<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский журнал клинической и экспериментальной медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian Journal of Clinical and Experimental Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2713-2927</issn><issn pub-type="epub">2713-265X</issn><publisher><publisher-name>TSU publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29001/2073-8552-2025-40-3-205-211</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiotomsk-2835</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРГАНИЗАЦИЯ ЗДРАВООХРАНЕНИЯ И ОБЩЕСТВЕННОЕ ЗДОРОВЬЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEALTHCARE AND PUBLIC HEALTH</subject></subj-group></article-categories><title-group><article-title>Организационные и экономические преимущества внедрения догоспитальной предлучевой топометрической подготовки в деятельность Приморского краевого онкологического диспансера</article-title><trans-title-group xml:lang="en"><trans-title>Organizational and economic advantages of implementing pre-hospital pre-radiation topometric training in the activities of the Primorsky Regional Oncology Dispensary</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0724-9736</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петухова</surname><given-names>Ю. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Petukhova</surname><given-names>Yu. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петухова Юлия Юрьевна - канд. мед. наук, заместитель главного врача по медицинской части, ГБУЗ «ПКОД».</p><p>690105, Владивосток, ул. Русская, 59; 690922, Владивосток, о. Русский, п. Аякс, 10</p></bio><bio xml:lang="en"><p>Yulia Yu. Petukhova - Cand. Sci. (Med.), Deputy Chief Medical Officer, GBUZ PKOD.</p><p>59, Russkaya str., Vladivostok, 690105; 10, Ajax settlement, Russian island, Vladivostok, 690922</p></bio><email xlink:type="simple">juliapetukhovavl@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0472-9504</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стегний</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Stegny</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Стегний Кирилл Владимирович - д-р мед. наук, профессор, чл.корр. РАН, главный врач ГБУЗ «ПКОД».</p><p>690105, Владивосток, ул. Русская, 59; 690922, Владивосток, о. Русский, п. Аякс, 10</p></bio><bio xml:lang="en"><p>Kirill V. Stegny - Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Chief Physician, GBUZ PKOD.</p><p>59, Russkaya str., Vladivostok, 690105; 10, Ajax settlement, Russian island, Vladivostok, 690922</p></bio><email xlink:type="simple">kstegniy@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-2371-2857</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Статинов</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Statinov</surname><given-names>P. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Статинов Павел Викторович - начальник отдела медико-физического сопровождения лучевой терапии, ГБУЗ «ПКОД».</p><p>690105, Владивосток, ул. Русская, 59</p></bio><bio xml:lang="en"><p>Pavel V. Statinov - head of the Department of medical and physical support of radiation therapy, GBUZ PKOD.</p><p>59, Russkaya str., Vladivostok, 690105</p></bio><email xlink:type="simple">pvs62@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Приморский краевой онкологический диспансер» (ГБУЗ «ПКОД»); Дальневосточный федеральный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The State Budgetary Healthcare Institution Primorsky Regional Oncological Dispensary; Federal State Autonomous Educational Institution of Higher Education “Far Eastern Federal University”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Приморский краевой онкологический диспансер» (ГБУЗ «ПКОД»)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The State Budgetary Healthcare Institution Primorsky Regional Oncological Dispensary</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>05</day><month>10</month><year>2025</year></pub-date><volume>40</volume><issue>3</issue><fpage>205</fpage><lpage>211</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Петухова Ю.Ю., Стегний К.В., Статинов П.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Петухова Ю.Ю., Стегний К.В., Статинов П.В.</copyright-holder><copyright-holder xml:lang="en">Petukhova Y.Y., Stegny K.V., Statinov P.