cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2014-29-1-17-24cardiotomsk-53Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРадионуклидная диагностика нестабильных атеросклеротических бляшекThe radionuclide diagnosis of the vulnerable atherosclerotic plaquesПавловаДиана АлександровнаPavlovaD. A.pavlova.diana.alm@gmail.comЕфимоваНаталия ЮрьевнаEfimovaN. Yu.efimova@cardio-tomsk.ruРыжковаДарья ВикторовнаRyzhkovaD. V.d_ryjkova@mail.ruФГБУ “Федеральный медицинский исследовательский центр им. В.А. Алмазова” Минздрава РоссииРоссияFederal Medical Research Centre n.a. AlmazovRussian FederationФГБУ "НИИ кардиологии" СО РАМН; ФГБОУ ВПО "Национальный исследовательский Томский политехнический университет"РоссияFederal State Budgetary Institution "Research Institute for Cardiology" of Siberian Branch under the Russian Academy of Medical Sciences; Tomsk Polytechnic UniversityRussian FederationФГБУ "Федеральный медицинский исследовательский центр им. В.А. Алмазова" Минздрава РоссииРоссияFederal Medical Research Centre n.a. AlmazovRussian Federation2014060920162911724Copyright © Павлова Д.А., Ефимова Н.Ю., Рыжкова Д.В., 20162016Павлова Д.А., Ефимова Н.Ю., Рыжкова Д.В.Pavlova D.A., Efimova N.Y., Ryzhkova D.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/53

В работе обобщены литературные данные о радионуклидной диагностике атеросклеротического поражения сосудов. Особое внимание уделено характеристике гамма- и позитрон-излучающих радиофармацевтических препаратов, которые используют для молекулярной визуализации нестабильных бляшек.

The article summarizes the published data on the radionuclide diagnosis of atherosclerotic vascular lesions. A special attention is given to the characteristics of gamma and positron emitting tracers, which are used for molecular imaging of unstable plaques.

атеросклерознестабильная бляшкарадионуклидная диагностикапозитронная эмиссионная томографияatherosclerosisvulnerable plaqueradionuclide diagnosispositron emission tomographyReferencesВрублевский А.В., Бошенко А.В., Ицкович И.Э. и соавт. Современные методы визуализации коронарных артерий в диагностике коронарного атеросклероза // Кардиология. - 2007. - Т. 47, № 7. - С. 83-93.Врублевский А.В., Бошенко А.В., Ицкович И.Э. и соавт. Современные методы визуализации коронарных артерий в диагностике коронарного атеросклероза // Кардиология. - 2007. - Т. 47, № 7. - С. 83-93.Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза // Рекомендации ВНОК. - М.: 2005. - С. 9-14.Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза // Рекомендации ВНОК. - М.: 2005. - С. 9-14.Оганов Р.Г. Концепция факторов риска как основа профилактики сердечно-сосудистых заболеваний // Врач. - 2001. - № 7. - С. 3-6.Оганов Р.Г. Концепция факторов риска как основа профилактики сердечно-сосудистых заболеваний // Врач. - 2001. - № 7. - С. 3-6.Alexopoulos N., Raggi P. Calcification in atherosclerosis // Nat. Rev. Cardiol. - 2009. - Vol. 6. - P. 681-688.Alexopoulos N., Raggi P. Calcification in atherosclerosis // Nat. Rev. Cardiol. - 2009. - Vol. 6. - P. 681-688.Annovazzi A., Bonanno E., Arca M. et al. 99mTc-interleukin-2 scintigraphy for the in vivo imaging of vulnerable atherosclerotic plaques // Eur. J. Nucl. Med. Mol. Imaging. - 2006. - Vol. 33. -P. 117-126.Annovazzi A., Bonanno E., Arca M. et al. 99mTc-interleukin-2 scintigraphy for the in vivo imaging of vulnerable atherosclerotic plaques // Eur. J. Nucl. Med. Mol. Imaging. - 2006. - Vol. 33. -P. 117-126.Antonov A.S., Kolodgie F.D., Munn D.H. et al. Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis // Am. J. Pathol. - 2004. - Vol. 165. - P. 247-258.Antonov A.S., Kolodgie F.D., Munn D.H. et al. Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis // Am. J. Pathol. - 2004. - Vol. 165. - P. 247-258.Ayala-Lopez W., Xia W., Varghese B. et al. Imaging of atherosclerosis in apoliprotein e knockout mice: targeting of a folate-conjugated radiopharmaceutical to activated macrophages // J. Nucl. Med. - 2010. - Vol. 51. - P. 768-774.Ayala-Lopez W., Xia W., Varghese B. et al. Imaging of atherosclerosis in apoliprotein e knockout mice: targeting of a folate-conjugated radiopharmaceutical to activated macrophages // J. Nucl. Med. - 2010. - Vol. 51. - P. 768-774.Ben-Haim S., Kupzov E., Tamir A. et al. Evaluation of 18F-FDG uptake and arterial wall calcifications using 18F-FDG PET/CT // J. Nucl. Med. - 2004. - Vol. 45. - P. 1816-1821.Ben-Haim S., Kupzov E., Tamir A. et al. Evaluation of 18F-FDG uptake and arterial wall calcifications using 18F-FDG PET/CT // J. Nucl. Med. - 2004. - Vol. 45. - P. 1816-1821.Bozoky Z., Balogh L., Mathe D. et al. Preparation and investigation of 99m technetium-labeled low-density lipoproteins in rabbits with experimentally induced hypercholesterolemia // Eur. Biophys. J. - 2004. - Vol. 33. -P. 140-145.Bozoky Z., Balogh L., Mathe D. et al. Preparation and investigation of 99m technetium-labeled low-density lipoproteins in rabbits with experimentally induced hypercholesterolemia // Eur. Biophys. J. - 2004. - Vol. 33. -P. 140-145.Canat X., Guillaumont A., Bouaboula M. et al. Peripheral benzodiazepine receptor modulation with phagocyte differentiation // Biochem. Pharmacol. - 1993. - Vol. 46. -P. 551-554.Canat X., Guillaumont A., Bouaboula M. et al. Peripheral benzodiazepine receptor modulation with phagocyte differentiation // Biochem. Pharmacol. - 1993. - Vol. 46. -P. 551-554.Chiu J.J., Chien S. Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives // Physiol. Rev. - 2011. - Vol. 91. - P. 327-387.Chiu J.J., Chien S. Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives // Physiol. Rev. - 2011. - Vol. 91. - P. 327-387.Dalm V.A., van Hagen P.M., van Koetsveld P.M. et al. Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells // Am. J. Physiol. Endocrinol. Metab. - 2003. - Vol. 285. - E344-E353.Dalm V.A., van Hagen P.M., van Koetsveld P.M. et al. Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells // Am. J. Physiol. Endocrinol. Metab. - 2003. - Vol. 285. - E344-E353.Davies J.R., Rudd J.H., Fryer T.D. et al. Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and highresolution magnetic resonance imaging // Stroke. - 2005. -Vol. 36. - P. 2642-2647.Davies J.R., Rudd J.H., Fryer T.D. et al. Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and highresolution magnetic resonance imaging // Stroke. - 2005. -Vol. 36. - P. 2642-2647.Davies M.J., Richardson P.D., Woolf N. et al. Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content // Br. Heart J. - 1993. - Vol. 69. - P. 377-381.Davies M.J., Richardson P.D., Woolf N. et al. Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content // Br. Heart J. - 1993. - Vol. 69. - P. 377-381.Falk E., Shah P.K., Fuster V. Coronary plaque disruption // Circulation. - 1995. - Vol. 92. - P. 657-671.Falk E., Shah P.K., Fuster V. Coronary plaque disruption // Circulation. - 1995. - Vol. 92. - P. 657-671.Falk E. Pathogenesis of atherosclerosis // J. Am. Coll. Cardiol. - 2006. - Vol. 47. - P. 7-12.Falk E. Pathogenesis of atherosclerosis // J. Am. Coll. Cardiol. - 2006. - Vol. 47. - P. 7-12.Fayad Z.A., Mani V., Woodward M. et al. Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial // Lancet. - 2011. - Vol. 378. - P. 1547-1559.Fayad Z.A., Mani V., Woodward M. et al. Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial // Lancet. - 2011. - Vol. 378. - P. 1547-1559.Frayn K. The glucose-fatty acid cycle: a physiological perspective // Biochem. Soc. Trans. - 2003. - Vol. 31. - P. 1115-1119.Frayn K. The glucose-fatty acid cycle: a physiological perspective // Biochem. Soc. Trans. - 2003. - Vol. 31. - P. 1115-1119.Fujimoto S., Hartung D., Ohshima S. et al. Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy // J. Am. Coll. Cardiol. - 2008. - Vol. 52. - P. 1847-1857.Fujimoto S., Hartung D., Ohshima S. et al. Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy // J. Am. Coll. Cardiol. - 2008. - Vol. 52. - P. 1847-1857.Gaemperli O., Shalhoub J., Owen D.R. et al. Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography // Eur. Heart. J. - 2012. - Vol. 33. - P. 1902-1910.Gaemperli O., Shalhoub J., Owen D.R. et al. Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography // Eur. Heart. J. - 2012. - Vol. 33. - P. 1902-1910.George R.T. 18F-sodium fluoride positron emission tomography: an in vivo window into coronary atherosclerotic plaque biology // J. Am. Coll. Cardiol. - 2012. - Vol. 59. - P. 1549-1550.George R.T. 18F-sodium fluoride positron emission tomography: an in vivo window into coronary atherosclerotic plaque biology // J. Am. Coll. Cardiol. - 2012. - Vol. 59. - P. 1549-1550.Greenland P., LaBree L., Azen S.P. et al. Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals // JAMA. - 2004. - Vol. 291. - P. 210215.Greenland P., LaBree L., Azen S.P. et al. Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals // JAMA. - 2004. - Vol. 291. - P. 210215.Haider. N., Hartung. D., Fujimoto. S. et al. Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis // J. Nucl. Cardiol. - 2009. - Vol. 16. - P. 753-762.Haider. N., Hartung. D., Fujimoto. S. et al. Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis // J. Nucl. Cardiol. - 2009. - Vol. 16. - P. 753-762.Hartung D., Petrov A., Haider N. et al. Radiolabeled Monocyte Chemotactic Protein 1 for the detection of inflammation in experimental atherosclerosis // J. Nucl. Med. - 2007. - Vol. 48. - P. 1816-1821.Hartung D., Petrov A., Haider N. et al. Radiolabeled Monocyte Chemotactic Protein 1 for the detection of inflammation in experimental atherosclerosis // J. Nucl. Med. - 2007. - Vol. 48. - P. 1816-1821.Hartung D., Sarai M., Petrov A. et al. Resolution of apoptosis in atherosclerotic plaque by dietary modification and statin therapy // J. Nucl. Med. - 2005. - Vol. 46. - P. 2051-2056.Hartung D., Sarai M., Petrov A. et al. Resolution of apoptosis in atherosclerotic plaque by dietary modification and statin therapy // J. Nucl. Med. - 2005. - Vol. 46. - P. 2051-2056.Hoshiga M., Alpers C.E., Smith L.L. et al. Alpha-v beta-3 integrin expression in normal and atherosclerotic artery // Circ Res. - 1995. - Vol. 77. - P. 1129-1135.Hoshiga M., Alpers C.E., Smith L.L. et al. Alpha-v beta-3 integrin expression in normal and atherosclerotic artery // Circ Res. - 1995. - Vol. 77. - P. 1129-1135.Ishino S., Kuge Y., Takai N. et al. 99mTc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits // Eur. J. Nucl. Med. Mol. Imaging. - 2007. - Vol. 34. - P. 889-890.Ishino S., Kuge Y., Takai N. et al. 99mTc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits // Eur. J. Nucl. Med. Mol. Imaging. - 2007. - Vol. 34. - P. 889-890.Isobe S., Tsimikas S., Zhou J. et al. Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5 // J. Nucl. Med. - 2006. - Vol. 47. - P. 1497-1505.Isobe S., Tsimikas S., Zhou J. et al. Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5 // J. Nucl. Med. - 2006. - Vol. 47. - P. 1497-1505.Iuliano L., Signore A., Vallabajosula S. et al. Preparation and biodistribution of 99m technetium labelled oxidized LDL in man // Atherosclerosis. - 1996. - Vol. 126. - P. 131-141.Iuliano L., Signore A., Vallabajosula S. et al. Preparation and biodistribution of 99m technetium labelled oxidized LDL in man // Atherosclerosis. - 1996. - Vol. 126. - P. 131-141.Johnson L.L., Schofield L., Donahay T. et al. 99mTc-annexin V imaging for in vivo detection of atherosclerotic lesions in porcine coronary arteries // J. Nucl. Med. - 2005. - Vol. 46. -P. 1186-1193.Johnson L.L., Schofield L., Donahay T. et al. 99mTc-annexin V imaging for in vivo detection of atherosclerotic lesions in porcine coronary arteries // J. Nucl. Med. - 2005. - Vol. 46. -P. 1186-1193.Kato K., Schober O., Ikeda M. et al. Evaluation and comparison of 11C-choline uptake and calcification in aortic and common carotid arterial walls with combined PET/CT // Eur. J. Nucl. Med. Mol. Imaging. - 2009. - Vol. 36. - P. 1622-1628.Kato K., Schober O., Ikeda M. et al. Evaluation and comparison of 11C-choline uptake and calcification in aortic and common carotid arterial walls with combined PET/CT // Eur. J. Nucl. Med. Mol. Imaging. - 2009. - Vol. 36. - P. 1622-1628.Kietselaer B.L., Reutelingsperger C.P., Heidendal G.A. et al. Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis // N. Engl. J. Med. - 2004. - Vol. 350. - P. 14721473.Kietselaer B.L., Reutelingsperger C.P., Heidendal G.A. et al. Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis // N. Engl. J. Med. - 2004. - Vol. 350. - P. 14721473.Kolodgie F.D., Petrov A., Virmani R. et al. Targeting of apoptotic macrophages and experimental atheroma with radiolabeled annexin V: a technique with potential for noninvasive imaging of vulnerable plaque // Circulation. - 2003. - Vol. 108. - P. 3134-3139.Kolodgie F.D., Petrov A., Virmani R. et al. Targeting of apoptotic macrophages and experimental atheroma with radiolabeled annexin V: a technique with potential for noninvasive imaging of vulnerable plaque // Circulation. - 2003. - Vol. 108. - P. 3134-3139.Koopman G., Reutelingsperger C.P., Kuijten G.A. et al. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis // Blood. - 1994. -Vol. 84. - P. 1415-1420.Koopman G., Reutelingsperger C.P., Kuijten G.A. et al. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis // Blood. - 1994. -Vol. 84. - P. 1415-1420.Kuge Y., Takai N., Ogawa Y. et al. Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques // Eur. J. Nucl. Med. Mol. Imaging. - 2010. - Vol. 37. - P. 20932104.Kuge Y., Takai N., Ogawa Y. et al. Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques // Eur. J. Nucl. Med. Mol. Imaging. - 2010. - Vol. 37. - P. 20932104.Kwee R.M., Truijman M.T., Mess W.H. et al. Potential of integrated [18F] fluorodeoxyglucose positron-emission tomography/CT in identifying vulnerable carotid plaques // AJNR Am. J. Neuroradiol. - 2011. - Vol. 32. - P. 950-954.Kwee R.M., Truijman M.T., Mess W.H. et al. Potential of integrated [18F] fluorodeoxyglucose positron-emission tomography/CT in identifying vulnerable carotid plaques // AJNR Am. J. Neuroradiol. - 2011. - Vol. 32. - P. 950-954.Kzhyshkowska J., Neyen C., Gordon S. Role of macrophage scavenger receptors in atherosclerosis // Immunobiology. -2012. - Vol. 217. - P. 492-502.Kzhyshkowska J., Neyen C., Gordon S. Role of macrophage scavenger receptors in atherosclerosis // Immunobiology. -2012. - Vol. 217. - P. 492-502.Laitinen I., Marjamaki P., Haaparanta M. et al. Uptake of [C-11]PK11195, a marker of inflammatory cells, into atherosclerotic plaques in mice // Basic Clin. Pharmacol. Toxicol. - 2008. -Vol. 102, Is. Sup. S1. - P. 48-49.Laitinen I., Marjamaki P., Haaparanta M. et al. Uptake of [C-11]PK11195, a marker of inflammatory cells, into atherosclerotic plaques in mice // Basic Clin. Pharmacol. Toxicol. - 