cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2025-40-2-32-43cardiotomsk-2729Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESArterial Spin Labeling: принципы и новые тенденции в реализации методаArterial Spin Labeling: principles and current trends in the implementation of the methodhttps://orcid.org/0000-0003-3082-2315ПоповВ. В.PopovV. V.

Попов Владимир Владимирович, младший научный сотрудник, МТЦ СО РАН; ассистент, кафедра фундаментальной медицины, Институт медицины и медицинских технологий, Факультет медицины и психологии В. Зельмана, НГУ

630090, Новосибирск, ул. Институтская, 3а; 630090, Новосибирск, ул. Пирогова, 1

 

Vladimir V. Popov, Junior Research Scientist, ITC SB RAS; Assistant, Department of Fundamental Medicine, Institute of Medicine and Medical Technologies, Faculty of Medicine and Psychology V. Zelman, NSU

3a, Institutskaya str., Novosibirsk, 630090;1, Pirogova str., Novosibirsk, 630090

popov.v@tomo.nsc.ruhttps://orcid.org/0000-0002-7959-5160СтанкевичЮ. А.StankevichYu. A.

Станкевич Юлия Александровна, канд. мед. наук, заведующий лабораторией функциональной нейровизуализации, старший научный сотрудник, МТЦ СО РАН; старший преподаватель, Центр постдипломного медицинского образования, Институт медицины и медицинских технологий, факультет медицины и психологии В. Зельмана, НГУ

630090, Новосибирск, ул. Институтская, 3а; 630090, Новосибирск, ул. Пирогова, 1

Yuliya A. Stankevich, Cand. Sci. (Med.), Head of the Laboratory of Functional Neuroimaging, Senior Research Scientist, ITC SB RAS; Senior Lecturer, Center for Postgraduate Medical Education, Institute of Medicine and Medical Technologies, Faculty of Medicine and Psychology V. Zelman, NSU

3a, Institutskaya str., Novosibirsk, 630090;1, Pirogova str., Novosibirsk, 630090

stankevich@tomo.nsc.ruhttps://orcid.org/0000-0002-8880-100XБогомяковаО. Б.BogomyakovaO. B.

Богомякова Ольга Борисовна, канд. мед. наук, научный сотрудник, МТЦ СО РАН; старший преподаватель, Центр постдипломного медицинского образования, Институт медицины и медицинских технологий, факультет медицины и психологии В. Зельмана, НГУ

630090, Новосибирск, ул. Институтская, 3а; 630090, Новосибирск, ул. Пирогова, 1

Olga B. Bogomyakova, Cand. Sci. (Med.), Research Scientist, ITC SB RAS; Senior Lecturer, Center for Postgraduate Medical Education, Institute of Medicine and Medical Technologies, Faculty of Medicine and Psychology V. Zelman, NSU

3a, Institutskaya str., Novosibirsk, 630090;1, Pirogova str., Novosibirsk, 630090

bogom_o@tomo.nsc.ruhttps://orcid.org/0000-0002-1277-4113ТулуповА. А.TulupovA. A.

Тулупов Андрей Александрович, д-р мед. наук, профессор, чл.корр. РАН, заведующий лабораторией нейронаук, главный научный сотрудник, МТЦ СО РАН; заместитель директора, профессор, Центр постдипломного медицинского образования, Институт медицины и медицинских технологий, факультет медицины и психологии В. Зельмана, НГУ

630090, Новосибирск, ул. Институтская, 3а; 630090, Новосибирск, ул. Пирогова, 1

Andrey A. Tulupov, Dr. Sci. (Med.), Professor, Corresponding Member of the RAS, Head of the Laboratory of Neurosciences, Chief Research Sientist, ITC SB RAS; Deputy Director, Professor, Center for Postgraduate Medical Education, Institute of Medicine and Medical Technologies, Faculty of Medicine and Psychology V. Zelman, NSU

3a, Institutskaya str., Novosibirsk, 630090;1, Pirogova str., Novosibirsk, 630090

taa@tomo.nsc.ruИнститут «Международный томографический центр» Сибирского отделения Российской академии наук; Новосибирский национальный исследовательский государственный университетРоссияThe Institute International Tomography Center of the Russian Academy of Sciences; Novosibirsk State UniversityRussian Federation2025130720254023243Copyright © Попов В.В., Станкевич Ю.А., Богомякова О.Б., Тулупов А.А., 20252025Попов В.В., Станкевич Ю.А., Богомякова О.Б., Тулупов А.А.Popov V.V., Stankevich Y.A., Bogomyakova O.B., Tulupov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/2729Цель

Цель. Изучить принципы и новые тенденции бесконтрастной магнитно-резонансной (МР) перфузии (ASL) на основе литературных данных.