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sibjcem.ru/jour/article/view/2835">https://www.sibjcem.ru/jour/article/view/2835</self-uri><abstract><sec><title>Введение</title><p>Введение. Прогрессивный рост числа пациентов с онкологическими заболеваниями диктует необходимость повышения качества оказываемой им специализированной медицинской помощи. Лучевая терапия в течение нескольких десятилетий является одним из наиболее значимых и стремительно развивающихся методов лечения злокачественных новообразований. Оборудование, технологии, а также организация проведения радиотерапии в профильных медицинских учреждениях постоянно совершенствуются. Тем не менее, c начала 2024 г. в отделениях радиотерапии ГБУЗ «Приморский краевой онкологический диспансер» сложилась критическая ситуация, связанная с длительным ожиданием госпитализации пациентов, направленных на лучевую терапию в круглосуточный стационар. Анализ превышения сроков госпитализации на лучевую терапию обосновывает необходимость оптимизации существующей системы организации предлучевой подготовки.</p></sec><sec><title>Цель</title><p>Цель: показать организационную и клинико-экономическую эффективность внедрения догоспитальной предлучевой топометрической подготовки в деятельность онкологического диспансера.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследовании использованы статистические данные и нормативные акты, регламентирующие оказание медицинской помощи по профилю «онкология», применен метод клинико-экономического исследования «влияние на бюджет», общенаучные методы систематизации и сравнения.</p></sec><sec><title>Результаты</title><p>Результаты. Представлено научное обоснование клинико-экономической эффективности организации предлучевой топометрической подготовки на догоспитальном этапе. Показана возможность проведения не менее 220 дополнительных госпитализаций в год для оказания высокоэффективной медицинской помощи пациентам с онкологическими заболеваниями без дополнительных финансовых затрат на увеличение коечного фонда. Рассчитан финансовый эквивалент достигнутых преимуществ, составивший более 3 млн 280 тыс. руб. в год.</p></sec><sec><title>Заключение</title><p>Заключение. Внедрение догоспитальной предлучевой подготовки значимо повышает качество оказания специализированной медицинской помощи пациентам с онкологическими заболеваниями, является клинически эффективным и экономически обоснованным. Наиболее ценным аспектом данного усовершенствования является отсутствие необходимости увеличения финансовых вложений в деятельность медицинской организации. Дополнительные преимущества получены за счет изменения очередности процессов топометрии и оформления карты стационарного больного для категории пациентов, не прошедших предлучевую подготовку на догоспитальном этапе.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Due to the increasing number of cancer patients, it is necessary to improve the quality of specialized medical care that is offered to them. Radiation therapy has been one of the most significant and rapidly developing methods of treating malignant neoplasms for several decades. The equipment, technologies, and organization of radiation therapy in specialized medical institutions are constantly being improved. However, since the beginning of 2024, there has been a critical situation in the radiation therapy departments of the Primorsky Regional Cancer Center, which is caused by the long waiting lists for patients who are referred for radiation therapy in a 24-hour hospital. An analysis of the delay in hospitalization for radiation therapy has identified the need to optimize the existing system for organizing pre-radiation preparation.</p></sec><sec><title>Aim</title><p>Aim: To study the organizational and clinical-economic effectiveness of implementing of pre-hospital pre-radiation topometric training in the activities of an oncological dispensary.</p></sec><sec><title>Material and Methods</title><p>Material and Methods. The study used statistical data and regulations governing the provision of medical care in the field of “oncology”, applied the method of clinical and economic research “impact on the budget”, general scientific methods – systematization and comparison.</p></sec><sec><title>Results</title><p>Results. The scientific substantiation of the clinical and economic efficiency of the organization of pre-radiation topometric training at the pre-hospital stage is presented. The possibility of carrying out at least 220 additional hospitalizations per year to provide highly effective medical care to patients with oncological diseases without additional financial costs for increasing the bed capacity has been proven. The financial equivalent of the achieved benefits has been calculated, amounting to more than 3 million 280 thousand rubles per year.