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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский журнал клинической и экспериментальной медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian Journal of Clinical and Experimental Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2713-2927</issn><issn pub-type="epub">2713-265X</issn><publisher><publisher-name>TSU publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29001/2073-8552-2025-2667</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiotomsk-2679</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Современные и будущие стратегии лечения эректильной дисфункции после нервосберегающей роботизированной радикальной простатэктомии (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Current and future strategies for managing erectile dysfunction following nerve-sparing robot-assisted radical prostatectomy  (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5160-925X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грицкевич</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gritskevich</surname><given-names>A. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Грицкевич Александр Анатольевич, д-р мед. наук, заведующий отделением онкоурологии и урологии, НМИЦ хирургии им. А.В. Вишневского Минздрава России; профессор кафедры урологии и оперативной нефрологии с курсом онкоурологии РУДН</p><p>117997, г. Москва, ул. Большая Серпуховская, 27;117198, г. Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>Alexander A. Gritskevich, Dr. Sci. (Med.), the Head of the Urology Department; professor of the Department of Urology and Operative Nephrology with course of Oncourology of the Medical Institute</p><p>27, Bolshaya Serpukhovskaya str., Moscow, 117997;6, Miklukho-Maklaya str., Moscow, 117198</p></bio><email xlink:type="simple">grekaa@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3646-1664</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Байтман</surname><given-names>Т. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Baitman</surname><given-names>T. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Байтман Татьяна Павловна, канд. мед. наук, научный сотрудник отделения онкоурологии и урологии НМИЦ хирургии им. А.В. Вишневского Минздрава России; ассистент кафедры урологии и оперативной нефрологии с курсом онкоурологии РУДН</p><p>117997, г. Москва, ул. Большая Серпуховская, 27;117198, г. Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>Tatiana P. Baitman, Cand. Sci. (Med.), researcher of the Urology Department; assistant of the Department of Urology and Operative Nephrology with course of Oncourology of the Medical Institute</p><p>27, Bolshaya Serpukhovskaya str., Moscow, 117997;6, Miklukho-Maklaya str., Moscow, 117198</p></bio><email xlink:type="simple">bit.t@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-6626-761X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борукаев</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Borukaev</surname><given-names>A. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Борукаев Андемиркан Юриевич, аспирант </p><p>117997, г. Москва, ул. Большая Серпуховская, 27</p></bio><bio xml:lang="en"><p>Andemirkan U. Borukaev, graduate student</p><p>27, Bolshaya Serpukhovskaya str., Moscow, 117997</p></bio><email xlink:type="simple">antik.bor98@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0792-6012</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Костин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Коstin</surname><given-names>A. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Костин Андрей Александрович, д-р мед. наук, чл.-корр. РАН, профессор РАН, первый проректор – проректор по научной работе РУДН, заведующий кафедрой урологии и оперативной нефрологии с курсом онкоурологии РУДН</p><p>117198, г. Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>Andrey A. Kostin, Dr. Sci. (Med.), Professor, Corresponding Member, Russian Academy of Sciences, First Vice-Rector for research, Head of Department of Urology and Operative Nephrology with course of Oncourology of the Medical Institute</p><p>6, Miklukho-Maklaya str., Moscow, 117198</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7999-8955</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ищенко</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ishchenko</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ищенко Роман Викторович, д-р мед. наук, директор ИНВХ им. В.К. Гусака Минздрава России</p><p>283045, Донецкая Народная Республика, г.о. Донецкий, Донецк, пр-кт Ленинский, 47</p></bio><bio xml:lang="en"><p>Roman V. Ishchenko, Dr. Sci. (Med.), the Director</p><p>47, Leninsky Ave., 283045, Donetsk urban district, Donetsk, Donetsk People's Republic</p></bio><email xlink:type="simple">info@iursdn.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4542-6860</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филимонов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Philimonov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Филимонов Дмитрий Алексеевич, д-р мед. наук, доцент, заместитель директора по научной работе </p><p>283045, Донецкая Народная Республика, г.о. Донецкий, Донецк, пр-кт Ленинский, 47</p></bio><bio xml:lang="en"><p>Dmitry A. Philimonov, Dr. Sci. (Med.), associate professor, Deputy Director for Research</p><p>47, Leninsky Ave., 283045, Donetsk urban district, Donetsk, Donetsk People's Republic</p></bio><email xlink:type="simple">info@iursdn.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0174-5798</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голубицкий</surname><given-names>К. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Golubitski</surname><given-names>K. О.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Голубицкий Кирилл Олегович, канд. мед. наук, врач-хирург </p><p>283045, Донецкая Народная Республика, г.