cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2019-34-2-21-25cardiotomsk-756Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESКОРОНАРНЫЙ АТЕРОСКЛЕРОЗ И НАРУШЕНИЯ РИТМА СЕРДЦАCORONARY ATHEROSCLEROSIS AND CARDIAC ARRHYTHMIAShttps://orcid.org/0000-0003-1436-8853ЯрославскаяЕ. И.YaroslavskayaE. I.

д-р мед. наук, исполняющая обязанности заведующего научным отделом инструментальных методов исследования и лабораторией инструментальной диагностики, ведущий научный сотрудник лаборатории инструментальной диагностики, врач отделения ультразвуковых методов исследования

625026, Российская Федерация, Тюмень, ул. Мельникайте, 111

M.D., Dr. Sci. (Med.), Acting Director of Instrumental Diagnostic Department and Laboratory of Instrumental Research Methods, Leading Researcher of Laboratory of Instrumental Research Methods, Doctor of Ultrasound Diagnostics

111, Melnikaite str., Tyumen, 625026, Russian Federation

yaroslavskayae@gmail.comАксеноваК. В.AksenovaK. V.

врач-кардиолог

625026, Российская Федерация, Тюмень, ул. Мельникайте, 111

Cardiologist

111, Melnikaite str., Tyumen, 625026, Russian Federation

K-medicus@yandex.ruТюменский кардиологический научный центр, Томский национальный исследовательский медицинский центр Российской академии наукРоссияTyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of SciencesRussian Federation2019080720193422125Copyright © Ярославская Е.И., Аксенова К.В., 20192019Ярославская Е.И., Аксенова К.В.Yaroslavskaya E.I., Aksenova K.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/756

Развитие нарушений ритма сердца ассоциируется с ухудшением качества жизни пациентов, возникновением тромбоэмболических осложнений, внезапной сердечной смертью. В основе сердечных аритмий зачастую лежит коронарный атеросклероз. Гипоксия миокарда, его ремоделирование ведут к нарушениям возникновения и проведения электрических импульсов в сердце, развитию эктопических очагов возбуждения. В обзоре отражены основные патогенетические механизмы развития различных нарушений ритма сердца при атеросклеротическом поражении коронарных артерий.

Cardiac arrhythmias are associated with deterioration in patient’s quality of life, thromboembolic complications, and sudden cardiac death. Coronary atherosclerosis is often the cause of cardiac arrhythmias. Myocardial hypoxia and remodeling lead to impaired formation and conduction of the impulse and the development of ectopic rhythm. The article reviews the main pathogenetic mechanisms for various types of cardiac arrhythmias in patients with atherosclerotic coronary lesions.