</p></sec><sec><title>Conclusion</title><p>Conclusion. The introduction of pre-hospital pre-radiation training significantly improves the quality of specialized medical care for patients with cancer, is clinically effective and economically justified. The most valuable aspect of the organizational improvement being studied is the absence of the need to increase financial investments in the activities of a medical organization. The benefits obtained can be further increased by changing the order of topometry processes and inpatient patient card design for the category of patients who have not completed pre-radiation training at the pre-hospital stage.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>предлучевая подготовка</kwd><kwd>лучевая терапия</kwd><kwd>топометрия</kwd><kwd>разметка</kwd><kwd>ожидание госпитализации</kwd><kwd>качество медицинской помощи</kwd><kwd>догоспитальный этап</kwd><kwd>экономическая эффективность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pre-radiation preparation</kwd><kwd>radiation therapy</kwd><kwd>topometry</kwd><kwd>marking</kwd><kwd>waiting for hospitalization</kwd><kwd>quality of medical care</kwd><kwd>pre-hospital stage</kwd><kwd>economic efficiency</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">исследование выполнено без финансовой поддержки грантов, общественных, некоммерческих, коммерческих организаций и структур</funding-statement><funding-statement xml:lang="en">the work was carried out without the use of grants or financial support from public, non-profit and commercial organizations</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Pathak P.K., Vashisht S.K., Baby S., Jithin P.K., Jain Y., Mahawar R. et al. Commissioning and quality assurance of Halcyon(TM) 2.0 linearaccelerator. Rep. Pract. Oncol. Radiother. 2021;26(3):433–444. https://doi.org/10.5603/RPOR.a2021.0065.</mixed-citation><mixed-citation xml:lang="en">Pathak P.K., Vashisht S.K., Baby S., Jithin P.K., Jain Y., Mahawar R. et al. Commissioning and quality assurance of Halcyon(TM) 2.0 linearaccelerator. Rep. Pract. Oncol. Radiother. 2021;26(3):433–444. https://doi.org/10.5603/RPOR.a2021.0065.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Caravani K., Murry R., Healy B. Characterisation of in-room leakage and scattered radiation for the Varian Halcyonlinearaccelerator. Phys. Eng. Sci. Med. 2022; 45(1):73–81. https://doi.org/10.1007/s13246-021-01084-1.</mixed-citation><mixed-citation xml:lang="en">Caravani K., Murry R., Healy B. Characterisation of in-room leakage and scattered radiation for the Varian Halcyonlinearaccelerator. Phys. Eng. Sci. Med. 2022; 45(1):73–81. https://doi.org/10.1007/s13246-021-01084-1.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Aland T., Jarema T., Trapp J.V., Kairn T. Patient-specific quality assurance on a Varian. Phys. Eng. Sci. Med. 2021;44(2):565–572. https://doi.org/10.1007/s13246-021-00986-4.</mixed-citation><mixed-citation xml:lang="en">Aland T., Jarema T., Trapp J.V., Kairn T. Patient-specific quality assurance on a Varian. Phys. Eng. Sci. Med. 2021;44(2):565–572. https://doi.org/10.1007/s13246-021-00986-4.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gao S., Chetvertkov M.A., Cai B., Dwivedi A., Mihailidis D., Ray X. et al. Beam energy metrics for the acceptance and quality assurance of Halcyon linear accelerator. J. Appl. Clin. Med. Phys. 2021;22(7):121–127. https://doi.org/10.1002/acm2.13281.</mixed-citation><mixed-citation xml:lang="en">Gao S., Chetvertkov M.A., Cai B., Dwivedi A., Mihailidis D., Ray X. et al. Beam energy metrics for the acceptance and quality assurance of Halcyon linear accelerator. J. Appl. Clin. Med. Phys. 2021;22(7):121–127. https://doi.org/10.1002/acm2.13281.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sarkar B., Biswal S.S., Shahid T., Ghosh T., Bhattacharya J., De A. et al. Comparative dosimetric analysis of volumetric modulated arc therapy based craniospinal irradiation plans between Halcyon ring gantry and TrueBeam C-arm linear accelerator. Sci. Rep. 2023;13(1):30–34. https://doi.org/10.1038/s41598-023-30429-x.