Opioid receptor agonists to prevent heart reperfusion injury: analysis of experimental and clinical data
https://doi.org/10.29001/2073-8552-2015-30-2-36-39
Abstract
In Russia, in-hospital lethality after acute myocardial infarction is 13.8%. The part of patients perishes even after recanalization of the infarct-related coronary artery as a result of myocardial reperfusion injury. Experimental data indicate that opioid receptor agonists can prevent reperfusion damage of the heart mimicking postconditioning phenomena. Agonists of k1-and δ2-opioid receptors exhibit the most pronounced infarct-limiting effects. Clinical data indicate that morphine is able to prevent cardiac reperfusion injury in humans. Therefore, the analysis of published data suggests that opioid receptor agonists can be prototype for development of drugs for prophylaxis of reperfusion heart injury.
About the Authors
L. N. Maslov
Federal State Budgetary Scientific Institution "Research Institute for Cardiology"
Russian Federation
Russian Federation
S. Yu. Tsibulnikov
Federal State Budgetary Scientific Institution "Research Institute for Cardiology"
Russian Federation
Russian Federation
A. V. Mukhomedzyanov
Federal State Budgetary Scientific Institution "Research Institute for Cardiology"
Russian Federation
Russian Federation
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Review
For citations:
Maslov L.N., Tsibulnikov S.Yu., Mukhomedzyanov A.V. Opioid receptor agonists to prevent heart reperfusion injury: analysis of experimental and clinical data. Siberian Journal of Clinical and Experimental Medicine. 2015;30(2):36-39. (In Russ.) https://doi.org/10.29001/2073-8552-2015-30-2-36-39
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