cardiotomskСибирский журнал клинической и экспериментальной медициныSiberian Journal of Clinical and Experimental Medicine2713-29272713-265XTSU publishing10.29001/2073-8552-2019-34-4-72-82cardiotomsk-866Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESНекодирующие РНК в диагностике пневмонииNon-coding RNAs in pneumonia diagnosishttps://orcid.org/0000-0002-0897-5473МихайловаС. В.MikhailovaS. V.

Михайлова Светлана Владимировна - кандидат биологических наук, научный сотрудник, лаборатория молекулярной генетики человека.

630090, Новосибирск, пр. Академика Лаврентьева, 10

Svetlana V. Mikhailova - Cand. Sci. (Biol.), Research Scientist, Laboratory of Human Molecular Genetics.

10, Lavrentiev ave., Novosibirsk, 630090

mikhail@bionet.nsc.ruhttps://orcid.org/0000-0002-0403-545XИванощукД. Е.IvanoshchukD. E.

Иванощук Динара Евгеньевна - младший научный сотрудник, лаборатория молекулярной генетики человека.

630090, Новосибирск, пр. Академика Лаврентьева, 10

Dinara E. Ivanoshchuk - Junior Research Scientist, Laboratory of Human Molecular Genetics.

10, Lavrentiev ave., Novosibirsk, 630090

dinara2084@mail.ruhttps://orcid.org/0000-0001-6108-1025ШахтшнейдерЕ. В.ShakhtshneyderE. V.

Шахтшнейдер Елена Владимировна - кандидат медицинских наук, ведущий научный сотрудник, лаборатория молекулярно-генетических исследований терапевтических заболеваний.

630089,           Новосибирск, ул. Б. Богаткова, 175/1

Elena V. Shakhtshneyder - Cand. Sci. (Med.), Leading Research Scientist, Laboratory of Molecular Genetic Studies of Therapeutic Diseases.

175/1, B. Bogatkova str., Novosibirsk, 630089

2117409@mail.ruhttps://orcid.org/0000-0003-3393-3192СтепановГ. А.StepanovG. A.

Степанов Григорий Александрович - кандидат биологических наук, заведующий лабораторией геномного редактирования.

630090,           Новосибирск, пр. Академика Лаврентьева, 8

Grigoriy A. Stepanov - Cand. Sci. (Biol.), Head of Genome Editing Laboratory.

8, Lavrentiev ave., Novosibirsk, 630090

stepanovg@ngs.ruhttps://orcid.org/0000-0003-1715-6530РозановА. С.RozanovA. S.

Розанов Алексей Сергеевич - кандидат биологических наук, научный сотрудник, заведующий сектором генетики промышленных микроорганизмов.

630090, Новосибирск, пр. Академика Лаврентьева, 10

Alexey S. Rozanov - Cand. Sci. (Biol.), Senior Research Scientist, Head of the Interinstitutional Junior Sector for Industrial Microbiology.

10, Lavrentiev ave., Novosibirsk, 630090

sibiryak.n@gmail.comhttps://orcid.org/0000-0002-3524-0456ПельтекС. Е.PeltekS. E.

Пельтек Сергей Евгеньевич - кандидат биологических наук, заведующий лабораторией молекулярных биотехнологий.

630090, Новосибирск, пр. Академика Лаврентьева, 10

Sergey E. Peltek - Cand. Sci. (Biol.), Head of the Laboratory of Molecular Biotechnologies.

10, Lavrentiev ave., Novosibirsk, 630090

peltek@bionet.nsc.ruhttps://orcid.org/0000-0001-9425-413XВоеводаМ. И.VoevodaM. I.

Воевода Михаил Иванович - доктор медицинских наук, профессор, академик РАН, руководитель научного направления фундаментальных и клинических исследований.

630089,           Новосибирск, ул. Б. Богаткова, 175/1

Mikhail I. Voevoda - Dr. Sci. (Med.), Full Member of the Russian Academy of Sciences, Head of the Scientific Direction of Fundamental and Clinical Research

175/1, B. Bogatkova str., Novosibirsk, 630089

voevoda@bionet.nsc.ruИнститут цитологии и генетики, Сибирское отделение Российская академия наукРоссияInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesRussian FederationНаучно-исследовательский институт терапии и профилактической медицины — филиал Федерального государственного бюджетного научного учреждения Федеральный исследовательский центр Институт цитологии и генетики, Сибирское отделение Российская академия наукРоссияInstitution of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of SciencesRussian FederationИнститут химической биологии и фундаментальной медицины, Сибирское отделение Российская академия наукРоссияInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of SciencesRussian FederationInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesRussian Federation2019240120203447282Copyright © Михайлова С.В., Иванощук Д.Е., Шахтшнейдер Е.В., Степанов Г.А., Розанов А.С., Пельтек С.Е., Воевода М.И., 20202020Михайлова С.В., Иванощук Д.Е., Шахтшнейдер Е.В., Степанов Г.А., Розанов А.С., Пельтек С.Е., Воевода М.И.Mikhailova S.V., Ivanoshchuk D.E., Shakhtshneyder E.V., Stepanov G.A., Rozanov A.S., Peltek S.E., Voevoda M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibjcem.ru/jour/article/view/866

Пневмония - тяжелое воспалительное заболевание, характеризующееся высокой смертностью во всем мире. Ранний диагноз внегоспитальной пневмонии и выявление вызвавшего ее инфекционного агента могут существенно снизить тяжесть ее течения и вероятность госпитализации пациента. Используемые на данный момент диагностические и прогностические методы не являются достаточно надежными, поэтому ряд специфических некодирующих РНК, циркулирующих в крови в составе внеклеточных везикул, рассматривают в последние годы как потенциальный биомаркер для дифференциации вирусных и бактериальных пневмоний, а также для предсказания осложнений и тяжести течения заболевания. В обзоре рассмотрены микроРНК, длинные некодирующие РНК и ксено-микроРНК, которые были предложены в качестве прогностических и диагностических маркеров, а также потенциальных тар-гетных препаратов при пневмонии.

Pneumonia is a severe inflammatory disease responsible for high mortality worldwide, with about four million deaths each year. Early diagnosis of community-acquired pneumonia and the identification of the infectious agent can significantly reduce a pneumonia severity, a likelihood of patient's hospitalization, and pandemic rise. However, the diagnostic methods currently used are not reliable enough. Therefore, certain specific non-coding RNAs circulating in the blood inside the extracellular vesicles have been considered a potential biomarker for differentiating viral and bacterial pneumonia, as well as for predictions of disease severity and complications. We reviewed microRNAs, long non-coding RNAs, and xeno-microRNAs, which were proposed as prognostic and diagnostic markers and potential target drugs for pneumonia.

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The authors declare that there are no conflicts of interest present.