cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2014-29-2-14-21cardiotomsk-72Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESО возможностях применения прямого ингибитора ренина алискирена для лечения социально значимых заболеванийProspects for the use of direct renin inhibitor aliskiren for the treatment of socially significant diseasesКолпаковаАлла ФедоровнаKolpakovaA. F.kolpakova44@mail.ruФГБУ “Конструкторско-технологичес кий институт вычислительной техники” СО РАНРоссияDesign Technological Institute of Digital Techniques SB RASRussian Federation2014060920162921421Copyright © Колпакова А.Ф., 20162016Колпакова А.Ф.Kolpakova A.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/72

В обзоре проанализированы результаты рандомизированных исследований эффективности и безопасности прямого ингибитора ренина алискирена при лечении больных артериальной гипертонией в сочетании с ожирением, сахарным диабетом, менопаузой и поражением почек; хронической болезнью почек, метаболическим синдромом. Установлено, что алискирен обладает не только гипотензивным, но кардио- и ренопротективным действием, что может расширить показания к его применению.

This review analyzes the results of randomized studies of the efficacy and safety of direct renin inhibitor aliskiren in the treatment of patients with arterial hypertension associated with obesity, diabetes, menopause, kidney failure, chronic kidney disease, and metabolic syndrome. The authors conclude that, along with the hypotensive action, aliskiren exerts cardioprotective and renoprotective effects that can expand the indications for the use of this drug.

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The authors declare that there are no conflicts of interest present.