cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2025-40-1-159-165cardiotomsk-2643Research ArticleКЛИНИЧЕСКИЕ СЛУЧАИCLINICAL CASESОсобенности ведения беременности при семейной гиперхолестеринемии: клинический случайFeatures of pregnancy management with familial hypercholesterolemia: a case reporthttps://orcid.org/0000-0002-9630-0213БерезиковаЕ. Н.BerezikovaE. N.

Березикова Екатерина Николаевна, д-р мед. наук, профессор кафедры внутренних болезней им. акад. Л.Д. Сидоровой

630091, Новосибирск, Красный пр-т, 52 

Ekaterina N. Berezikova, Dr. Sci. (Med.), Professor, Internal Diseases Department

52, Krasniy pr., Novosibirsk, 630091

cardio@enberezikova.ruhttps://orcid.org/0000-0002-7777-6419ШиловС. Н.ShilovS. N.

Шилов Сергей Николаевич, д-р мед. наук, профессор кафедры патологической физиологии и клинической патофизиологии

630091, Новосибирск, Красный пр-т, 52 

Sergey N. Shilov, Dr. Sci. (Med.), Professor, Pathological Physiology and Clinical Pathophysiology Department

52, Krasniy pr., Novosibirsk, 630091

newsib54@gmail.comhttps://orcid.org/0000-0002-4736-6486ЯковлеваН. Ф.YakovlevaN. F.

Яковлева Наталья Фаритовна, канд. мед. наук, ассистент кафедры поликлинической терапии и общей врачебной практики

630091, Новосибирск, Красный пр-т, 52 

Natalia F. Yakovlevа, Cand. Sci. (Med.), Assistant Professor, Department of Policlinic Therapy and General Medical Practice

52, Krasniy pr., Novosibirsk, 630091

yakovlevanf@yandex.ruhttps://orcid.org/0000-0003-0207-7063ЦыганковаО. В.TsygankovaO. V.

Цыганкова Оксана Васильевна, д-р мед. наук, профессор кафедры неотложной терапии с эндокринологией и профпатологией (ФПК и ППВ)

630091, Новосибирск, Красный пр-т, 52 

Oksana V. Tsygankova, Dr. Sci. (Med.), Professor of the Department of Emergency Therapy with Endocrinology and Occupational Pathology

52, Krasniy pr., Novosibirsk, 630091

oksana_c.nsk@mail.ruhttps://orcid.org/0000-0002-6095-1954ПасманН. М.PasmanN. M.

Пасман Наталья Михайловна, д-р мед. наук, профессор, заведующий кафедрой акушерства и гинекологии, лечебный факультет

630090, Новосибирск, ул. Пирогова, 2

Natalia M. Pasman, Dr. Sci. (Med.), Professor, Head of the Department of Obstetrics and Gynecology

2, Pirogova str., Novosibirsk 630090

oksana_c.nsk@mail.ruНовосибирский государственный медицинский университет Министерства здравоохранения Российской Федерации (НГМУ Минздрава России)РоссияNovosibirsk State Medical University (NSMU)Russian FederationНовосибирский национальный исследовательский государственный университет (НГУ)РоссияNational Research Novosibirsk State University (NSU)Russian Federation202513042025401159165Copyright © Березикова Е.Н., Шилов С.Н., Яковлева Н.Ф., Цыганкова О.В., Пасман Н.М., 20252025Березикова Е.Н., Шилов С.Н., Яковлева Н.Ф., Цыганкова О.В., Пасман Н.М.Berezikova E.N., Shilov S.N., Yakovleva N.F., Tsygankova O.V., Pasman N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/2643

Семейная гиперхолестеринемия (СГХЭ) – аутосомно-доминантное нарушение липидного обмена, приводящее к повышению уровня холестерина липопротеинов низкой плотности (ЛПНП) в плазме с последующим преждевременным атеросклерозом. У женщин с СГХЭ беременность и лактация представляют дополнительный риск из-за связи физиологических изменений, ранее существовавшей дислипидемии и ограниченных терапевтических возможностей и опыта. Представлен клинический случай успешного ведения беременной женщины с СГХЭ на фоне мультифокального атеросклероза с оценкой динамики липидного профиля в разные сроки беременности и после родов.

Familial hypercholesterolemia is an autosomal dominant disorder of lipid metabolism, leading to an increase in plasma low-density lipoprotein cholesterol, followed by premature atherosclerosis. In women with familial hypercholesterolemia, pregnancy and lactation pose an additional risk due to the association of physiological changes, pre-existing dyslipidemia, and limited therapeutic options and experience. A clinical case of successful management of a pregnant woman with familial hypercholesterolemia against the background of multifocal atherosclerosis with an assessment of the dynamics of the lipid profile at different stages of pregnancy and after childbirth is presented.

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The authors declare that there are no conflicts of interest present.