коронарный атеросклерознарушение сердечного ритмафибрилляция предсердийcoronary atherosclerosiscardiac arrhythmiasatrial fibrillationReferencesWolf D., Ley K. Immunity and Inflammation in Atherosclerosis. Circ. Res. 2019;124(2):315–327. DOI: 10.1161/CIRCRESAHA.118.313591.Wolf D., Ley K. Immunity and Inflammation in Atherosclerosis. Circ. Res. 2019;124(2):315–327. DOI: 10.1161/CIRCRESAHA.118.313591.Кузнецов В.А., Ярославская Е.И. Коронарный атеросклероз: данные Тюменского регистра. Часть 1. Тюмень: ООО «Издательско-полиграфический центр «Экспресс»; 2018:204.Kuznecov V.A., Yaroslavskaya E.I. Coronary atherosclerosis: data from the Tyumen Registry (Part 1). Tyumen: OOO «Izdatel’sko-poligraficheskij centr «Jekspress»; 2018:204 (In Russ.).The World Health Organization. The top ten causes of death. https://www.who.int/en/news-room/fact-sheets/detail/the-top-10-causes-ofdeath (24 May 2018).The World Health Organization. The top ten causes of death. https://www.who.int/en/news-room/fact-sheets/detail/the-top-10-causes-ofdeath (24 May 2018).Кушаковский М.С. Аритмии сердца (причины, механизмы, электрокардиографическая и электрофизиологическая диагностика, клиника, лечение). Руководство для врачей. СПб.: «ГИППОКРАТ»; 1992:524.The World Health Organization. The top ten causes of death. https://www.who.int/en/news-room/fact-sheets/detail/the-top-10-causes-ofdeath (24 May 2018).Nattel St., Harada M. Atrial Remodeling and Atrial Fibrillation: Recent Advances and Translational Perspectives. J. Am. Coll. Cardiol. 2014;63(22):2335–2345. DOI: 10.1016/j.jacc.2014.02.555.Kushakovskij M.S. Heart arrhythmias (causes, mechanisms, electrocardiographic and electrophysiological diagnostics, clinic, treatment). A guide for doctors. Saint Petersburg: “GIPPOKRAT”; 1992:524 (In Russ.).Ялымов А.А., Задионченко В.С., Шехян Г.Г., Щикота А.М., Тимофеева Н.Ю., Снеткова А.А. Диагностика и лечение синдрома слабости синусового узла. Российский медицинский журнал. 2012;25:1309-1316.Kushakovskij M.S. Heart arrhythmias (causes, mechanisms, electrocardiographic and electrophysiological diagnostics, clinic, treatment). A guide for doctors. Saint Petersburg: “GIPPOKRAT”; 1992:524 (In Russ.).Pun P.H. The interplay between chronic kidney disease, sudden cardiac death, and ventricular arrhythmias. Advances in Chronic Kidney Disease. 2014;21(6):480–488. DOI: 10.1053/j.ackd.2014.06.007.Nattel St., Harada M. Atrial Remodeling and Atrial Fibrillation: Recent Advances and Translational Perspectives. J. Am. Coll. Cardiol. 2014;63(22):2335–2345. DOI: 10.1016/j.jacc.2014.02.555.Сыркин А.Л. (ред.). Неотложная кардиология: Руководство для врачей. 2-е изд. М.: ООО «Издательство МИА»; 2015:448.Nattel St., Harada M. Atrial Remodeling and Atrial Fibrillation: Recent Advances and Translational Perspectives. J. Am. Coll. Cardiol. 2014;63(22):2335–2345. DOI: 10.1016/j.jacc.2014.02.555.Kirchhof P., Benussi S., Kotecha D., Ahlsson A., Atar D., Casadei B., et al. Epidemiology and impact for patients. In ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur. Heart J. 2016;37(38):2893–2962. DOI: 10.1093/eurheartj/ehw210.Yalymov А.А., Zadionchenko V.S., Shekhyan G.G., Shhikota А.M., Timofeeva N.YU., Snetkova А.А. Diagnostics and treatment of sick sinus syndrome. Rossiiskii Meditsinskii Zhurnal=Medical Journal of the Russian Federation. 2012;25:1309–1316 (In Russ.).Haim M., Hoshen M., Reges O., Rabi Y., Balicer R., Leibowitz M. Prospective national study of the prevalence, incidence, management and outcome of a large contemporary cohort of patients with incident non-valvular atrial fibrillation. JAHA. 2015;4(1):e001486. DOI: 10.1161/JAHA.114.001486.Yalymov А.