</mixed-citation><mixed-citation xml:lang="en">Sarkar B., Biswal S.S., Shahid T., Ghosh T., Bhattacharya J., De A. et al. Comparative dosimetric analysis of volumetric modulated arc therapy based craniospinal irradiation plans between Halcyon ring gantry and TrueBeam C-arm linear accelerator. Sci. Rep. 2023;13(1):30–34. https://doi.org/10.1038/s41598-023-30429-x.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Seok J.H., Ahn S.H., Ahn W.S., Choi D.H., Shin S.S., Choi W. et al. Correction to: Comparison of skin dose in IMRT and VMAT with TrueBeam and Halcyonlinearaccelerator for whole breast irradiation. Phys. Eng. Sci. Med. 2024;47(2):45–53. https://doi.org/10.1007/s13246-024-01395-z.</mixed-citation><mixed-citation xml:lang="en">Seok J.H., Ahn S.H., Ahn W.S., Choi D.H., Shin S.S., Choi W. et al. Correction to: Comparison of skin dose in IMRT and VMAT with TrueBeam and Halcyonlinearaccelerator for whole breast irradiation. Phys. Eng. Sci. Med. 2024;47(2):45–53. https://doi.org/10.1007/s13246-024-01395-z.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Toskich B., Lewandowski R.J. Computational modeling of radioembolization: How to calculate infinity. Cardiovasc. Intervent. Radiol. 2021;44(12):2020–2021. https://doi.org/10.1007/s00270-021-02989-w.</mixed-citation><mixed-citation xml:lang="en">Toskich B., Lewandowski R.J. Computational modeling of radioembolization: How to calculate infinity. Cardiovasc. Intervent. Radiol. 2021;44(12):2020–2021. https://doi.org/10.1007/s00270-021-02989-w.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mudge M.C., Green E. Radiotherapy in equine practice. Vet. Clin. North. Am. Equine Pract. 2024;40(3):397–408. https://doi.org/10.1016/j.cveq.2024.07.005.</mixed-citation><mixed-citation xml:lang="en">Mudge M.C., Green E. Radiotherapy in equine practice. Vet. Clin. North. Am. Equine Pract. 2024;40(3):397–408. https://doi.org/10.1016/j.cveq.2024.07.005.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Черных М.В., Крылова Т.А. Методология клинических аудитов отделений лучевой терапии в РФ на основе принципов аудита МАГАТЭ QUATRO. Медицинская радиология и радиационная безопасность. 2024;69(3):68–71. https://doi.org/10.33266/1024-6177-2024-69-3-68-71.</mixed-citation><mixed-citation xml:lang="en">Черных М.В., Крылова Т.А. Методология клинических аудитов отделений лучевой терапии в РФ на основе принципов аудита МАГАТЭ QUATRO. Медицинская радиология и радиационная безопасность. 2024;69(3):68–71. https://doi.org/10.33266/1024-6177-2024-69-3-68-71.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Spampinato S., Tanderup K., Marinovskij E., Axelsen S., Pedersen E.M., Pоtter R. et al. MRI-based contouring of functional sub-structures of the lower urinary tract in gynaecological radiotherapy. Radiother. Oncol. 2020;145:117–124. https://doi.org/10.1016/j.radonc.2019.12.011.</mixed-citation><mixed-citation xml:lang="en">Spampinato S., Tanderup K., Marinovskij E., Axelsen S., Pedersen E.M., Pоtter R. et al. MRI-based contouring of functional sub-structures of the lower urinary tract in gynaecological radiotherapy. Radiother. Oncol. 2020;145:117–124. https://doi.org/10.1016/j.radonc.2019.12.011.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Stuschke M., Pоttgen C. (18) F-FDG PET/CT for target volume contouring in lung cancer radiotherapy. J. Nucl. Med. 2020;61(2):178– 179. https://doi.org/10.2967/jnumed.120.251660.</mixed-citation><mixed-citation xml:lang="en">Stuschke M., Pоttgen C. (18) F-FDG PET/CT for target volume contouring in lung cancer radiotherapy. J. Nucl. Med. 2020;61(2):178– 179. https://doi.org/10.2967/jnumed.120.251660.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Khaw P., Do V., Lim K., Cunninghame J., Dixon J., Vassie J. et al. Radiotherapy quality assurance in the PORTEC-3 (TROG 08.04) trial. Clin. Oncol. (R. Coll. Radiol.). 2022;34(3):198–204. https://doi.org/10.1016/j.clon.2021.11.015.</mixed-citation><mixed-citation xml:lang="en">Khaw P., Do V., Lim K., Cunninghame J., Dixon J., Vassie J. et al. Radiotherapy quality assurance in the PORTEC-3 (TROG 08.04) trial. Clin. Oncol. (R. Coll. Radiol.). 2022;34(3):198–204. https://doi.org/10.1016/j.clon.2021.11.015.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kunzel L.A., Nachbar M., Hagmuller M., Gani C., Boeke S., Wegener D. et al. Clinical evaluation of autonomous, unsupervised planning integrated in MR-guided radiotherapy for prostate cancer. Radiother. Oncol. 2022;168:229–233. https://doi.org/10.1016/j.radonc.2022.01.036.