Gender-specific differences in ascending aortic surgery
https://doi.org/10.29001/2073-8552-2022-37-3-108-113
Abstract
Introduction. According to recent data, thoracic aortic surgery have reduced morbidity and mortality, however, women are at increased postoperative risk of adverse outcomes. Our aim was to evaluate and compare early outcomes in male and female patients undergoing ascending aortic replacement.
Methods. A total of 88 patients, consisting of 54 men (61.4%) and 34 women (38.6%) underwent ascending aortic surgery for non-syndromic aneurysms from January 2013 to December 2021. We analyzed clinical outcomes between males and females.
Results. According to computed tomographic angiography, preoperative normalized aortic diameters were significantly larger in females (2.9 [2.7; 3.2] cm/m2) vs. (2.5 [2.3; 2.6] cm/m2, p < 0.001) in males, without differences in absolute values (51 [49; 53] mm vs. 52 [50; 53] mm, p = 0.356). There were no significant differences in neurological, cardiac, pulmonary, and renal complications in both groups in the early postoperative period. In-hospital mortality was 1.9% and 5.9% (p = 0.307) in male and female patients, respectively.
Conclusions. Ascending aortic surgery for aneurysms below 5.5 cm threshold has tolerable early outcomes both in men and women.
About the Authors
D. S. PanfilovRussian Federation
Dmitri S. Panfilov, Dr. Sci. (Med.), Senior Research Scientist
111a, Kievskaya str., Tomsk, 634012
V. V. Saushkin
Russian Federation
Viktor V. Saushkin, Cand. Sci. (Med.), Senior Research Scientist
111a, Kievskaya str., Tomsk, 634012
E. L. Sonduev
Russian Federation
Erdeni L. Sonduev, Cardiovascular Surgeon
111a, Kievskaya str., Tomsk, 634012
S. I. Sazonova
Russian Federation
Svetlana I. Sazonova, Dr. Sci. (Med.), Senior Research Scientist
111a, Kievskaya str., Tomsk, 634012
B. N. Kozlov
Russian Federation
Boris N. Kozlov, Dr. Sci. (Med.), Head of the Department of Cardiovascular Surgery
111a, Kievskaya str., Tomsk, 634012
References
1. Saeyeldin A., Zafar M.A., Li Y., Tanweer M., Abdelbaky M., Gryaznov A. et al. Decision-making algorithm for ascending aortic aneurysm: Eff ectiveness in clinical application? J. Thorac. Cardiovasc. Surg. 2019;157(5):1733–1745. DOI: 10.1016/j.jtcvs.2018.09.124.
2. Friedrich C., Freundt M., Salem M.A., Panholzer B., Huenges K., Puehler T. et al. Sex-specifi c outcome after ascending aortic surgery in moderate hypothermic circulatory arrest. Thorac. Cardiovasc. Surg. 2021;69(4):314–321. DOI: 10.1055/s-0039-1698409.
3. Chung J., Stevens L-M., Ouzounian M., El-Hamamsy I., Bouhout I., Dagenais F. et al. Sex-related diff erences in patients undergoing thoracic aortic surgery. Circulation. 2019;139:1177–1184. DOI: 10.1161/CIRCULATIONAHA.118.035805.
4. Chung J., Coutinho T., Chu M.W.A., Ouzounian M. Sex diff erences in thoracic aortic disease: A review of the literature and a call to action. J. Thorac. Cardiovasc. Surg. 2020;160(3):656–660. DOI: 10.1016/j.jtcvs.2019.09.194.
5. Kozlov B.N., Panfi lov D.S., Zherbakhanov A.V., Khodashinsky I.A., Sonduev É.L. Early results of various surgical approaches in reconstruction of ascending aortic aneurysms. Angiology and Vascular Surgery. 2019;25(3):101–106. (In Russ.) DOI: 10.33529/ANGIO2019310.
6. Lo R.C., Bensley R.P., Hamdan A.D., Wyers M., Adams J.E., Schermerhorn M.L. Gender diff erences in abdominal aortic aneurysm presentation, repair, and mortality in the Vascular Study Group of New England. J. Vasc. Surg. 2013;57(5):1261–1268. DOI: 10.1016/j.jvs.2012.11.039.