А., Zadionchenko V.S., Shekhyan G.G., Shhikota А.M., Timofeeva N.YU., Snetkova А.А. Diagnostics and treatment of sick sinus syndrome. Rossiiskii Meditsinskii Zhurnal=Medical Journal of the Russian Federation. 2012;25:1309–1316 (In Russ.).Lloyd-Jones D.M., Wang T.J., Leip E.P., Larson M.G., Levy D., Vasan R.S., et al. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation. 2004;110:1042–1046. DOI: 10.1161/01.CIR.0000140263.20897.42.Pun P.H. The interplay between chronic kidney disease, sudden cardiac death, and ventricular arrhythmias. Advances in Chronic Kidney Disease. 2014;21(6):480–488. DOI: 10.1053/j.ackd.2014.06.007.Schnabel R.B., Yin X., Gona P., Larson M.G., Beiser A.S., McManus D.D., et al. 50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study. Lancet. 2015;386(9989):154–162. DOI: 10.1016/S0140-6736(14)61774-8.Pun P.H. The interplay between chronic kidney disease, sudden cardiac death, and ventricular arrhythmias. Advances in Chronic Kidney Disease. 2014;21(6):480–488. DOI: 10.1053/j.ackd.2014.06.007.Nucifora G., Schuijf J.D., van Werkhoven J.M., Trines S.A., Kajander S., Tops L.F., et al. Relationship between obstructive coronary artery disease and abnormal stress testing in patients with paroxysmal or persistent atrial fibrillation. The International Journal of Cardiovascular Imaging. 2011;27(6):777–785. DOI: 10.1007/s10554-010-9725-x.Syrkin A.L. (ed.). Emergency Cardiology: A Guide for Doctors. 2th ed. Мoscow: OOO «Izdatel’stvo MIA»; 2015:448 (In Russ.).Tomomatsu T., Morishima I., Okumura K., Tsuboi H., Morita Y., Takagi K., et al. Comparison of frequency and characteristics of patients with atrial fibrillation having ablation with versus without coronary narrowing (≥50%) by Angiography. Am. J. Cardiol. 2017;119(11):1770–1775. DOI: 10.1016/j.amjcard.2017.02.047.Syrkin A.L. (ed.). Emergency Cardiology: A Guide for Doctors. 2th ed. Мoscow: OOO «Izdatel’stvo MIA»; 2015:448 (In Russ.).Батурина О.А., Андреев Д.А., Ананичева Н.А., Гиляров М.Ю., Сычев Д.А., Сыркин А.Л., и др. Распространенность фибрилляции предсердий при остром коронарном синдроме и особенности назначения пероральных антитромботических препаратов. Кардиология. 2019;59(1):40–48. DOI: 10.18087/cardio.2019.1.10213.Kirchhof P., Benussi S., Kotecha D., Ahlsson A., Atar D., Casadei B., et al. Epidemiology and impact for patients. In ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur. Heart J. 2016;37(38):2893–2962. DOI: 10.1093/eurheartj/ehw210.Csige I., Ujvárosy D., Szabó Z., Lőrincz I., Paragh G., Harangi M., et al. The Impact of Obesity on the Cardiovascular System. Journal of Diabetes Research. 2018;2018:3407306. DOI: 10.1155/2018/3407306.Kirchhof P., Benussi S., Kotecha D., Ahlsson A., Atar D., Casadei B., et al. Epidemiology and impact for patients. In ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur. Heart J. 2016;37(38):2893–2962. DOI: 10.1093/eurheartj/ehw210.Lee S.H., Chen Y.C., Chen Y.J., Chang S.L., Tai C.T., Wongcharoen W., et al. Tumor necrosis factor-α alters calcium handling and increases arrhythmogenesis of pulmonary vein cardiomyocytes. Life Sci. 2007;80(19):1806–1815. DOI: 10.1016/j.lfs.2007.02.029.Haim M., Hoshen M., Reges O., Rabi Y., Balicer R., Leibowitz M. Prospective national study of the prevalence, incidence, management and outcome of a large contemporary cohort of patients with incident non-valvular atrial fibrillation. JAHA. 2015;4(1):e001486. DOI: 10.1161/JAHA.114.001486.Chung M.K., Martin D.O., Sprecher D., Wazni O., Kanderian A., Carnes C.A., et al. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Circulation. 2001;104(24):2886–2891.Haim M., Hoshen M., Reges O., Rabi Y., Balicer R., Leibowitz M. Prospective national study of the prevalence, incidence, management and outcome of a large contemporary cohort of patients with incident non-valvular atrial fibrillation. JAHA. 2015;4(1):e001486. DOI: 10.1161/JAHA.114.001486.Kinoshita T., Asai T., Takashima N., Hosoba S., Suzuki T., Kambara A., et al. Preoperative C-reactive protein and atrial fibrillation after off-pump coronary bypass surgery. Eur. J. Cardiothorac. Surg. 2011;40(6):1298–1303. DOI: 10.1016/j.ejcts.2011.03.027.Lloyd-Jones D.M., Wang T.J., Leip E.P., Larson M.G., Levy D., Vasan R.S., et al. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation. 2004;110:1042–1046. DOI: 10.1161/01.CIR.0000140263.20897.42.Li S., Zhang Z., Scherlag B.J., Po S.S. Atrial fibrillation in athletes the story behind the running hearts. Journal of Atrial Fibrillation. 2010;2(5):231. DOI: 10.4022/jafib.231.Lloyd-Jones D.M., Wang T.J., Leip E.P., Larson M.G., Levy D., Vasan R.S., et al. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation. 2004;110:1042–1046. DOI: 10.1161/01.CIR.0000140263.20897.42.Nalliah C.J., Sanders P., Kottkamp H., Kalman J.M. The role of obesity in atrial fibrillation. Eur. Heart J. 2016;37(20):1565–1572. DOI: 10.1093/eurheartj/ehv486.Schnabel R.B., Yin X., Gona P., Larson M.G., Beiser A.S., McManus D.D., et al. 50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study. Lancet. 2015;386(9989):154–162. DOI: 10.1016/S0140-6736(14)61774-8.Драпкина О.М., Николаева М.В. Патогенетические механизмы развития фибрилляции предсердий при ожирении. Рациональная Фармакотерапия в Кардиологии. 2016;12(5):582–589. DOI: 10.20996/1819-6446-2016-12-5-582-589.Schnabel R.B., Yin X., Gona P., Larson M.G., Beiser A.S., McManus D.D., et al. 50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study. Lancet. 2015;386(9989):154–162. DOI: 10.1016/S0140-6736(14)61774-8.Goudis C.A., Korantzopoulos P., Ntalas I.V., Ntalas I.V., Kallergis E.M., Ketikoglou D.G. Obesity and atrial fibrillation: A comprehensive review of the pathophysiological mechanisms and links. J. Cardiol. 2015;66(5):361–369. DOI: 10.1016/j.jjcc.2015.04.002.Nucifora G., Schuijf J.D., van Werkhoven J.M., Trines S.A., Kajander S., Tops L.F., et al. Relationship between obstructive coronary artery disease and abnormal stress testing in patients with paroxysmal or persistent atrial fibrillation. The International Journal of Cardiovascular Imaging. 2011;27(6):777–785. DOI: 10.1007/s10554-010-9725-x.Енина Т.Н., Кузнецов В.А., Саламова Л.А., Солдатова А.М. Биомаркеры иммунного воспаления, фиброза, нейрогуморальной активации и катехоламины у больных с устройствами для кардиоверсии-дефибрилляции и сердечной ресинхронизирующей терапии. Материалы Национального конгресса «Сердечная недостаточность, 2018». М.; 14-15 декабря 2018:23.Nucifora G., Schuijf J.D., van Werkhoven J.M., Trines S.A., Kajander S., Tops L.F., et al. Relationship between obstructive coronary artery disease and abnormal stress testing in patients with paroxysmal or persistent atrial fibrillation. The International Journal of Cardiovascular Imaging. 2011;27(6):777–785. DOI: 10.1007/s10554-010-9725-x.Tomomatsu T., Morishima I., Okumura K., Tsuboi H., Morita Y., Takagi K., et al. Comparison of frequency and characteristics of patients with atrial fibrillation having ablation with versus without coronary narrowing (≥50%) by angiography. Am. J. Cardiol. 