</mixed-citation><mixed-citation xml:lang="en">Kunzel L.A., Nachbar M., Hagmuller M., Gani C., Boeke S., Wegener D. et al. Clinical evaluation of autonomous, unsupervised planning integrated in MR-guided radiotherapy for prostate cancer. Radiother. Oncol. 2022;168:229–233. https://doi.org/10.1016/j.radonc.2022.01.036.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang X., Yan D., Xiao H., Zhong R. Modeling of artificial intelligencebased respiratory motion prediction in MRI-guided radiotherapy: a review. Radiat. Oncol. 2024;19(1):140–146. https://doi.org/10.1186/s13014-024-02532-4.</mixed-citation><mixed-citation xml:lang="en">Zhang X., Yan D., Xiao H., Zhong R. Modeling of artificial intelligencebased respiratory motion prediction in MRI-guided radiotherapy: a review. Radiat. Oncol. 2024;19(1):140–146. https://doi.org/10.1186/s13014-024-02532-4.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann L., Persson G.F., Nygаrd L., Nielsen T.B., Borrisova S., Gaard-Petersen F. et al. Thorough design and pre-trial quality assurance (QA) decrease dosimetric impact of delineation and dose planning variability in the STRICTLUNG and STARLUNG trials for stereotactic body radiotherapy (SBRT) of central and ultra-central lung tumours. Radiother. Oncol. 2022;171:53–61. https://doi.org/10.1016/j.radonc.2022.04.005.</mixed-citation><mixed-citation xml:lang="en">Hoffmann L., Persson G.F., Nygаrd L., Nielsen T.B., Borrisova S., Gaard-Petersen F. et al. Thorough design and pre-trial quality assurance (QA) decrease dosimetric impact of delineation and dose planning variability in the STRICTLUNG and STARLUNG trials for stereotactic body radiotherapy (SBRT) of central and ultra-central lung tumours. Radiother. Oncol. 2022;171:53–61. https://doi.org/10.1016/j.radonc.2022.04.005.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Nikitas J., Smith L.M., Gao Y., Ma T.M., Sachdeva A., Yoon S.M. et al. The role of adaptive planning in margin-reduced, MRI-guided stereotactic body radiotherapy to the prostate bed following radical prostatectomy: Post-hoc analysis of a phase II clinical trial. Radiother. Oncol. 2023;183:119–121. https://doi.org/10.1016/j.radonc.2023.109631.</mixed-citation><mixed-citation xml:lang="en">Nikitas J., Smith L.M., Gao Y., Ma T.M., Sachdeva A., Yoon S.M. et al. The role of adaptive planning in margin-reduced, MRI-guided stereotactic body radiotherapy to the prostate bed following radical prostatectomy: Post-hoc analysis of a phase II clinical trial. Radiother. Oncol. 2023;183:119–121. https://doi.org/10.1016/j.radonc.2023.109631.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Yagihashi T., Inoue K., Nagata H., Yamanaka M., Yamano A., Suzuki S. et al. Effectiveness of robust optimization against geometric uncertainties in TomoHelical planning for prostate cancer. J. Appl. Clin. Med. Phys. 2023;24(4):83–81. https://doi.org/10.1002/acm2.13881.</mixed-citation><mixed-citation xml:lang="en">Yagihashi T., Inoue K., Nagata H., Yamanaka M., Yamano A., Suzuki S. et al. Effectiveness of robust optimization against geometric uncertainties in TomoHelical planning for prostate cancer. J. Appl. Clin. Med. Phys. 2023;24(4):83–81. https://doi.org/10.1002/acm2.13881.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Frederick A., Roumeliotis M., Grendarova P., Quirk S. Performance of a knowledge-based planning model for optimizing intensity-modulated radiotherapy plans for partial breast irradiation. J. Appl. Clin. Med. Phys. 2022;23(3):135–136. https://doi.org/10.1002/acm2.13506.</mixed-citation><mixed-citation xml:lang="en">Frederick A., Roumeliotis M., Grendarova P., Quirk S. Performance of a knowledge-based planning model for optimizing intensity-modulated radiotherapy plans for partial breast irradiation. J. Appl. Clin. Med. Phys. 2022;23(3):135–136. https://doi.org/10.1002/acm2.13506.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cilla S., Macchia G., Romano C., Morabito V.E., Boccardi M., Picardi V. et al. Challenges in lung and heart avoidance for postmastectomy breast cancer radiotherapy: Is automated planning the answer? Med. Dosim. 2021;46(3):295–303. https://doi.org/10.1016/j.meddos.2021.03.002.</mixed-citation><mixed-citation xml:lang="en">Cilla S., Macchia G., Romano C., Morabito V.E., Boccardi M., Picardi V. et al. Challenges in lung and heart avoidance for postmastectomy breast cancer radiotherapy: Is automated planning the answer? Med. Dosim. 2021;46(3):295–303. https://doi.org/10.1016/j.meddos.2021.03.002.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