Материал и методы

Материал и методы. Проведен ретроспективный обзор рандомизированных клинических и перекрестных исследований с поиском в базах данных PUBMED, EMBASE, LILACS, SCOPUS, eLIBRARY на английском и русском языках за 2014–2024 гг. Ключевые слова, используемые для выбора статей: arterial spin labeling (ASL), pulsed ASL, continuous ASL, pseudocontinuous ASL, diffusion-prepared ASL, vessel-encoded ASL, бесконтрастная магнитно-резонансная перфузия.

Результаты

Результаты. Было проанализировано 487 статей, 50 из которых использованы для составления обзора. В результате поиска созданы блоки статей, внутри которых был проведен анализ для изучения разновидностей метода ASL, технических характеристик и тенденций развития в данной области.

Заключение

Заключение. Существующие разновидности ASL позволяют осуществлять выбор и учитывать преимущества и недостатки каждого метода для проведения диагностических исследований. Последовательность псевдонепрерывной маркировки спинов артериальной крови (pseudocontinuous Arterial Spin Labeling, pCASL) является наиболее изученным, надежным и доступным количественным методом, а развивающиеся перспективные технические способы сбора и обработки результатов позволят расширить применение данного метода в клинической и исследовательской практиках.

Aim

Aim: To study the principles and new trends of contrast-free MR perfusion (ASL) based on literature data.

Material and Methods

Material and Methods. A retrospective overview of randomized clinical and crossover studies was performed by searching databases: PUBMED, EMBASE, LILACS, SCOPUS, eLIBRARY in English and Russian languages from 2015 to 2024 years. The keywords used for article selection included: arterial spin labeling (ASL), pulsed ASL, continuous ASL, pseudocontinuous ASL, diffusion-prepared ASL, artificial intelligence ASL, vessel-encoded ASL and non-contrast MR perfusion.

Results

Results. A total of 487 articles were analyzed, 50 of which were used to perform the review. The search results – blocks of articles were created with analysis the variations of the ASL method, its application possibilities, technical characteristics, and developmental trends of artificial intelligence in this field.

Conclusion

Conclusion. The existing varieties of ASL allow for the selection and consideration of the advantages and disadvantages of each method for conducting diagnostic studies. The pCASL sequence is the most studied, reliable and affordable quantitative method, and the developing promising technical methods for collecting and processing results will expand the application of the method in clinical and research practices.

arterial spin labelingPASLCASLpCASLdp-pCASLvs-ASLve-ASLбесконтрастная магнитно-резонансная перфузияarterial spin labelingPASLCASLpCASLdp-pCASLvs-ASLve-ASLnon-contrast MR perfusionРаздел, посвященный анализу возможностей ASL в изучении патогенеза инсульта, подготовлен в рамках гос. задания 1023110800234-5-3.2.25;3.1.4;3.2.12. Раздел, посвящённый описанию возможностей новых методик МРТ для оценки очагов рассеянного склероза, поддержан грантом Российского научного фонда, проект № 23-15-00377The section devoted to the analysis of ASL capabilities in the study of stroke pathogenesis was prepared within the framework of state assignment 1023110800234-5-3.2.25;3.1.4;3.2.12. The section devoted to the description of the capabilities of new MRI techniques for assessing multiple sclerosis foci was supported by a grant from the Russian Science Foundation, project No. 23-15-00377ReferencesClement P., Petr J., Dijsselhof M.J., Padrela B, Pasternak M., Dolui S. et al. 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The authors declare that there are no conflicts of interest present.