2017;119(11):1770–1775. DOI: 10.1016/j.amjcard.2017.02.047.Tomomatsu T., Morishima I., Okumura K., Tsuboi H., Morita Y., Takagi K., et al. Comparison of frequency and characteristics of patients with atrial fibrillation having ablation with versus without coronary narrowing (≥50%) by angiography. Am. J. Cardiol. 2017;119(11):1770–1775. DOI: 10.1016/j.amjcard.2017.02.047.Tomomatsu T., Morishima I., Okumura K., Tsuboi H., Morita Y., Takagi K., et al. Comparison of frequency and characteristics of patients with atrial fibrillation having ablation with versus without coronary narrowing (≥50%) by angiography. Am. J. Cardiol. 2017;119(11):1770–1775. DOI: 10.1016/j.amjcard.2017.02.047.Tomomatsu T., Morishima I., Okumura K., Tsuboi H., Morita Y., Takagi K., et al. Comparison of frequency and characteristics of patients with atrial fibrillation having ablation with versus without coronary narrowing (≥50%) by angiography. Am. J. Cardiol. 2017;119(11):1770–1775. DOI: 10.1016/j.amjcard.2017.02.047.Baturina O.A., Andreev D.A., Ananicheva N.A., Gilyarov M.Y., Sychev D.A., Syrkin A.L., Shchekochihin D.Y. Prevalence of Atrial Fibrillation and use of Oral Antithrombotic Therapy in Patients with Acute Coronary Syndrome. Kardiologiia. 2019;59(1):40–48 (In Russ.). DOI: 10.18087/cardio.2019.1.10213.Baturina O.A., Andreev D.A., Ananicheva N.A., Gilyarov M.Y., Sychev D.A., Syrkin A.L., Shchekochihin D.Y. Prevalence of Atrial Fibrillation and use of Oral Antithrombotic Therapy in Patients with Acute Coronary Syndrome. Kardiologiia. 2019;59(1):40–48 (In Russ.). DOI: 10.18087/cardio.2019.1.10213.Baturina O.A., Andreev D.A., Ananicheva N.A., Gilyarov M.Y., Sychev D.A., Syrkin A.L., Shchekochihin D.Y. Prevalence of Atrial Fibrillation and use of Oral Antithrombotic Therapy in Patients with Acute Coronary Syndrome. Kardiologiia. 2019;59(1):40–48 (In Russ.). DOI: 10.18087/cardio.2019.1.10213.Baturina O.A., Andreev D.A., Ananicheva N.A., Gilyarov M.Y., Sychev D.A., Syrkin A.L., Shchekochihin D.Y. Prevalence of Atrial Fibrillation and use of Oral Antithrombotic Therapy in Patients with Acute Coronary Syndrome. Kardiologiia. 2019;59(1):40–48 (In Russ.). DOI: 10.18087/cardio.2019.1.10213.Csige I., Ujvárosy D., Szabó Z., Lőrincz I., Paragh G., Harangi M., et al. The Impact of Obesity on the Cardiovascular System. Journal of Diabetes Research. 2018;2018:3407306. DOI: 10.1155/2018/3407306.Csige I., Ujvárosy D., Szabó Z., Lőrincz I., Paragh G., Harangi M., et al. The Impact of Obesity on the Cardiovascular System. Journal of Diabetes Research. 2018;2018:3407306. DOI: 10.1155/2018/3407306.Csige I., Ujvárosy D., Szabó Z., Lőrincz I., Paragh G., Harangi M., et al. The Impact of Obesity on the Cardiovascular System. Journal of Diabetes Research. 2018;2018:3407306. DOI: 10.1155/2018/3407306.Csige I., Ujvárosy D., Szabó Z., Lőrincz I., Paragh G., Harangi M., et al. The Impact of Obesity on the Cardiovascular System. Journal of Diabetes Research. 2018;2018:3407306. DOI: 10.1155/2018/3407306.Lee S.H., Chen Y.C., Chen Y.J., Chang S.L., Tai C.T., Wongcharoen W., et al. Tumor necrosis factor-α alters calcium handling and increases arrhythmogenesis of pulmonary vein cardiomyocytes. Life Scie.2007;80(19):1806–1815. DOI: 10.1016/j.lfs.2007.02.029.Lee S.H., Chen Y.C., Chen Y.J., Chang S.L., Tai C.T., Wongcharoen W., et al. Tumor necrosis factor-α alters calcium handling and increases arrhythmogenesis of pulmonary vein cardiomyocytes. Life Scie.2007;80(19):1806–1815. DOI: 10.1016/j.lfs.2007.02.029.Lee S.H., Chen Y.C., Chen Y.J., Chang S.L., Tai C.T., Wongcharoen W., et al. Tumor necrosis factor-α alters calcium handling and increases arrhythmogenesis of pulmonary vein cardiomyocytes. Life Scie.2007;80(19):1806–1815. DOI: 10.1016/j.lfs.2007.02.029.Lee S.H., Chen Y.C., Chen Y.J., Chang S.L., Tai C.T., Wongcharoen W., et al. Tumor necrosis factor-α alters calcium handling and increases arrhythmogenesis of pulmonary vein cardiomyocytes. Life Scie.2007;80(19):1806–1815. DOI: 10.1016/j.lfs.2007.02.029.Chung M.K., Martin D.O., Sprecher D., Wazni O., Kanderian A., Carnes C.A., et al. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Circulation. 2001;104(24):2886–2891.Chung M.K., Martin D.O., Sprecher D., Wazni O., Kanderian A., Carnes C.A., et al. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Circulation. 2001;104(24):2886–2891.Chung M.K., Martin D.O., Sprecher D., Wazni O., Kanderian A., Carnes C.A., et al. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Circulation. 2001;104(24):2886–2891.Chung M.K., Martin D.O., Sprecher D., Wazni O., Kanderian A., Carnes C.A., et al. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Circulation. 2001;104(24):2886–2891.Kinoshita T., Asai T., Takashima N., Hosoba S., Suzuki T., Kambara A., et al. Preoperative C-reactive protein and atrial fibrillation after off-pump coronary bypass surgery. Eur. J. Cardiothorac. Surg. 2011;40(6):1298–1303. DOI: 10.1016/j.ejcts.2011.03.027.Kinoshita T., Asai T., Takashima N., Hosoba S., Suzuki T., Kambara A., et al. Preoperative C-reactive protein and atrial fibrillation after off-pump coronary bypass surgery. Eur. J. Cardiothorac. Surg. 2011;40(6):1298–1303. DOI: 10.1016/j.ejcts.2011.03.027.Kinoshita T., Asai T., Takashima N., Hosoba S., Suzuki T., Kambara A., et al. Preoperative C-reactive protein and atrial fibrillation after off-pump coronary bypass surgery. Eur. J. Cardiothorac. Surg. 2011;40(6):1298–1303. DOI: 10.1016/j.ejcts.2011.03.027.Kinoshita T., Asai T., Takashima N., Hosoba S., Suzuki T., Kambara A., et al. Preoperative C-reactive protein and atrial fibrillation after off-pump coronary bypass surgery. Eur. J. Cardiothorac. Surg. 2011;40(6):1298–1303. DOI: 10.1016/j.ejcts.2011.03.027.Li S., Zhang Z., Scherlag B.J., Po S.S. Atrial Fibrillation in athletes the story behind the running hearts. Journal of Atrial Fibrillation. 2010;2(5):231. DOI: 10.4022/jafib.231.Li S., Zhang Z., Scherlag B.J., Po S.S. Atrial Fibrillation in athletes the story behind the running hearts. Journal of Atrial Fibrillation. 2010;2(5):231. DOI: 10.4022/jafib.231.Li S., Zhang Z., Scherlag B.J., Po S.S. Atrial Fibrillation in athletes the story behind the running hearts. Journal of Atrial Fibrillation. 2010;2(5):231. DOI: 10.4022/jafib.231.Li S., Zhang Z., Scherlag B.J., Po S.S. Atrial Fibrillation in athletes the story behind the running hearts. Journal of Atrial Fibrillation. 2010;2(5):231. DOI: 10.4022/jafib.231.Nalliah C.J., Sanders P., Kottkamp H., Kalman J.M. The role of obesity in atrial fibrillation. Eur. Heart J. 2016;37(20):1565–1572. DOI: 10.1093/eurheartj/ehv486.Nalliah C.J., Sanders P., Kottkamp H., Kalman J.M. The role of obesity in atrial fibrillation. Eur. Heart J. 2016;37(20):1565–1572. DOI: 10.1093/eurheartj/ehv486.Nalliah C.J., Sanders P., Kottkamp H., Kalman J.M. The role of obesity in atrial fibrillation. Eur. Heart J. 2016;37(20):1565–1572. DOI: 10.1093/eurheartj/ehv486.Nalliah C.J., Sanders P., Kottkamp H., Kalman J.M. The role of obesity in atrial fibrillation. Eur. Heart J. 2016;37(20):1565–1572. DOI: 10.1093/eurheartj/ehv486.Drapkina O.M., Nikolaeva M.V. Pathogenic Mechanisms of Atrial Fibrillation in Obesity. Ratsionalnaya Farmakoterapiya v Kardiologii=Rational Pharmacotherapy in Cardiology. 