cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2019-34-1-145-151cardiotomsk-694Research ArticleОРГАНИЗАЦИЯ ЗДРАВООХРАНЕНИЯ И ОБЩЕСТВЕННОЕ ЗДОРОВЬЕHEALTHCARE AND PUBLIC HEALTHПРОЦЕНТИЛЬНОЕ РАСПРЕДЕЛЕНИЕ ТОЛЩИНЫ КОМПЛЕКСА «ИНТИМА-МЕДИА» В ОБЩЕЙ ПОПУЛЯЦИИ ТРУДОСПОСОБНОГО ВОЗРАСТАPERCENTILE DISTRIBUTION OF CAROTID INTIMA-MEDIA THICKNESS IN THE GENERAL WORKING-AGE POPULATIONhttps://orcid.org/0000-0002-0211-4525КавешниковВ. С.KaveshnikovKaveshnikov

канд. мед. наук, старший научный сотрудник отделения популяционной кардиологии, 

634012, Томск, ул. Киевская, 111а

Cand. Sci. (Med.), Senior Researcher, Department of Cardiovascular Epidemiology, Cardiology Research Institute,

111a, Kievskaya str., Tomsk, 634012

kave@ngs.ruhttps://orcid.org/0000-0002-9265-708XСеребряковаВ. Н.SerebryakovaV. N.

канд. мед. наук, старший научный сотрудник отделения популяционной кардиологии,

634012, Томск, ул. Киевская, 111а

Cand. Sci. (Med.), Senior Researcher, Department of Cardiovascular Epidemiology,

111a, Kievskaya str., Tomsk, 634012

vsk75@yandex.ruhttps://orcid.org/0000-0003-1063-7382ТрубачеваИ. А.TrubachevaI. A.

д-р мед. наук, руководитель отделения популяционной кардиологии,

634012, Томск, ул. Киевская, 111а

Dr. Sci. (Med.), Head of the Department of Cardiovascular Epidemiology, Research Institute of Cardiology,

111a, Kievskaya str., Tomsk, 634012

tia@cardio-tomsk.ruНаучно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наукРоссияCardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of SciencesRussian Federation201922042019341145151Copyright © Кавешников В.С., Серебрякова В.Н., Трубачева И.А., 20192019Кавешников В.С., Серебрякова В.Н., Трубачева И.А.Kaveshnikov K., Serebryakova V.N., Trubacheva I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/694Цель

Цель: изучить в гендерно-возрастном аспекте процентильное распределение толщины комплекса «интима-медиа» (ТИМ) в неорганизованной городской популяции трудоспособного возраста.

Материал и методы

Материал и методы. Представлены данные, полученные в рамках исследования ЭССЕ-РФ в г. Томске (1412 человек 25–64 лет без сердечно-сосудистых заболеваний — ССЗ, женщины — 59%). Все обследованные подписывали добровольное информированное согласие на участие в исследовании. Изучали распределение средней (срТИМ) и максимальной ТИМ (максТИМ) общей сонной артерии (ОСА), полученное методами автоматического и ручного измерения соответственно. Вероятность ошибки менее 5% считали статистически значимой.

Результаты

Результаты. Показатели ТИМ последовательно увеличивались с возрастом у представителей обоих полов. МаксТИМ возрастала более интенсивно, чем срТИМ. По сравнению с данными других исследований показатели медианы срТИМ распределялись ближе к верхнему полюсу представленного спектра; более интенсивно возрастали в сегменте 35–55 лет у мужчин по сравнению с популяциями Центральной и Юго-Западной Европы; демонстрировали наиболее выраженные гендерные различия. Некоторые схожие тенденции выявлены и в отношении максТИМ.

Заключение

Заключение. Полученные данные дают возможность специфической оценки индивидуальных значений ТИМ по возрасту и полу, проводимой в рамках стратификации риска среди лиц трудоспособного возраста без ССЗ. Дальнейшие исследования, направленные на выяснение прогностической роли высоких популяционных значений ТИМ с учетом влияния традиционных и новых факторов риска (ФР) ССЗ, могут расширить представление о значении оценки состояния сосудов как одного из ключевых факторов, связывающих ФР с клиническими событиями, для первичной профилактики ССЗ среди населения.

Objective

Objective. To study the gender- and age-specific percentile distribution of carotid intima-media thickness (cIMT) in the unorganized urban working-age population.

Material and Methods

Material and Methods. Presented data were obtained in the ESSE-RF study in the city of Tomsk (1,412 participants, 25–64 years old without cardiovascular diseases, 59% women). All the surveyed signed voluntary informed consent form to participate in the study. We studied distributions of the mean and maximum cIMT obtained by the automatic and manual measurements, respectively. An error probability of less than 5% was considered statistically significant.

Results

Results. Both indicators of cIMT consistently increased with age in both gender groups. Maximum cIMT (max-cIMT) increased stronger than the mean cIMT (mean-cIMT). Compared with data obtained in other studies, the mean-cIMT estimates were distributed closer to the upper pole of the spectrum presented and increased stronger in 35–55-year-old men compared with those in the populations of Central and Southwestern Europe; the mean-cIMT estimates showed the most pronounced gender effect. Similar trends were identified in relation to the max-cIMT distribution.

Conclusion

Conclusion. Obtained data allowed for specific assessment of the individual cIMT values by gender and age within the framework of risk stratification among people of working age without cardiovascular diseases. Further studies aimed at clarifying the prognostic role of high cIMT values in general population, taking into account the influence of traditional and new cardiovascular risk factors, can broaden the understanding of the significance of vascular state assessment as one of the key points, linking risk factors to clinical events, for primary prevention of cardiovascular diseases in population.

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The authors declare that there are no conflicts of interest present.