cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2018-33-3-30-35cardiotomsk-552Research ArticleКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯCLINICAL STUDIESВОССТАНОВЛЕНИЕ ФУНКЦИИ КОНДУИТА РАДИАЛЬНОЙ АРТЕРИИ ДЛЯ ШУНТИРОВАНИЯ КОРОНАРНОЙ АРТЕРИИFUNCTIONAL RECOVERY OF RADIAL ARTERY CONDUIT FOR CORONARY ARTERY BYPASS GRAFTINGРиппТ. М.RippT. M.

д-р мед. наук, старший научный сотрудник отделения артериальных гипертоний

634012, Российская Федерация, Томск, ул. Киевская, 111а

Dr. Sci. (Med.), Senior Research Fellow, Department of Arterial Hypertension

111a, Kievskaya str., Tomsk, 634012, Russian Federation

tatiana.m.ripp@gmail.comКондратьеваД. С.KondratievaD. S.

канд. мед. наук, научный сотрудник лаборатории молекулярно-клеточной патологии и генодиагностики

634012, Российская Федерация, Томск, ул. Киевская, 111а

Cand. Sci. (Med.), Research Fellow, Laboratory of Molecular and Cellular Pathology and Gene Diagnostics

111a, Kievskaya str., Tomsk, 634012, Russian Federation

АфанасьевС. А.AfanasievS. A.

д-р мед. наук, профессор, заведующий лабораторией молекулярно-клеточной патологии и генодиагностики

634012, Российская Федерация, Томск, ул. Киевская, 111а

Dr. Sci. (Med.), Professor, Head of the Laboratory of Molecular and Cellular Pathology and Gene Diagnostics

111a, Kievskaya str., Tomsk, 634012, Russian Federation

МуслимоваЭ. Ф.MuslimovaE. F.

канд. мед. наук, научный сотрудник лаборатории молекулярно-клеточной патологии и генодиагностики

634012, Российская Федерация, Томск, ул. Киевская, 111а

Cand. Sci. (Med.), Research Fellow, Laboratory of Molecular and Cellular Pathology and Gene Diagnostics

111a, Kievskaya str., Tomsk, 634012, Russian Federation

КозловБ. Н.KozlovB. N.

д-р мед. наук, ведущий научный сотрудник отделения сердечно-сосудистой хирургии

634012, Российская Федерация, Томск, ул. Киевская, 111а

Dr. Sci. (Med.), Leading Research Fellow, Department of Cardiosurgery

111a, Kievskaya str., Tomsk, 634012, Russian Federation

МордовинВ. Ф.MordovinV. F.

д-р мед. наук, профессор, заведующий отделением артериальных гипертоний

634012, Российская Федерация, Томск, ул. Киевская, 111а

Dr. Sci. (Med.), Professor, Head of the Department of Arterial Hypertension

111a, Kievskaya str., Tomsk, 634012, Russian Federation

Научно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наукРоссияCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesRussian Federation2018261120183333035Copyright © Рипп Т.М., Кондратьева Д.С., Афанасьев С.А., Муслимова Э.Ф., Козлов Б.Н., Мордовин В.Ф., 20182018Рипп Т.М., Кондратьева Д.С., Афанасьев С.А., Муслимова Э.Ф., Козлов Б.Н., Мордовин В.Ф.Ripp T.M., Kondratieva D.S., Afanasiev S.A., Muslimova E.F., Kozlov B.N., Mordovin V.F.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/552

Авторы изучили влияние лерканидипина на функциональное состояние лучевой артерии, используемой в качестве шунта для аортокоронарного шунтирования у пациентов со стенозом коронарной артерии. Эндотелийзависимую вазодилатацию (ΔD) оценивали до операции с использованием ультразвука. Пациенты были разделены на группы I и II с ΔD≥8% и ΔD<8% соответственно. Группа II была разделена на группы IIA (лерканидипин) и IIB (контроль). Механический тонус изолированных сегментов артерии была первоначально ниже в группе I. Предоперационная терапия лерканидипином (2,5–5 мг/кг в течение 5–7 дней) приводила к значительному увеличению эндотелийзависимой вазодилатации и уменьшению тонуса выделенных сегментов артерии. Предоперационное лечение лерканидипином эффективно сохраняло дилатационные свойства артериального канала.

The authors have studied the effect of lercanidipine on the functional status of radial artery used as conduit for CABG in patients with coronary artery stenosis. Endothelium-dependent vasodilation (ΔD) was evaluated preoperatively by using duplex ultrasound. Patients were divided into groups I and II with ΔD≥8% and ΔD<8%, respectively. Group II was divided into groups IIA (lercanidipine) and IIB (control). Mechanical force of isolated arterial segments was initially lower in group I. Preoperative treatment with lercanidipine (2.5–5 mg/kg for 5–7 days) led to a significant increase in endothelium-dependent vasodilation and decrease in tone of isolated arterial segments. Preoperative treatment with lercanidipine effectively preserved dilatational properties of arterial conduit.

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The authors declare that there are no conflicts of interest present.