2016;12(5):582–589 (In Russ.). DOI: 10.20996/1819-6446-2016-12-5-582-589.Drapkina O.M., Nikolaeva M.V. Pathogenic Mechanisms of Atrial Fibrillation in Obesity. Ratsionalnaya Farmakoterapiya v Kardiologii=Rational Pharmacotherapy in Cardiology. 2016;12(5):582–589 (In Russ.). DOI: 10.20996/1819-6446-2016-12-5-582-589.Drapkina O.M., Nikolaeva M.V. Pathogenic Mechanisms of Atrial Fibrillation in Obesity. Ratsionalnaya Farmakoterapiya v Kardiologii=Rational Pharmacotherapy in Cardiology. 2016;12(5):582–589 (In Russ.). DOI: 10.20996/1819-6446-2016-12-5-582-589.Drapkina O.M., Nikolaeva M.V. Pathogenic Mechanisms of Atrial Fibrillation in Obesity. Ratsionalnaya Farmakoterapiya v Kardiologii=Rational Pharmacotherapy in Cardiology. 2016;12(5):582–589 (In Russ.). DOI: 10.20996/1819-6446-2016-12-5-582-589.Goudis C.A., Korantzopoulos P., Ntalas I.V., Kallergis E.M., Ketikoglou D.G. Obesity and atrial fibrillation: A comprehensive review of the pathophysiological mechanisms and links. J. Cardiol. 2015;66(5):361–369. DOI: 10.1016/j.jjcc.2015.04.002.Goudis C.A., Korantzopoulos P., Ntalas I.V., Kallergis E.M., Ketikoglou D.G. Obesity and atrial fibrillation: A comprehensive review of the pathophysiological mechanisms and links. J. Cardiol. 2015;66(5):361–369. DOI: 10.1016/j.jjcc.2015.04.002.Goudis C.A., Korantzopoulos P., Ntalas I.V., Kallergis E.M., Ketikoglou D.G. Obesity and atrial fibrillation: A comprehensive review of the pathophysiological mechanisms and links. J. Cardiol. 2015;66(5):361–369. DOI: 10.1016/j.jjcc.2015.04.002.Goudis C.A., Korantzopoulos P., Ntalas I.V., Kallergis E.M., Ketikoglou D.G. Obesity and atrial fibrillation: A comprehensive review of the pathophysiological mechanisms and links. J. Cardiol. 2015;66(5):361–369. DOI: 10.1016/j.jjcc.2015.04.002.Enina T.N., Kuznetsov V.А., Salamova L.А., Soldatova А.M. Biomarkers of immune inflammation, fibrosis, neurohumoral activation and catecholamines in patients with cardioversion-defibrillation devices and cardiac resynchronization therapy. Proceedings of the National Congress «Heart Failure 2018»; 2018 Dec. 14-15; Congress-Holl Crocus, Мoscow, Russia. Moscow: Society of Specialists in Heart Failure; 2018:23.Enina T.N., Kuznetsov V.А., Salamova L.А., Soldatova А.M. Biomarkers of immune inflammation, fibrosis, neurohumoral activation and catecholamines in patients with cardioversion-defibrillation devices and cardiac resynchronization therapy. Proceedings of the National Congress «Heart Failure 2018»; 2018 Dec. 14-15; Congress-Holl Crocus, Мoscow, Russia. Moscow: Society of Specialists in Heart Failure; 2018:23.Enina T.N., Kuznetsov V.А., Salamova L.А., Soldatova А.M. Biomarkers of immune inflammation, fibrosis, neurohumoral activation and catecholamines in patients with cardioversion-defibrillation devices and cardiac resynchronization therapy. Proceedings of the National Congress «Heart Failure 2018»; 2018 Dec. 14-15; Congress-Holl Crocus, Мoscow, Russia. Moscow: Society of Specialists in Heart Failure; 2018:23.Enina T.N., Kuznetsov V.А., Salamova L.А., Soldatova А.M. Biomarkers of immune inflammation, fibrosis, neurohumoral activation and catecholamines in patients with cardioversion-defibrillation devices and cardiac resynchronization therapy. Proceedings of the National Congress «Heart Failure 2018»; 2018 Dec. 14-15; Congress-Holl Crocus, Мoscow, Russia. Moscow: Society of Specialists in Heart Failure; 2018:23.

The authors declare that there are no conflicts of interest present.