский медицинский  центр Российской академии наук

Адрес: 634012, г. Томск, ул. Киевская, 111а

zyubanovaiv@mail.ruМордовинВ. Ф.MordovinV. F.

докт. мед. наук, профессор, руководитель отделения артериальных гипертоний  Научноисследовательского института кардиологии, Томский национальный  исследовательский медицинский центр Российской академии наук

Адрес: 634012, г. Томск, ул. Киевская, 111а

mordovin@cardio.tsu.ruНаучно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наукРоссияCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesRussian Federation2017031020173211923Copyright © Зюбанова И.В., Мордовин В.Ф., 20172017Зюбанова И.В., Мордовин В.Ф.Zyubanova I.V., Mordovin V.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/261

Метод транскатетерной симпатической денервации почечных артерий в последние годы широко используется во всем мире для лечения пациентов с резистентной артериальной гипертензией (АГ). Вместе с тем большое количество вопросов остается в связи с механизмами гипотензивного действия процедуры и длительностью терапевтического эффекта от вмешательства. Реализация эффектов радиочастотной аблации (РЧА) почечных артерий закономерно рассматривается через снижение симпатического влияния на почки и уменьшение активности ренинангиотензин-альдостероновой системы (РААС). Предварительные исследования на животных констатировали значимые снижения уровней ренина и альдостерона после ренальной денервации вместе со снижением артериального давления (АД). При этом каких-либо изменений со стороны этих гормонов у пациентов после оперативного лечения в литературе не описано. Отдаленные эффекты катетерной денервации почек остаются также малоизученными.

In recent years, the method of renal arteries transcatheter sympathetic denervation for treating patients with resistant hypertension has been used worldwide. At the same time, many questions about the procedure of hypotensive mechanisms and therapeutic effect duration still remain without answers. The effects of radiofrequency ablation of renal arteries are considered to occur through downregulation of sympathetic effects on the kidneys and decrease in renin–angiotensin–aldosterone system activity. Preclinical animal studies confirmed significant decreases in the renin and aldosterone levels after renal denervation along with lowering blood pressure. However, no data are available regarding the changes in the levels of these hormones in patients after the operative treatment. Long-term effects of catheter renal denervation remain also insufficiently explored.

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The authors declare that there are no conflicts of interest present.