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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский журнал клинической и экспериментальной медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian Journal of Clinical and Experimental Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2713-2927</issn><issn pub-type="epub">2713-265X</issn><publisher><publisher-name>TSU publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29001/2073-8552-2020-35-1-13-21</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiotomsk-908</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Нарушения ритма и проводимости сердца как проявления кардиотоксичности противоопухолевого лечения – миф или реальность?</article-title><trans-title-group xml:lang="en"><trans-title>Heart rhythm and conduction disorders as manifestations of cardiotoxicity of anticancer treatment: myth or reality?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2913-9797</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васюк</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasyuk</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>20/1, Delegatskaya str., Moscow, 117473, Russian Federation </p></bio><email xlink:type="simple">yvasyuk@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6188-4610</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шупенина</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Shupenina</surname><given-names>E. Y.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Cand. Sci. (Med.), Assistant Professor, Department of Clinical Functional Diagnostics</p><p>20/1, Delegatskaya str., Moscow, 117473, Russian Federation</p></bio><email xlink:type="simple">eshupenina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9873-8665</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новосел</surname><given-names>Е. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Novosel</surname><given-names>E. O.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Medical Resident, Department of Hospital Therapy No. 1</p><p>20/1, Delegatskaya str., Moscow, 117473, Russian Federation </p></bio><email xlink:type="simple">evgeniya.sechko@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7143-2087</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Агапов</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Agapov</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Medical Resident, Department of Hospital Therapy No. 1</p><p>20/1, Delegatskaya str., Moscow, 117473, Russian Federation </p></bio><email xlink:type="simple">vanyok.agapov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Московский государственный медико-стоматологический университет им. А.И. Евдокимова<country>Россия</country></aff><aff xml:lang="en">A.I. Yevdokimov Moscow State University of Medicine and Dentistry<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>09</day><month>04</month><year>2020</year></pub-date><volume>35</volume><issue>1</issue><fpage>13</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Васюк Ю.А., Шупенина Е.Ю., Новосел Е.О., Агапов И.С., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Васюк Ю.А., Шупенина Е.Ю., Новосел Е.О., Агапов И.С.</copyright-holder><copyright-holder xml:lang="en">Vasyuk Y.A., Shupenina E.Y., Novosel E.O., Agapov I.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sibjcem.ru/jour/article/view/908">https://www.sibjcem.ru/jour/article/view/908</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>кардиотоксичность</kwd><kwd>фибрилляция предсердий</kwd><kwd>синдром удлиненного интервала QT</kwd><kwd>антрациклины</kwd><kwd>моноклональные антитела</kwd><kwd>ингибиторы тирозинкиназ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiotoxicity</kwd><kwd>atrial fibrillation</kwd><kwd>QT prolongation syndrome</kwd><kwd>anthracyclines</kwd><kwd>monoclonal antibodies</kwd><kwd>tyrosine kinase inhibitors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Васюк Ю.