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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский журнал клинической и экспериментальной медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian Journal of Clinical and Experimental Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2713-2927</issn><issn pub-type="epub">2713-265X</issn><publisher><publisher-name>TSU publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29001/2073-8552-2025-40-1-42-50</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiotomsk-2631</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Возможности биоимпедансного анализа для диагностики компонентов остеосаркопенического ожирения</article-title><trans-title-group xml:lang="en"><trans-title>Potential of bioimpedance analysis for diagnostics of osteosarcopenic obesity components</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6136-0518</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цыганкова</surname><given-names>Д. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsygankova</surname><given-names>D. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цыганкова Дарья Павловна, д-р мед. наук, ведущий научный сотрудник, лаборатория эпидемиологии сердечно-сосудистых заболеваний</p><p>650002, Кемерово, бульвар имени академика Л.С. Барбараша, 6</p></bio><bio xml:lang="en"><p>Darya P. Tsygankova, Dr. Sci. (Med.), Leading Research Scientist, Laboratory of Epidemiology of Cardiovascular Diseases</p><p>6, Boulevard named after Academician L.S. Barbarasha, Kemerovo, 650002</p></bio><email xlink:type="simple">darjapavlovna2014@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2384-5682</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кривошапова</surname><given-names>К. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Krivoshapova</surname><given-names>K. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кривошапова Кристина Евгеньевна, канд. мед. наук, научный сотрудник, лаборатория коморбидности сердечно-сосудистых заболеваний</p><p>650002, Кемерово, бульвар имени академика Л.С. Барбараша, 6</p></bio><bio xml:lang="en"><p>Kristina E. Krivoshapova, Cand. Sci. (Med.), Research Scientist, Laboratory of Pathophysiology of Multifocal Atherosclerosi</p><p>6, Boulevard named after Academician L.S. Barbarasha, Kemerovo, 650002</p></bio><email xlink:type="simple">cigadp@kemcardio.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3023-6239</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баздырев</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Bazdyrev</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баздырев Евгений Дмитриевич, д-р мед. наук, заведующий лабораторией эпидемиологии сердечно-сосудистых заболеваний</p><p>650002, Кемерово, бульвар имени академика Л.С. Барбараша, 6</p></bio><bio xml:lang="en"><p>Evgeniy D. Bazdyrev, Dr. Sci. (Med.), Head of the Laboratory of Epidemiology of Cardiovascular Diseases</p><p>6, Boulevard named after Academician L.S. Barbarasha, Kemerovo, 650002</p></bio><email xlink:type="simple">bazded@kemcardio.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6004-4852</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кареева</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kareeva</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кареева Анастасия Ильясовна, младший научный сотрудник, лаборатория лучевых методов диагностики</p><p>650002, Кемерово, бульвар имени академика Л.С. Барбараша, 6</p></bio><bio xml:lang="en"><p>Anastasia I. Kareeva, Junior Research Scientist, Laboratory of Radiation Diagnostic Methods, Scientific </p><p>6, Boulevard named after Academician L.S. Barbarasha, Kemerovo, 650002</p></bio><email xlink:type="simple">cigadp@kemcardio.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2279-3307</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артамонова</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Artamonova</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Артамонова Галина Владимировна, д-р мед. наук, профессор, заведующий отделом оптимизации медицинской помощи при сердечно-сосудистых заболеваниях, заместитель директора по науке</p><p>650002, Кемерово, бульвар имени академика Л.