2008. -Vol. 102, Is. Sup. S1. - P. 48-49.Laitinen I., Saraste A., Weidl E. et al. Evaluation of alpha(v)beta(3) integrin-targeted positron emission tomography tracer F-18-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice // Circ. Cardiovasc. Imaging. - 2009. -Vol. 2. - P. 331-338.Laitinen I., Saraste A., Weidl E. et al. Evaluation of alpha(v)beta(3) integrin-targeted positron emission tomography tracer F-18-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice // Circ. Cardiovasc. Imaging. - 2009. -Vol. 2. - P. 331-338.Li X., Samnick S., Lapa C. et al. 68Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with18F-FDG, calcium burden and risk factors // EJNMMI Research. -2012. - Vol. 2. - P. 52.Li X., Samnick S., Lapa C. et al. 68Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with18F-FDG, calcium burden and risk factors // EJNMMI Research. -2012. - Vol. 2. - P. 52.Libby P. Inflammation in atherosclerosis // Nature. - 2002. -Vol. 420. - P. 868-874.Libby P. Inflammation in atherosclerosis // Nature. - 2002. -Vol. 420. - P. 868-874.Matter C.M., Wyss M.T., Meier P. et al. 18F-choline images murine atherosclerotic plaques ex vivo // Arterioscler. Thromb. Vasc. Biol. - 2006. - Vol. 26. - P. 584-589.Matter C.M., Wyss M.T., Meier P. et al. 18F-choline images murine atherosclerotic plaques ex vivo // Arterioscler. Thromb. Vasc. Biol. - 2006. - Vol. 26. - P. 584-589.Nahrendorf M., Keliher E., Panizzi P. et al. 18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis // J. Am. Coll. Cardiol. Cardiovasc. Imaging. - 2009. - Vol. 2. - P. 1213-1222.Nahrendorf M., Keliher E., Panizzi P. et al. 18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis // J. Am. Coll. Cardiol. Cardiovasc. Imaging. - 2009. - Vol. 2. - P. 1213-1222.O’Rourke R.A., Brundage B.H., Froelicher V.F. et al. American College of Cardiology/American Heart Association Expert Consensus Document on electron-beam computed tomography for the diagnosis and prognosis of coronary artery disease // J. Am. Coll. Cardiol. - 2000. - Vol. 36. - P. 326-340.O’Rourke R.A., Brundage B.H., Froelicher V.F. et al. American College of Cardiology/American Heart Association Expert Consensus Document on electron-beam computed tomography for the diagnosis and prognosis of coronary artery disease // J. Am. Coll. Cardiol. - 2000. - Vol. 36. - P. 326-340.Ogawa M., Ishino S., Mukai T. et al. 18F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study // J. Nucl. Med. - 2004. - Vol. 45. - P. 1245-1250.Ogawa M., Ishino S., Mukai T. et al. 18F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study // J. Nucl. Med. - 2004. - Vol. 45. - P. 1245-1250.Ohtsuki K., Hayase M., Akashi K. et al. Detection of monocyte chemoattractant protein-1 receptor expression in experimental atherosclerotic lesions: an autoradiographic study // Circulation. - 2001. - Vol. 104. - P. 203-208.Ohtsuki K., Hayase M., Akashi K. et al. Detection of monocyte chemoattractant protein-1 receptor expression in experimental atherosclerotic lesions: an autoradiographic study // Circulation. - 2001. - Vol. 104. - P. 203-208.Opalinska M., Stompor T., Pach D. et al. Imaging of inflamed carotid artery atherosclerotic plaques with the use of (99m)Tc-HYNIC-IL-2 scintigraphy in end-stage renal disease patients // Eur. J. Nucl. Med. Mol. Imaging. - 2012. - Vol. 39. - P. 673-682.Opalinska M., Stompor T., Pach D. et al. Imaging of inflamed carotid artery atherosclerotic plaques with the use of (99m)Tc-HYNIC-IL-2 scintigraphy in end-stage renal disease patients // Eur. J. Nucl. Med. Mol. Imaging. - 2012. - Vol. 39. - P. 673-682.Razavian M., Tavakoli S., Zhang J. et al. Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation // J. Nucl. Med. - 2011. - Vol. 52. - P. 1795-1802.Razavian M., Tavakoli S., Zhang J. et al. Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation // J. Nucl. Med. - 2011. - Vol. 52. - P. 1795-1802.Roger V.L., Go A.S., Lloyd-Jones D.M. et al. Heart disease and stroke statistics-2011 update: a report from the American Heart Association // Circulation. - 2011. - Vol. 123. - e18-e209.Roger V.L., Go A.S., Lloyd-Jones D.M. et al. Heart disease and stroke statistics-2011 update: a report from the American Heart Association // Circulation. - 2011. - Vol. 123. - e18-e209.Rogers I.S., Nasir K., Figueroa A.L. et al. Feasibility of FDG imaging of the coronary arteries: comparison between acute coronary syndrome and stable angina // J. Am. Coll. Cardiol. Img. - 2010. - Vol. 3. - P. 388-397.Rogers I.S., Nasir K., Figueroa A.L. et al. Feasibility of FDG imaging of the coronary arteries: comparison between acute coronary syndrome and stable angina // J. Am. Coll. Cardiol. Img. - 2010. - Vol. 3. - P. 388-397.Rominger A., Saam T., Wolpers S. et al. 18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease // J. Nucl. Med. - 2009. - Vol. 50. - P. 1611-1620.Rominger A., Saam T., Wolpers S. et al. 18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease // J. Nucl. Med. - 2009. - Vol. 50. - P. 1611-1620.Rudd J.H., Warburton E.A., Fryer T.D. et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography // Circulation. - 2002. - Vol. 105. - P. 2708-2711.Rudd J.H., Warburton E.A., Fryer T.D. et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography // Circulation. - 2002. - Vol. 105. - P. 2708-2711.Saam T., Rominger A., Wolpers S. et al. Association of inflammation of the left anterior descending coronary artery with cardiovascular risk factors, plaque burden and pericardial fat volume: a PET/CT study // Eur. J. Nucl. Med. Mol. Imaging. - 2010. - Vol. 37. - P. 1203-1212.Saam T., Rominger A., Wolpers S. et al. Association of inflammation of the left anterior descending coronary artery with cardiovascular risk factors, plaque burden and pericardial fat volume: a PET/CT study // Eur. J. Nucl. Med. Mol. Imaging. - 2010. - Vol. 37. - P. 1203-1212.Sarai M., Hartung D., Petrov A. et al. Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging // J. Am. Coll. Cardiol. - 2007. - Vol. 50. - P. 23052312.Sarai M., Hartung D., Petrov A. et al. Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging // J. Am. Coll. Cardiol. - 2007. - Vol. 50. - P. 23052312.Sheikine Y., Akram K. FDG-PET imaging of atherosclerosis: Do we know what we see? // Atherosclerosis. - 2010. - Vol. 211. -P. 371-380.Sheikine Y., Akram K. FDG-PET imaging of atherosclerosis: Do we know what we see? // Atherosclerosis. - 2010. - Vol. 211. -P. 371-380.Tabas I. Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stress // Antioxid. Redox. Signal. - 2009. - Vol. 11. - P. 2333-2339.Tabas I. Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stress // Antioxid. Redox. Signal. - 2009. - Vol. 11. - P. 2333-2339.Tahara N., Kai H., Ishibashi M. et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography // J. Am. Coll. Cardiol. - 2006. - Vol. 48. - P. 1825-1831.Tahara N., Kai H., Ishibashi M. et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography // J. Am. Coll. Cardiol. - 2006. - Vol. 48. - P. 1825-1831.Tawakol А., Migrino R.Q., Bashian G.G. et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients // J. Am. Coll. Cardiol. - 2006. - Vol. 48. - P. 1818-1824.Tawakol А., Migrino R.Q., Bashian G.G. et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients // J. Am. Coll. Cardiol. - 2006. - Vol. 48. - P. 1818-1824.Tekabe Y., Li Q., Luma J. et al. Noninvasive