А., Ющук Е.Н., Несветов В.В. Кардиоонкология: новый вызов нашего времени. Сердечно-сосудистые осложнения противоопухолевого лечения. М.: Клинмедконсалтинг; 2019:100.</mixed-citation><mixed-citation xml:lang="en">Vasyuk Y.A., Yushchuk E.N., Nesvetov V.V. Cardiooncology: a new challenge of our time. Cardiovascular complications of antitumor treatment. Moscow: KlinmedConsulting; 2019:100 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Zamorano J., Lancellotti P., Munoz D., Aboyans V., Asteggiano R., Galderisi M. et al. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines. Eur. Heart J. 2016;37(36):2768–2801. DOI: 10.1093/eurheartj/ehw211.</mixed-citation><mixed-citation xml:lang="en">Zamorano J., Lancellotti P., Munoz D., Aboyans V., Asteggiano R., Galderisi M. et al. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines. Eur. Heart J. 2016;37(36):2768–2801. DOI: 10.1093/eurheartj/ehw211.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Todaro M., Oreto L., Qamar R., Paterick T., Carerj S., Khandheria B. Cardioncology: state of the heart. Int. J. Cardiol. 2013;168:680–687.</mixed-citation><mixed-citation xml:lang="en">Todaro M., Oreto L., Qamar R., Paterick T., Carerj S., Khandheria B. Cardioncology: state of the heart. Int. J. Cardiol. 2013;168:680–687.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bhave M., Akhter N., Rosen S. Cardiovascular toxicity of biologic agents for cancer therapy. Oncology (Williston Park). 2014;28(6):482–490.</mixed-citation><mixed-citation xml:lang="en">Bhave M., Akhter N., Rosen S. Cardiovascular toxicity of biologic agents for cancer therapy. Oncology (Williston Park). 2014;28(6):482–490.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bowles E., Wellman R., Feigelson H., Onitilo A., Freedman A., Delate T. et al. Pharmacovigilance Study Team. Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study. J. Natl. Cancer Inst. 2012;104(17):1293–1305. DOI: 10.1093/jnci/djs317.</mixed-citation><mixed-citation xml:lang="en">Bowles E., Wellman R., Feigelson H., Onitilo A., Freedman A., Delate T. et al. Pharmacovigilance Study Team. Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study. J. Natl. Cancer Inst. 2012;104(17):1293–1305. DOI: 10.1093/jnci/djs317.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Yang X., Li X., Yuan M., Tian C., Yang Y., Wang X. et al. Anticancer therapy-induced atrial fibrillation: electrophysiology and related mechanisms. Front. Pharmacol. 2018;9:1058. DOI: 10.3389/fphar.2018.01058.</mixed-citation><mixed-citation xml:lang="en">Yang X., Li X., Yuan M., Tian C., Yang Y., Wang X. et al. Anticancer therapy-induced atrial fibrillation: electrophysiology and related mechanisms. Front. Pharmacol. 2018;9:1058. DOI: 10.3389/fphar.2018.01058.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Varga Z.V., Ferdinandy P., Liaudet L., Pacher P. Drug-induced mitochondrial dysfunction and cardiotoxicity. Am. J. Phys. Heart Circ. Phys. 2015;309(9):1453–1467. DOI: 10.1152/ajpheart.00554.2015.</mixed-citation><mixed-citation xml:lang="en">Varga Z.V., Ferdinandy P., Liaudet L., Pacher P. Drug-induced mitochondrial dysfunction and cardiotoxicity. Am. J. Phys. Heart Circ. Phys. 2015;309(9):1453–1467. DOI: 10.1152/ajpheart.00554.2015.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y., Tan D., Shi L., Liu X., Zhang Y., Tong C. et al. Blueberry anthocyanins enriched extracts attenuate cyclophosphamide-induced cardiac injury. PLoS One. 2015;10(7):e0127813. DOI: 10.1371/journal.pone.0127813.</mixed-citation><mixed-citation xml:lang="en">Liu Y., Tan D., Shi L., Liu X., Zhang Y., Tong C. et al. Blueberry anthocyanins  enriched extracts attenuate cyclophosphamide-induced cardiac injury. PLoS One. 2015;10(7):e0127813. DOI: 10.1371/journal.pone.0127813.