7. Erbel R., Aboyans V., Boileau C., Bossone E., Di Bartolomeo R., Eggebrecht H. et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases. Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur. Heart J. 2014;35:2873–2926. DOI: 10.1093/eurheartj/ehu281.
8. Elefteriades J.A. Natural history of thoracic aortic aneurysms: indications for surgery, and surgical versus nonsurgical risks. Ann. Thorac. Surg. 2002;74(5):1877–1880; discussion 1892–1898. DOI: 10.1016/s0003-4975(02)04147-4.
9. Davies R.R., Gallo A., Coady M.A., Tellides G., Botta D.M., Burke B. et al. Novel measurement of relative aortic size predicts rupture of thoracic aortic aneurysms. Ann. Thorac. Surg. 2006;81(1):169–177. DOI: 10.1016/j.athoracsur.2005.06.026.
10. Cheung K., Boodhwani M., Chan K-L., Beauchesne L., Dick A., Coutinho T. Thoracic aortic aneurysm growth: role of sex and aneurysm etiology. J. Am. Heart Assoc. 2017;6:e003792. DOI: 10.1161/JAHA.116.003792.
11. Sokolis D.P., Iliopoulos D.C. Impaired mechanics and matrix metalloproteinases/inhibitors expression in female ascending thoracic aortic aneurysms. J. Mech. Behav. Biomed. Mater. 2014;34:154–164. DOI: 10.1016/j.jmbbm.2014.02.015.
12. Schuster V., Eggersmann T.K., Eifert S., Ueberfuhr P., Zugenmaier B., Kolben T.M. et al. Ascending aortic disease is associated with earlier menopause and shorter reproductive life span. J. Womens Health (Larchmt.). 2016;25(9):912–919. DOI: 10.1089/jwh.2015.5559.
13. Hannawa K.K., Eliason J.L., Upchurch G.R. Jr. Gender diff erences in abdominal aortic aneurysms. Vascular. 2009;17(1):30–39. DOI: 10.2310/6670.2008.00092.
14. Beller C.J., Farag M., Wannaku S., Seppelt P., Arif R., Ruhparwar A. et al. Gender-specifi c diff erences in outcome of ascending aortic aneurysm surgery. PLoS One. 2015;10(4):e0124461. DOI: 10.1371/journal.pone.0124461.
15. Tsagakis K., Pacini D., Grabenwöger M., Borger M.A., Goebel N., Hemmer W. et al. Results of frozen elephant trunk from the international E-vita Open registry. Ann. Cardiothorac. Surg. 2020;9(3):178–188. DOI: 10.21037/acs-2020-fet-25.
16. Zafar M.A., Li Y., Rizzo J.A., Charilaou P., Saeyeldin A., Velasquez C.A. et al. Height alone, rather than body surface area, suffi ces for risk estimation in ascending aortic aneurysm. J. Thorac. Cardiovasc. Surg. 2018;155(5):1938–1950. DOI: 10.1016/j.jtcvs.2017.10.140.
17. Ziganshin B.A., Zafar M.A., Elefteriades J.A. Descending threshold for ascending aortic aneurysmectomy: Is it time for a ‘‘left-shift’’ in guidelines? J. Thorac. Cardiovasc. Surg. 2019;157(1):37–42. DOI: 10.1016/j.jtcvs.2018.07.114.
18. Bons L.R., Rueda-Ochoa O.L., Ghoul K.E., Rohde S., Budde R.P. Leening M.J. et al. Sex-specifi c distributions and determinants of thoracic aortic diameters in the elderly. Heart. 2020;106(2):133–139. DOI: 10.1136/heartjnl-2019-315320.
19. Lodewyks C.L., Prior H.J., Hiebert B.M., Nickel N.C., Yamashita M.H., Ouzounian M. et al. A Province-wide analysis of the epidemiology of thoracic aortic disease: Incidence is increasing in a sex-specifi c way. Can. J. Cardiol. 2020;36(11):1729–1738. DOI: 10.1016/j.cjca.2019.11.013.
Review
For citations:
Panfilov D.S., Saushkin V.V., Sonduev E.L., Sazonova S.I., Kozlov B.N. Gender-specific differences in ascending aortic surgery. Siberian Journal of Clinical and Experimental Medicine. 2022;37(3):108-113. (In Russ.) https://doi.org/10.29001/2073-8552-2022-37-3-108-113