о. Донецкий, Донецк, пр-кт Ленинский, 47</p></bio><bio xml:lang="en"><p>Kirill O. Golubitski, Cand. Sci. (Med.), surgeon</p><p>47, Leninsky Ave., 283045, Donetsk urban district, Donetsk, Donetsk People's Republic</p></bio><email xlink:type="simple">info@iursdn.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глебова</surname><given-names>А. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Glebova</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Глебова Альбина Эдуардовна, сотрудник отдела экспериментальной хирургии                        </p><p>283045, Донецкая Народная Республика, г.о. Донецкий, Донецк, пр-кт Ленинский, 47    </p></bio><bio xml:lang="en"><p>Albina E. Glebova, researcher of the Department of Experimental Surgery</p><p>47, Leninsky Ave., 283045, Donetsk urban district, Donetsk, Donetsk People's Republic</p></bio><email xlink:type="simple">info@iursdn.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр хирургии имени А.В. Вишневского Министерства здравоохранения Российской Федерации; &#13;
Российский университет дружбы народов имени Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.V. Vishnevsky National Medical Research Center for Surgery; &#13;
Peoples Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр хирургии имени А.В. Вишневского Министерства здравоохранения Российской Федерации; &#13;
Российский университет дружбы народов имени Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.V. Vishnevsky National Medical Research Center for Surgery; Peoples Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр хирургии имени А.В. Вишневского Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.V. Vishnevsky National Medical Research Center for Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Российский университет дружбы народов имени Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Институт неотложной и восстановительной хирургии имени В.К. Гусака Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Emergency and Reconstructive Surgery named after V.K. Gusak</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>13</day><month>07</month><year>2025</year></pub-date><volume>40</volume><issue>2</issue><fpage>21</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Грицкевич А.А., Байтман Т.П., Борукаев А.Ю., Костин А.А., Ищенко Р.В., Филимонов Д.А., Голубицкий К.О., Глебова А.Э., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Грицкевич А.А., Байтман Т.П., Борукаев А.Ю., Костин А.А., Ищенко Р.В., Филимонов Д.А., Голубицкий К.О., Глебова А.Э.</copyright-holder><copyright-holder xml:lang="en">Gritskevich A.А., Baitman T.P., Borukaev A.U., Коstin A.А., Ishchenko R.V., Philimonov D.A., Golubitski K.О., Glebova A.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sibjcem.ru/jour/article/view/2679">https://www.sibjcem.ru/jour/article/view/2679</self-uri><abstract><p>Эректильная дисфункция (ЭД) является одним из наиболее часто развивающихся и значимо снижающих качество жизни осложнений радикальной простатэктомии (РПЭ). По данным ряда исследований, ЭД диагностируется у 60–75% пациентов после РПЭ. Применение нервосберегающей (НС) техники операции снизило частоту нарушений эрекции после РПЭ, однако полностью не решило данную проблему. Кроме того, сохранить сосудисто-нервные пучки не всегда представляется возможным по соображениям онкологической радикальности. Все вышеперечисленные факторы делают вопрос восстановления эректильной функции одним из приоритетных направлений медицинской реабилитации пациентов после радикального оперативного вмешательства по поводу рака предстательной железы (РПЖ). Разработка новых стратегий лечения ЭД после НС РПЭ, направленных на поддержание эндотелиальной функции в кавернозных артериях до завершения ремиелинизации и восстановления поврежденных кавернозных нервов, является актуальным и активно развивающимся направлением современной андрологии.</p></abstract><trans-abstract xml:lang="en"><p>Erectile dysfunction (ED) is one of the most frequently developing and significantly reducing quality of life complications of radical prostatectomy (RPE). According to the number of studies, ED is diagnosed in 60-75% of patients after the RPE. The use of nerve-sparing surgical techniques has reduced the incidence of ED after RPE, but has not completely solved this problem. In addition, it is not always possible to preserve the vascular-nerve bundles for the reason of oncological radicalism. All of the above factors make the issue of restoring erectile function one of the priority areas of medical rehabilitation of patients after the radical surgery for prostate cancer (PC). The development of new strategies for the treatment of ED after NS RP, aimed at maintaining endothelial function in the cavernous arteries until the completion of remyelination and restoration of damaged cavernous nerves, is a relevant and actively developing area of modern andrology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак предстательной железы</kwd><kwd>эректильная дисфункция</kwd><kwd>нервосберегающая простатэктомия</kwd><kwd>эндотелиальная дисфункция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>prostate cancer</kwd><kwd>erectile dysfunction</kwd><kwd>nerve-sparing prostatectomy</kwd><kwd>signaling pathways</kwd><kwd>endothelial dysfunction</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">исследование выполнено за счет гранта Российского научного фонда № 24-75-00139, https://rscf.ru/project/24-75-00139/</funding-statement><funding-statement xml:lang="en">The study was supported by a grant from the Russian Science Foundation № 24-75-00139, https://rscf.ru/project/24-75-00139/</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">I. 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