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Martinello R., Becco P., Vici P., Airoldi M., Del Mastro L., Garrone O. et al. Trastuzumab-related cardiotoxicity in patients with nonlimiting cardiac comorbidity. Breast J. 2019;25(3):444–449. DOI: 10.1111/tbj.13240.</mixed-citation><mixed-citation xml:lang="en">Martinello R., Becco P., Vici P., Airoldi M., Del Mastro L., Garrone O. et al. Trastuzumab-related cardiotoxicity in patients with nonlimiting cardiac comorbidity. Breast J. 2019;25(3):444–449. DOI: 10.1111/tbj.13240.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Yuan M., Tse G., Zhang Z., Han X., Wu W.K.K., Li G. et al. The incidence of atrial fibrillation with trastuzumab treatment: A systematic review and meta-analysis. Cardiovasc. Ther. 2018;36(6):e12475. DOI: 10.1111/1755-5922.12475.</mixed-citation><mixed-citation xml:lang="en">Yuan M., Tse G., Zhang Z., Han X., Wu W.K.K., Li G. et al. The incidence of atrial fibrillation with trastuzumab treatment: A systematic review and meta-analysis. Cardiovasc. Ther. 2018;36(6):e12475. DOI: 10.1111/1755-5922.12475.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wang S.Y., Long J.B., Hurria A., Owusu C., Steingart R.M., Gross C.P. et al. Cardiovascular events, early discontinuation of trastuzumab, and their impact on survival. Breast Cancer Res. Treat. 2014;146(2):411–419. DOI: 10.1007/s10549-014-3029-0.</mixed-citation><mixed-citation xml:lang="en">Wang S.Y., Long J.B., Hurria A., Owusu C., Steingart R.M., Gross C.P. et al. Cardiovascular events, early discontinuation of trastuzumab, and their impact on survival. Breast Cancer Res. Treat. 2014;146(2):411–419. DOI: 10.1007/s10549-014-3029-0.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Farmakis D., Parissis J., Filippatos G. Insights into onco-cardiology: atrial fibrillation in cancer. JACC. 2014;63(10):945–953. DOI: 10.1016/j.jacc.2013.11.026.</mixed-citation><mixed-citation xml:lang="en">Farmakis D., Parissis J., Filippatos G. Insights into onco-cardiology: atrial fibrillation in cancer. JACC. 2014;63(10):945–953. DOI: 10.1016/j.jacc.2013.11.026.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Lenihan D.J., Kowey P.R. Overview and management of cardiac adverse events associated with tyrosine kinase inhibitors. Oncologist. 2013;18(8):900–908. DOI: 10.1634/theoncologist.2012-0466.</mixed-citation><mixed-citation xml:lang="en">Lenihan D.J., Kowey P.R. Overview and management of cardiac adverse events associated with tyrosine kinase inhibitors. Oncologist. 2013;18(8):900–908. DOI: 10.1634/theoncologist.2012-0466.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Veronese P., Hachul D., Scanavacca M., Hajjar L., Wu T., Sacilotto L. et al. Effects of anthracycline, cyclophosphamide and taxane chemotherapy on QTc measurements in patients with breast cancer. PLoS One. 2018;13(5):e0196763. DOI: 10.1371/journal.pone.0196763.</mixed-citation><mixed-citation xml:lang="en">Veronese P., Hachul D., Scanavacca M., Hajjar L., Wu T., Sacilotto L. et al. Effects of anthracycline, cyclophosphamide and taxane chemotherapy on QTc measurements in patients with breast cancer. PLoS One. 2018;13(5):e0196763. DOI: 10.1371/journal.pone.0196763.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y., Liu Y., Fan Z.W., Li J., Xu G.G. Meta-analysis of the risks of hypertension and QTc prolongation in patients with advanced non-small cell lung cancer who were receiving vandetanib. Eur. J. Clin. Pharmacol. 2015;71(5):541–547. DOI: 10.1007/s00228-015-1831-1.</mixed-citation><mixed-citation xml:lang="en">Liu Y., Liu Y., Fan Z.W., Li J., Xu G.G. Meta-analysis of the risks of hypertension and QTc prolongation in patients with advanced non-small cell lung cancer who were receiving vandetanib. Eur. J. Clin. Pharmacol. 2015;71(5):541–547. DOI: 10.1007/s00228-015-1831-1.