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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский журнал клинической и экспериментальной медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian Journal of Clinical and Experimental Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2713-2927</issn><issn pub-type="epub">2713-265X</issn><publisher><publisher-name>TSU publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29001/2073-8552-2025-40-1-166-176</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiotomsk-2645</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Клинический случай тяжелой недостаточности аортального клапана вследствие анкилозирующего спондилита</article-title><trans-title-group xml:lang="en"><trans-title>Clinical case of severe aortic valve insufficiency due to ankylosing spondyloarthritis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3294-6568</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Реброва</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rebrova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Реброва Наталья Васильевна, канд. мед. наук, заведующий отделением атеросклероза и хронической ишемической болезни сердца</p><p>634012, Томск, ул. Киевская, 111а</p></bio><bio xml:lang="en"><p>Natalya V. Rebrova, Cand. Sci. (Med.), Head of the Department of Atherosclerosis and Coronary Artery Disease</p><p>111a, Kievskaya str., Tomsk, 634012</p></bio><email xlink:type="simple">rebrova2009@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6850-182X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крапивина</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Krapivina</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крапивина Анастасия Сергеевна, лаборант-исследователь, отделение атеросклероза и хронической ишемической болезни сердца</p><p>634012, Томск, ул. Киевская, 111а</p></bio><bio xml:lang="en"><p>Anastasia S. Krapivina, Laboratory Research Assistant, Department of Atherosclerosis and Coronary Artery Disease</p><p>111a, Kievskaya str., Tomsk, 634012</p></bio><email xlink:type="simple">ya.anastasiya.krapivina99@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7161-4622</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Связова</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sviazova</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Связова Наталья Николаевна, канд. мед. наук, врач ультразвуковой диагностики, младший научный сотрудник, отделение атеросклероза и хронической ишемической болезни сердца</p><p>634012, Томск, ул. Киевская, 111а</p></bio><bio xml:lang="en"><p>Natalia N. Sviazova, Cand. Sci. (Med.), Ultrasound Diagnostics Doctor, Junior Research Scientist, Department of Atherosclerosis and Coronary Artery Disease</p><p>111a, Kievskaya str., Tomsk, 634012</p></bio><email xlink:type="simple">gladkihn@cardio-tomsk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щербань</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shcherban</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щербань Наталья Викторовна, врач-рентгенолог, кабинет рентгеновской компьютерной томографии, отделение рентгеновских и томографических методов диагностики</p><p>634012, Томск, ул. Киевская, 111а</p></bio><bio xml:lang="en"><p>Natalya V. Shcherban, Radiologist of X-ray Computed Tomography Room, Department of Radiology and Tomography</p><p>111a, Kievskaya str., Tomsk, 634012</p></bio><email xlink:type="simple">rgnatvik@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8543-6027</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанов</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Степанов Иван Вадимович, канд. мед. наук, заведующий патологоанатомическим отделением</p><p>634012, Томск, ул. Киевская, 111а</p></bio><bio xml:lang="en"><p>Ivan V. Stepanov, Cand. Sci. (Med.), Head of the Pathoanatomical Department</p><p>111a, Kievskaya str., Tomsk, 634012</p></bio><email xlink:type="simple">i_v_stepanov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2103-2437</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лихоманов</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Likhomanov</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лихоманов Константин Сергеевич, канд. мед. наук, врач-кардиолог, отделение атеросклероза и хронической ишемической болезни сердца</p><p>634012, Томск, ул. Киевская, 111а</p></bio><bio xml:lang="en"><p>Konstantin S. Likhomanov, Cand. Sci. (Med.), Cardiologist, Department of Atherosclerosis and Chronic Coronary Heart Disease</p><p>111a, Kievskaya str., Tomsk, 634012</p></bio><email xlink:type="simple">lks@cardio-tomsk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Научно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наук (НИИ кардиологии Томского НИМЦ)<country>Россия</country></aff><aff xml:lang="en">Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, Tomsk, Russia (Cardiology Research Institute, Tomsk NRMC)<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>13</day><month>04</month><year>2025</year></pub-date><volume>40</volume><issue>1</issue><fpage>166</fpage><lpage>176</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Реброва Н.В., Крапивина А.С., Связова Н.Н., Щербань Н.В., Степанов И.В., Лихоманов К.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Реброва Н.В., Крапивина А.С., Связова Н.Н., Щербань Н.В., Степанов И.В., Лихоманов К.С.</copyright-holder><copyright-holder xml:lang="en">Rebrova N.V., Krapivina A.S., Sviazova N.N., Shcherban N.V., Stepanov I.V., Likhomanov K.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sibjcem.ru/jour/article/view/2645">https://www.sibjcem.ru/jour/article/view/2645</self-uri><abstract><p>Аортит и недостаточность аортального клапана относятся к внескелетным проявлениям анкилозирующего спондилита (АС). Торпидное течение заболеваний является причиной позднего обращения за медицинской помощью на стадии необратимых изменений и выраженного нарушения функции сердечно-сосудистой и костно-мышечной систем. В статье представлен клинический случай успешного хирургического лечения тяжелой аортальной недостаточности у пациента с поздно диагностированным АС. Обсуждаются вопросы кардиоваскулярной патологии при АС, междисциплинарного взаимодействия врачей, выбора противоревматической терапии и периоперационного ведения пациента с АС с очень высоким сердечно-сосудистым риском.</p></abstract><trans-abstract xml:lang="en"><p>Aortitis and aortic valve insufficiency are referred to as extraskeletal manifestations of ankylosing spondylitis (AS). Torpid course of diseases is the reason for late seeking medical care at the stage of irreversible changes and severe dysfunction of the cardiovascular and musculoskeletal systems. The article presents a clinical case of successful surgical treatment of severe aortic valve insufficiency in a patient with late diagnosed AS. The problems of cardiovascular pathology in AS, interdisciplinary interaction of doctors, choice of antirheumatic therapy and perioperative management of a very high cardiovascular risk patient with AS are discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>анкилозирующий спондилит</kwd><kwd>недостаточность аортального клапана</kwd><kwd>аортит</kwd><kwd>сердечно-сосудистый риск</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ankylosing spondylitis</kwd><kwd>aortic valve insufficiency</kwd><kwd>aortitis</kwd><kwd>cardiovascular risk</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ward M.M. Lifetime risks of valvular heart disease and pacemaker use in patients with ankylosing spondylitis. J. Am. 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