С. Барбараша, 6</p></bio><bio xml:lang="en"><p>Galina V. Artamonova, Dr. Sci. (Med.), Professor, Head of the Department for Optimization of Medical Care for Cardiovascular Diseases, Deputy Director of the Scientific Research Institute of the CPSIS for Science</p><p>6, Boulevard named after Academician L.S. Barbarasha, Kemerovo, 650002</p></bio><email xlink:type="simple">cigadp@kemcardio.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4642-3610</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барбараш</surname><given-names>О. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Barbarash</surname><given-names>O. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Барбараш Ольга Леонидовна, д-р мед. наук, профессор, академик РАН, директор </p><p>650002, Кемерово, бульвар имени академика Л.С. Барбараша, 6</p></bio><bio xml:lang="en"><p>Olga L. Barbarash, Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Director </p><p>6, Boulevard named after Academician L.S. Barbarasha, Kemerovo, 650002</p></bio><email xlink:type="simple">palina@cardio.kem.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний Министерства здравоохранения Российской Федерации (НИИ КПССЗ Минздрава России)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute for Complex Problems of Cardiovascular Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>12</day><month>04</month><year>2025</year></pub-date><volume>40</volume><issue>1</issue><fpage>42</fpage><lpage>50</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Цыганкова Д.П., Кривошапова К.Е., Баздырев Е.Д., Кареева А.И., Артамонова Г.В., Барбараш О.Л., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Цыганкова Д.П., Кривошапова К.Е., Баздырев Е.Д., Кареева А.И., Артамонова Г.В., Барбараш О.Л.</copyright-holder><copyright-holder xml:lang="en">Tsygankova D.P., Krivoshapova K.E., Bazdyrev E.D., Kareeva A.I., Artamonova G.V., Barbarash O.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sibjcem.ru/jour/article/view/2631">https://www.sibjcem.ru/jour/article/view/2631</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. При физиологическом старении имеются все факторы, способствующие развитию ожирения, саркопении и остеопорозу за счет увеличения жировой массы, снижения мышечной массы и силы, а также снижения костной массы. Очевидно, что прямое воздействие остеосаркопенического ожирения (ОСО) представляет собой потенциальную угрозу общественному здоровью. Эффекты снижения мышечной и костной ткани в сочетании с влиянием ожирения вполне могут быть ассоциированы с худшими клиническими исходами, обусловленными каскадом метаболических нарушений, связанных с этими изменениями в составе тела.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: выявить распространенность и динамику компонентов ОСО за трехлетний период, оцененных с помощью биоимпедансного анализа.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В базовое исследование были включены 1 124 женщины и 476 мужчин. Период наблюдения составлял 3 года с момента первого визита респондента. Медиана возраста обследованного населения соответствовала 56,0 (47,0; 63,0) годам. Лица старше 65 лет составляли 17,7% на базовом этапе обследования и 31,0% на проспективном. Для определения компонентов ОСО (доля жира, костная масса) использовался анализатор жировой массы ВС-532 (Tanita Corporation, Токио, Япония). Мышечный компонент оценивался с помощью кистевой динамометрии, которая проводилась с использованием механического динамометра.</p></sec><sec><title>Результаты</title><p>Результаты. ОСО (мышечная слабость + избыточное содержание жира в организме + недостаточная костная масса) на базовом этапе встречалось одинаково часто у мужчин и женщин старше 65 лет (2,2 и 1,4% соответственно, р = 0,679); моложе 65 лет – у 0% мужчин и у 0,5% женщин (р = 0,607). На проспективном этапе наблюдалось увеличение распространенности ОСО среди населения старше 65 лет за счет женской популяции (24,1 и 1,4% у женщин и мужчин соответственно, р &lt; 0,001). Следует отметить, что среди лиц моложе 65 лет доля женщин с ОСО составляла 4,4%, в то время как среди мужчин по-прежнему не было выявлено данной патологии (р &lt; 0,001). В целом распространенность данного мультифакториального синдрома на базовом этапе составляла 0,55% и увеличилась в 14,7 раза (до 8,1%, р &lt; 0,001) во время проспективного этапа наблюдения.