Preview

Siberian Journal of Clinical and Experimental Medicine

Advanced search

Predictors of early adverse events after ascending aortic replacement

https://doi.org/10.29001/2073-8552-2022-37-1-108-117

Abstract

Objective. The aim of this study was to identify predictors of adverse events after ascending aortic replacement for the aortic aneurysms in the early postoperative period.

Material and Methods. The analysis included 151 patients with ascending aortic aneurysm who underwent non-hemiarch or hemiarch repair. The following adverse outcomes were selected: postoperative delirium, respiratory failure, bleeding, multiple organ dysfunction syndrome, and in-hospital mortality. Predictors of adverse clinical events were identified by constructing uni- and multivariate logistic regression.

Results. Significant predictors of early outcomes and mortality after ascending aortic replacement were as follows: female gender, atrial fibrillation, low glomerular filtration rate, chronic obstructive pulmonary disease, aortic root repair, multiple organ dysfunction, duration of cardiac arrest, operation time, and reoperation for bleeding.

Conclusions. The risk factors of adverse outcomes after ascending aortic replacement were decreased kidney function, atrial fibrillation, female gender, aortic root repair, and increased duration of cardiac arrest and operation time. 

About the Authors

B. N. Kozlov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation

Dr. Sci. (Med.), Head of the Department of Cardiovascular Surgery, 

111a, Kievskaya str., Tomsk, 634012



D. S. Panfilov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation

Dr. Sci. (Med.), Senior Research Scientist,

111a, Kievskaya str., Tomsk, 634012



E. L. Sonduev
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation

Cardiovascular Surgeon, 

111a, Kievskaya str., Tomsk, 634012



V. L. Lukinov
Institute of Computational Mathematics and Mathematical Geophysics of the Siberian Branch of the Russian Academy of Sciences
Russian Federation

Cand. Sci. (Phys.-Math.), Senior Research Scientist,

6, Ac. Lavrentieva ave., Novosibirsk, 630090



References

1. Yan T.D., Bannon P.G., Bavaria J., Coselli J.S., Elefteriades J.A., Griepp R.B. et al. Consensus on hypothermia in aortic arch surgery. Ann. Cardiothorac. Surg. 2013;2(2):163–168. DOI: 10.3978/j.issn.2225-319X.2013.03.03.

2. Davies R.A., Black D., Jeremy R.W., Bannon P.G., Bayfield M.S., Hendel P.N. et al. Evolution in the techniques and outcomes of aortic arch surgery: А 22 year single centre experience. Heart Lung Circ. 2011;20(11):704–711. DOI: 10.1016/j.hlc.2011.07.009.

3. Williams J.B., Peterson E.D., Zhao Y., O‘Brien S.M., Andersen N.D., Miller D.C. et al. Contemporary results for proximal aortic replacement in North America. J. Am. Coll. Cardiol. 2012;60(13):1156–1162. DOI: 10.1016/j.jacc.2012.06.023.

4. Kozlov B.N., Panfilov D.S., Sonduev E.L., Lukinov V.L. Ascending aortic aneurysm: Propensity score matching analysis of hemiarch and non-hemiarch replacement. Russian Journal of Cardiology. 2020;25(10):3887. (In Russ.). DOI: 10.15829/1560-4071-2020-3887.

5. Indja B., Fanning J.P., Maller J.J., Fraser J.F., Bannon P.G., Vallely M. et al. Neural network imaging to characterize brain injury in cardiac procedures: The emerging utility of connectomics. Br. J. Anaesth. 2017;118(5):680–688. DOI: 10.1093/bja/aex088.

6. Wagner M.A., Wang H., Benrashid E., Keenan J.E., Ganapathi A.M., Englum B.R. et al. Risk рrediction model for major adverse outcome in proximal thoracic aortic surgery. Ann. Thorac. Surg. 2019;107(3):795– 801. DOI: 10.1016/j.athoracsur.2018.09.052.

7. Otomo S., Maekawa K., Baba T., Goto T., Yamamoto T. Evaluation of the risk factors for neurological and neurocognitive impairment after selective cerebral perfusion in thoracic aortic surgery. J. Anesth. 2020;34(4):527–536. DOI: 10.1007/s00540-020-02783-x.

8. Kozlov B.N., Panfilov D.S., Lukinov V.L. Predictors of early adverse events after the frozen elephant trunk procedure. Angiology and Vascular Surgery. 2021;27(4);94–102. (In Russ.). DOI: 10.33529/ANGIO2021413.