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Han J.Y., Lee S.H., Lee G.K., Yun T., Lee Y.J., Hwang K.H. et al. Phase I/II study of gefitinib (IressaR) and vorinostat (IVORI) in previously treated patients with advanced non-small cell lung cancer. Cancer Chemother. Pharmacol. 2015;75(3):475–483. DOI: 10.1007/s00280-014-2664-9.</mixed-citation><mixed-citation xml:lang="en">Han J.Y., Lee S.H., Lee G.K., Yun T., Lee Y.J., Hwang K.H. et al. Phase I/II study of gefitinib (IressaR) and vorinostat (IVORI) in previously treated patients with advanced non-small cell lung cancer. Cancer Chemother. Pharmacol. 2015;75(3):475–483. DOI: 10.1007/s00280-014-2664-9.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">O’Connor O.A., Horwitz S., Masszi T., Van Hoof A., Brown P., Doorduijn J. et al. Belinostat in patients with relapsed or refractoryperipheral T-cell lymphoma: results of the pivotal phase II BELIEF (CLN-19) Study. J. Clin. Oncol. 2015;33(23):2492–2499. DOI: 10.1200/JCO.2014.59.2782.</mixed-citation><mixed-citation xml:lang="en">O’Connor O.A., Horwitz S., Masszi T., Van Hoof A., Brown P., Doorduijn J. et al. Belinostat in patients with relapsed or refractoryperipheral T-cell lymphoma: results of the pivotal phase II BELIEF (CLN-19) Study. J. Clin. Oncol. 2015;33(23):2492–2499. DOI: 10.1200/JCO.2014.59.2782.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Tisdale J. Drug-induced QT interval prolongation and torsades de pointes: role of the pharmacist in risk assessment, prevention and management. Can. Pharm. J. (Ott). 2016;149(3):139–152. DOI: 10.1177/1715163516641136.</mixed-citation><mixed-citation xml:lang="en">Tisdale J. Drug-induced QT interval prolongation and torsades de pointes: role of the pharmacist in risk assessment, prevention and management. Can. Pharm. J. (Ott). 2016;149(3):139–152. DOI: 10.1177/1715163516641136.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Porta-Sanchez A., Gilbert C., Spears D., Amir E., Chan J., Nanthakumar K. et al. Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review. J. Am. Heart Assoc. 2017;6(12):e07724. DOI: 10.1161/JAHA.117.007724.</mixed-citation><mixed-citation xml:lang="en">Porta-Sanchez A., Gilbert C., Spears D., Amir E., Chan J., Nanthakumar K. et al. Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer  Therapies: A Systematic Review. J. Am. Heart Assoc. 2017;6(12):e07724. DOI: 10.1161/JAHA.117.007724.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Fradley M., Viganego F., Kip K., Martin A., Patel A., Ismail-Khan R. et al. Rates and risk of arrhythmias in cancer survivors with chemotherapy-induced cardiomyopathy compared with patients with other cardiomyopathies. Open Heart. 2017;4(2):e000701. DOI: 10.1136/openhrt-2017-000701.</mixed-citation><mixed-citation xml:lang="en">Fradley M., Viganego F., Kip K., Martin A., Patel A., Ismail-Khan R. et al. Rates and risk of arrhythmias in cancer survivors with chemotherapy-induced cardiomyopathy compared with patients with other cardiomyopathies. Open Heart. 2017;4(2):e000701. DOI: 10.1136/openhrt-2017-000701.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kilickap S., Barista I., Akgul E., Ytemir K., Aksoy S., Tekuzman G. Early and late arrhythmogenic effects of doxorubicin. South. Med. J. 2007;100:262–265. DOI: 10.1097/01.smj.0000257382.89910.fe.</mixed-citation><mixed-citation xml:lang="en">Kilickap S., Barista I., Akgul E., Ytemir K., Aksoy S., Tekuzman G. Early and late arrhythmogenic effects of doxorubicin. South. Med. J. 2007;100:262–265. DOI: 10.1097/01.smj.0000257382.89910.fe.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lynch D., Washam J., Newby L. QT interval prolongation and torsades de pointes in a patient undergoing treatment with vorinostat: a case report and review of the literature. Cardiol. J. 2012;19(4):434–438.