</p></sec><sec><title>Заключение</title><p>Заключение. С помощью биоимпедансного анализа за изучаемый период времени было выявлено, что ОСО на базовом этапе встречалось одинаково часто у мужчин и женщин старше 65 лет (2,2 и 1,4% соответственно). На проспективном этапе наблюдалось увеличение распространенности ОСО среди населения старше 65 лет за счет женской популяции (24,1 и 1,4% у женщин и мужчин соответственно). Следует отметить, что среди лиц, моложе 65 лет доля женщин с ОСО составляла 4,4%, в то время как среди мужчин не было выявлено данной патологии за весь изучаемый период времени.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Rationale</title><p>Rationale. Physiological aging has all the factors that contribute to the development of obesity, sarcopenia and osteoporosis through increased fat mass, decreased muscle mass and strength, and decreased bone mass. It is clear that the direct impact of osteosarcopenic obesity poses a potential threat to public health. The effects of muscle and bone loss, combined with the effects of obesity, may well be associated with worse clinical outcomes due to the cascade of metabolic abnormalities associated with these changes in body composition</p></sec><sec><title>Aim</title><p>Aim: To identify the prevalence and dynamics of the components of osteosarcopenic obesity over a three-year period assessed using bioimpedance analysis.</p><p>Methodology and research methods. The baseline study included 1124 women and 476 men. The follow-up period was 3 years from the date of the respondent's first visit. The median age of the study population was 56.0 (47.0; 63.0) years. Persons over 65 years old accounted for 17.7% at the baseline stage of the survey and 31.0% at the prospective stage. To determine the components of osteosarcopenic obesity (fat percentage, bone mass), a fat mass analyzer BC-532 (manufactured by Tanita Corporation, Tokyo, Japan) was used. The muscle component was assessed using hand dynamometry, which was performed using a mechanical dynamometer</p></sec><sec><title>Results</title><p>Results. Osteosarcopenic obesity (OSA, muscle weakness + excess body fat + insufficient bone mass) at baseline was equally common in men and women over 65 years of age (2.2% and 1.4%, respectively, p = 0.679). Among persons under 65 years of age – 0.5% in women and 0% in men (p = 0.607). At the prospective stage, there was an increase in the prevalence of AOM among the population over 65 years of age, due to the female population (24.1% and 1.4% in women and men, respectively, p &lt; 0.001). It should be noted that among people under 65 years of age, the proportion of women with AOM was 4.4%, while among men this pathology was still not detected (p &lt; 0.001). Overall, the prevalence of this multifactorial syndrome at baseline was 0.55% and increased 14.7-fold (to 8.1%, p &lt; 0.001) during the prospective follow-up phase.</p></sec><sec><title>Conclusion</title><p>Conclusion. Using bioimpedance analysis, over the studied period of time it was revealed that osteosarcopenic obesity at the baseline stage was equally common in men and women over 65 years of age (2.2% and 1.4%, respectively). At the prospective stage, there was an increase in the prevalence of AOM among the population over 65 years of age, due to the female population (24.1% and 1.4% in women and men, respectively). It should be noted that among people under 65 years of age, the proportion of women with AOM was 4.4%, while among men this pathology was not detected for the entire study period.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>остеосаркопеническое ожирение</kwd><kwd>пожилые</kwd><kwd>биоимпедансный анализ</kwd><kwd>состав тела</kwd><kwd>мышечная слабость</kwd><kwd>костная масса</kwd><kwd>содержание жира в организме</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteosarcopenic obesity</kwd><kwd>elderly</kwd><kwd>bioimpedance analysis</kwd><kwd>body composition</kwd><kwd>muscle weakness</kwd><kwd>bone mass</kwd><kwd>body fat content</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Средства гранта «Патофизиологические особенности формирования остеосаркопенического ожирения при мультифокальном атеросклерозе как маркера биологического старения» № 22-15-00305</funding-statement><funding-statement xml:lang="en">The study was supported by grant “Pathophysiological features of the formation of osteosarcopenic obesity in multifocal atherosclerosis as a marker of biological aging” No. 22-15-00305</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Khavinson V., Popovich I., Mikhailova O. 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