cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2017-32-3-7-13cardiotomsk-319Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESКАННАБИНОИДЕРГИЧЕСКАЯ РЕГУЛЯЦИЯ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ СЕРДЦА (ЧАСТЬ I)CANNABINOIDERGIC REGULATION OF FUNCTIONAL STATE OF HEART (PART I)КрылатовА. В.KrylatovA. V.

канд. мед. наук, лаборант-исследователь лаборатории экспериментальной кардиологии

Maslov@cardio-tomsk.ruСеребровВ. Ю.SerebrovV. Yu.

докт. мед. наук, профессор кафедры биохимии и молекулярной биологии с курсом клинической лабораторной диагностики Сибирского государственного медицинского университета, профессор кафедры биотехнологии и органической химии Института высоких технологий Национального исследовательского Томского политехнического университета

serebrov@ssmu.ruВаизоваО. Е.VaizovaO. E.

докт. мед. наук, профессор кафедры фармакологии

vaizova@mail.ruДьяковаЕ. Ю.DyakovaE. Yu.

докт. мед. наук, профессор кафедры спортивно-оздоровительного туризма, спортивной физиологии и медицины факультета физической культуры

adyakova@yandex.ruНаучно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наук, ТомскРоссияCardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, TomskRussian FederationНациональный исследовательский Томский политехнический университет, Томск; Сибирский государственный медицинский университет, ТомскРоссияNational Research Tomsk Polytechnic University, Tomsk; Siberian State Medical University, TomskRussian FederationСибирский государственный медицинский университет, ТомскРоссияSiberian State Medical University, TomskRussian FederationНациональный исследовательский Томский государственный университет, ТомскРоссияNational Research Tomsk State University, TomskRussian Federation201723112017323713Copyright © Крылатов А.В., Серебров В.Ю., Ваизова О.Е., Дьякова Е.Ю., 20172017Крылатов А.В., Серебров В.Ю., Ваизова О.Е., Дьякова Е.Ю.Krylatov A.V., Serebrov V.Y., Vaizova O.E., Dyakova E.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/319

Установлено, что у наркотизированных животных каннабиноиды вызывают продолжительную гипотензию и брадикардию, которые являются следствием стимуляции СВ1-рецепторов. Эндогенные каннабиноиды не участвуют в регуляции частоты сердечных сокращений и артериального давления у интактных животных. Исследования, выполненные на больных ишемической болезнью сердца, показали, что марихуана может провоцировать приступ стенокардии. Установлено, что каннабиноиды вызывают продолжительную гипотензию и брадикардию, которым могут предшествовать транзиторная тахикардия и гипертензия, связанные с активацией ваниллоидных TRPV1 ре-цепторов. Продолжительная гипотензия — результат прямого действия каннабиноидов на артерии.

 

It was found that cannabinoids in anesthetized animals cause prolonged hypotension and bradycardia, which are the result of the stimulation of the CB1 receptor. The endogenous cannabinoids are not involved in the regulation of heart rate and blood pressure in intact animals. Studies carried out in patients with coronary heart disease have shown that marijuana can cause angina. It is established that cannabinoids induce prolonged hypotension and bradycardia, which may be preceded by transient tachycardia and hypertension associated with activation of the vanilloid TRPV1 receptor. Prolonged hypotension is a result of direct action of cannabinoids on the arteries.

 

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The authors declare that there are no conflicts of interest present.