cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2017-32-4-7-10cardiotomsk-358Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESКАННАБИНОИДЕРГИЧЕСКАЯ РЕГУЛЯЦИЯ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ СЕРДЦА (ЧАСТЬ II)CANNABINOIDERGIC REGULATION OF FUNCTIONAL STATE OF HEART (PART II)КрылатовА. В.KrylatovA. V.

канд. мед. наук, лаборант-исследователь лаборатории экспериментальной кардиологии

Cand. Sci. (Med.), Laboratory Assistant Researcher, Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences

Maslov@cardio-tomsk.ruСеребровВ. Ю.SerebrovV. Yu.

д-р мед. наук, профессор кафедры биохимии и молекулярной биологии с курсом клинической лабораторной диагностики Сибирского государственного медицинского университета Министерства здравоохранения Российской Федерации, профессор кафедры биотехнологии и органической химии Института высоких технологий Национального исследовательского Томского политехнического университета

Dr. Sci. (Med.), Professor of the Department of Biochemistry and Molecular Biology with a Course in Clinical Laboratory Diagnostics, Siberian State Medical University; Professor of the Department of Biotechnology and Organic Chemistry, Institute of High Technologies, National Research Tomsk Polytechnic University

serebrov@ssmu.ruВаизоваО. Е.VaizovaO. E.

д-р мед. наук, профессор кафедры фармакологии Сибирского государственного медицинского университета Министерства здравоохранения Российской Федерации

Dr. Sci. (Med.), Professor of the Department of Pharmacology, Siberian State Medical University

vaizova@mail.ruДьяковаЕ. Ю.DyakovaE. Yu.

д-р мед. наук, профессор кафедры спортивно-оздоровительного туризма, спортивной физиологии и медицины факультета физической культуры

Dr. Sci. (Med.), Professor of the Department of Sport and Health Tourism, Sports Physiology and Medicine, Faculty of Physical Education, National Research Tomsk State University

adyakova@yandex.ruНаучно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наук, ТомскРоссияCardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, TomskRussian FederationНациональный исследовательский Томский политехнический университет, Томск; Сибирский государственный медицинский университет Министерства здравоохранения Российской Федерации, ТомскРоссияNational Research Tomsk Polytechnic University, Tomsk; Siberian State Medical University, TomskRussian FederationСибирский государственный медицинский университет Министерства здравоохранения Российской Федерации, ТомскРоссияSiberian State Medical University, TomskRussian FederationНациональный исследовательский Томский государственный университет, ТомскРоссияNational Research Tomsk State University, TomskRussian Federation201715022018324710Copyright © Крылатов А.В., Серебров В.Ю., Ваизова О.Е., Дьякова Е.Ю., 20182018Крылатов А.В., Серебров В.Ю., Ваизова О.Е., Дьякова Е.Ю.Krylatov A.V., Serebrov V.Y., Vaizova O.E., Dyakova E.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/358

Экспериментальные исследования показали, что каннабиноиды вызывают гипотензию и брадикардию, которые являются следствием стимуляции каннабиноидных СВ1-рецепторов. Каннабиноид-индуцированная брадикардия является результатом симпатолитического и ваготонического действия каннабиноидов.

 

 

 

 

Experimental studies showed that cannabinoids evoke hypotension and bradycardia, which are the result of the stimulation of the cannabinoid CB1 receptor. Cannabinoid-induced bradycardia is the result of sympatholytic and vagotonic action of cannabinoids.

 

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The authors declare that there are no conflicts of interest present.