monitoring the biology of atherosclerotic plaque development with radiolabeled annexin V and matrix metalloproteinase inhibitor in spontaneous atherosclerotic mice // J. Nucl. Cardiol. - 2010. -Vol. 17. - P. 1073-1081.Tekabe Y., Li Q., Luma J. et al. Noninvasive monitoring the biology of atherosclerotic plaque development with radiolabeled annexin V and matrix metalloproteinase inhibitor in spontaneous atherosclerotic mice // J. Nucl. Cardiol. - 2010. -Vol. 17. - P. 1073-1081.Teras M., Kokki T., Durand-Schaefer N. et al. Dual-gated cardiac PET-clinical feasibility study // Eur. J. Nucl. Med. Mol. Imaging. - 2010. - Vol. 37. - P. 505-516.Teras M., Kokki T., Durand-Schaefer N. et al. Dual-gated cardiac PET-clinical feasibility study // Eur. J. Nucl. Med. Mol. Imaging. - 2010. - Vol. 37. - P. 505-516.Vallabhajosula S., Fuster V. Atherosclerosis: imaging techniques and the evolving role of nuclear medicine // J. Nucl. Med. -1997. - Vol. 38, № 11. - P. 1788-1796.Vallabhajosula S., Fuster V. Atherosclerosis: imaging techniques and the evolving role of nuclear medicine // J. Nucl. Med. -1997. - Vol. 38, № 11. - P. 1788-1796.Vallabhajosula S., Machac J., Knesaurek K. Imaging atherosclerotic macrophage density by positron emission tomography using F-18-fluorodeoxyglucose (FDG) // J. Nucl. Med. - 1996. - Vol. 37. - P. 38.Vallabhajosula S., Machac J., Knesaurek K. Imaging atherosclerotic macrophage density by positron emission tomography using F-18-fluorodeoxyglucose (FDG) // J. Nucl. Med. - 1996. - Vol. 37. - P. 38.Wildgruber M., Swirski F.K., Zernecke A. Molecular imaging of inflammation in atherosclerosis // Theranostics. - 2013. - Vol. 3. - P. 865-884.Wildgruber M., Swirski F.K., Zernecke A. Molecular imaging of inflammation in atherosclerosis // Theranostics. - 2013. - Vol. 3. - P. 865-884.Williams G., Kolodny G.M. Suppression of myocardial 18F-FDG uptake by preparing patients with a high-fat, low-carbohydrate diet // Am. J. Roentgenol. - 2008. - Vol. 190. - W151-156.Williams G., Kolodny G.M. Suppression of myocardial 18F-FDG uptake by preparing patients with a high-fat, low-carbohydrate diet // Am. J. Roentgenol. - 2008. - Vol. 190. - W151-156.Wykrzykowska J., Lehman S., Williams G. et al. Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET/CT in patients with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation // J. Nucl. Med. - 2009. - Vol. 50. - P. 563-568.Wykrzykowska J., Lehman S., Williams G. et al. Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET/CT in patients with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation // J. Nucl. Med. - 2009. - Vol. 50. - P. 563-568.Xia W., Hilgenbrink A.R., Matteson E.L. et al. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages // Blood. - 2009. - Vol. 113. - P. 438-446.Xia W., Hilgenbrink A.R., Matteson E.L. et al. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages // Blood. - 2009. - Vol. 113. - P. 438-446.Yun M., Jang S., Cucchiara A. et al. 18F FDG uptake in thelarge arteries: a correlation study with the atherogenic risk factors // Semin. Nucl. Med. - 2002. - Vol. 32. - P. 70-76.Yun M., Jang S., Cucchiara A. et al. 18F FDG uptake in thelarge arteries: a correlation study with the atherogenic risk factors // Semin. Nucl. Med. - 2002. - Vol. 32. - P. 70-76.Zhao Y., Kuge Y., Zhao S. et al. Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE-/- mice // Eur. J. Nucl. Med. Mol. Imaging. - 2007. - Vol. 34. -P. 1747-1755.Zhao Y., Kuge Y., Zhao S. et al. Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE-/- mice // Eur. J. Nucl. Med. Mol. Imaging. - 2007. - Vol. 34. -P. 1747-1755.

The authors declare that there are no conflicts of interest present.