</mixed-citation><mixed-citation xml:lang="en">Lynch D., Washam J., Newby L. QT interval prolongation and torsades de pointes in a patient undergoing treatment with vorinostat: a case report and review of the literature. Cardiol. J. 2012;19(4):434–438.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Rowinsky E., Eisenhauer E., Chaudhry V., Arbuck S.G., Donehower R. Clinical toxicities encountered with paclitaxel (Taxol). Semin. Oncol. 1993;20(4):1–15.</mixed-citation><mixed-citation xml:lang="en">Rowinsky E., Eisenhauer E., Chaudhry V., Arbuck S.G., Donehower R. Clinical toxicities encountered with paclitaxel (Taxol). Semin. Oncol. 1993;20(4):1–15.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Osman M., Elkady M. A Prospective Study to Evaluate the Effect of Paclitaxel on Cardiac Ejection Fraction. Breast Care. 2017;12(4):255–259. DOI: 10.1159/000471759.</mixed-citation><mixed-citation xml:lang="en">Osman M., Elkady M. A Prospective Study to Evaluate the Effect of Paclitaxel on Cardiac Ejection Fraction. Breast Care. 2017;12(4):255–259. DOI: 10.1159/000471759.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Wheeler D., Liew T., Bailey A. Peri-operative atrioventricular block as a result of chemotherapy with epirubicin and paclitaxel. Anaesthesia. 2007;62(2):186–189. DOI: 10.1111/j.1365-2044.2006.04946.x.</mixed-citation><mixed-citation xml:lang="en">Wheeler D., Liew T., Bailey A. Peri-operative atrioventricular block as a result of chemotherapy with epirubicin and paclitaxel. Anaesthesia. 2007;62(2):186–189. DOI: 10.1111/j.1365-2044.2006.04946.x.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Katsume Y., Isawa T., Toi Y., Fukuda R., Kondo Y., Sugawara S. et al. Complete atrioventricular block associated with pembrolizumab-induced acute myocarditis: the need for close cardiac monitoring. Intern. Med. 2018;57(21):3157–3162. DOI: 10.2169/internalmedicine.0255-17.</mixed-citation><mixed-citation xml:lang="en">Katsume Y., Isawa T., Toi Y., Fukuda R., Kondo Y., Sugawara S. et al. Complete  atrioventricular block associated with pembrolizumab-induced acute myocarditis: the need for close cardiac monitoring. Intern. Med. 2018;57(21):3157–3162. DOI: 10.2169/internalmedicine.0255-17.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Moses H., Matheson D.H., Cairns-Smith S., George B.P., Palisch C., Dorsey E.R. The anatomy of medical research: US and international comparisons. JAMA. 2015;313(2):174–189. DOI: 10.1001/jama.2014.15939.</mixed-citation><mixed-citation xml:lang="en">Moses H., Matheson D.H., Cairns-Smith S., George B.P., Palisch C., Dorsey E.R. The anatomy of medical research: US and international comparisons. JAMA. 2015;313(2):174–189. DOI: 10.1001/jama.2014.15939.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ferri N., Siegl P., Corsini A., Нerrmann J., Lerman A., Benghozi R. Drug attrition during pre-clinical and clinical development: understanding and managing drug-induced cardiotoxicity. Pharmacol. Ther. 2013;138(3):470–484. DOI: 10.1016/j.pharmthera.2013.03.005.</mixed-citation><mixed-citation xml:lang="en">Ferri N., Siegl P., Corsini A., Нerrmann J., Lerman A., Benghozi R. Drug attrition during pre-clinical and clinical development: understanding and managing drug-induced cardiotoxicity. Pharmacol. Ther. 2013;138(3):470–484. DOI: 10.1016/j.pharmthera.2013.03.005.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Fleissig A.J.V., Jenkins V., Catt S., Fallowfield L. Multidisciplinary teams in cancer care: are they effective in the UK. Lancet Oncol. 2006;7:935–943. DOI: 10.1016/S1470-2045(06)70940-8.</mixed-citation><mixed-citation xml:lang="en">Fleissig A.J.V., Jenkins V., Catt S., Fallowfield L. Multidisciplinary teams in cancer care: are they effective in the UK. Lancet Oncol. 2006;7:935–943. DOI: 10.1016/S1470-2045(06)70940-8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