9. Kamiya H., Hagl C., Kropivnitskaya I., Böthig D., Kallenbach K., Khaladj N. et al. The safety of moderate hypothermic lower body circulatory arrest with selective cerebral perfusion: А propensity score analysis. J. Thorac. Cardiovasc. Surg. 2007;133(2):501–509. DOI: 10.1016/j.jtcvs.2006.09.045.

10. Tian D.H., Wan B., Bannon P.G., Misfeld M., LeMaire S.A., Kazui T. et al. A meta-analysis of deep hypothermic circulatory arrest versus moderate hypothermic circulatory arrest with selective antegrade cerebral perfusion. Ann. Cardiothorac. Surg. 2013;2(2):148–158. DOI: 10.3978/j.issn.2225-319X.2013.03.13.

11. Harrington D.K., Lilley J.P., Rooney S.J., Bonser R.S. Nonneurologic morbidity and profound hypothermia in aortic surgery. Ann. Thorac Surg. 2004;78(2):596–601. DOI: 10.1016/j.athoracsur.2004.01.012.

12. Leontyev S., Davierwala P.M., Semenov M., von Aspern K., Krog G., Noack T. et al. Antegrade selective cerebral perfusion reduced in-hospital mortality and permanent focal neurological deficit in patients with elective aortic arch surgery. Eur. J. Cardiothorac. Surg. 2019;56(5):1001– 1008. DOI: 10.1093/ejcts/ezz091.

13. Ghincea C.V., Reece T.B., Eldeiry M., Roda G.F., Bronsert M.R., Jarrett M.J.et al. Predictors of аcute kidney injury following aortic arch surgery. J. Surg. Res. 2019;242:40–46. DOI: 10.1016/j.jss.2019.03.055.

14. Apaydin A.Z., Islamoglu F., Posacioglu H., Yagdi T., Atay Y., Calkavur T. et al. Clinical outcomes in “complex” thoracic aortic surgery. Tex. Heart Inst. J. 2007;34(3):301–304.

15. Kamenskaya O.V., Klinkova A.S., Loginova I.Yu., Chernyavsky A.M., Lomivorotov V.V., Karaskov A.M. Factors which influence the quality of life after surgical treatment of the dissection of ascending aorta and aortic arch. Russian Journal of Cardiology. 2018;23(11):14–20. (In Russ.). DOI: 10.15829/1560-4071-2018-11-14-20.

16. Chung J., Stevens L.M., Ouzounian M., El-Hamamsy I., Bouhout I., Dagenais F. et al. Sex-related differences in patients undergoing thoracic aortic surgery. Circulation. 2019;139(9):1177–1184. DOI: 10.1161/CIRCULATIONAHA.118.035805.

17. Brown J.M., O’Brien S.M., Wu C., Sikora J.A., Griffith B.P., Gammie J.S. Isolated aortic valve replacement in North America comprising 108,687 patients in 10 years: changes in risks, valve types, and outcomes in the Society of Thoracic Surgeons National Database. J. Thorac. Cardiovasc. Surg. 2009;137(1):82–90. DOI: 10.1016/j.jtcvs.2008.08.015.

18. Ambler G., Omar R.Z., Royston P., Kinsman R., Keogh B.E., Taylor K.M. Generic, simple risk stratification model for heart valve surgery. Circulation. 2005;112(2):224–231. DOI: 10.1161/CIRCULATIONAHA.104.515049.

19. Belov Yu.V., Gerasimov A.N., Charchyan E.R., Komarov R.N., Vikent’yev V.V., Alekseev I.A. et al. EuroSCORE model ARCH: Prognosis of perioperative risk factors in aortic arch surgery with cerebral protection. Russian Journal of Cardiology and Cardiovascular Surgery. 2015;8(4):17– 25. (In Russ.). DOI: 10.17116/kardio20158417-25.

20. Ganapathi A.M., Englum B.R., Hanna J.M., Schechter M.A., Gaca J.G., Hurwitz L.M. et al. Frailty and risk in proximal aortic surgery. J. Thorac. Cardiovasc. Surg. 2014;147(1):186–191. DOI: 10.1016/j.jtcvs.2013.09.011.


Review

For citations:


Kozlov B.N., Panfilov D.S., Sonduev E.L., Lukinov V.L. Predictors of early adverse events after ascending aortic replacement. Siberian Journal of Clinical and Experimental Medicine. 2022;37(1):108-117. (In Russ.) https://doi.org/10.29001/2073-8552-2022-37-1-108-117

Views: 605


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2713-2927 (Print)
ISSN 2713-265X (Online)