Magnetic resonance imaging with paramagnetic contrast enhancement as a tool for the control of antiatherosclerotic treatment with atorvastatine in case of carotid stenosis
https://doi.org/10.29001/2073-8552-2015-30-2-96-101
Abstract
The article presents and discusses capabilities of magnetic resonance imaging with paramagnetic contrast enhancement as a possible tool for long-term follow-up of atherosclerotic plaques. Authors present a case of following-up a patient with bilateral carotid atherosclerotic plaques treated with atorvastatine at a dose of 40 mg per day for as long as two years. Data suggest that long-term treatment with atorvastatine is associated with decrease in contrast enhancement of atherosclerotic plaques of carotid arteries and also with stabilization/improvement in MRI scans of the brain itself.
About the Authors
E. E. Bobrikova
Federal State Budgetary Scientific Institution "Research Institute for Cardiology"
Russian Federation
Russian Federation
A. S. Maksimova
Federal State Budgetary Scientific Institution "Research Institute for Cardiology"
Russian Federation
Russian Federation
P. I. Lukyanenok
Federal State Budgetary Scientific Institution "Research Institute for Cardiology"
Russian Federation
Russian Federation
V. D. Aptekar
Federal State Budgetary Scientific Institution "Research Institute for Cardiology"
Russian Federation
Russian Federation
M. P. Plotnikov
Federal State Budgetary Scientific Institution "Research Institute for Cardiology"
Russian Federation
Russian Federation
A. M. Gusakova
Federal State Budgetary Scientific Institution "Research Institute for Cardiology"
Russian Federation
Russian Federation
W. Yu. Ussov
Federal State Budgetary Scientific Institution "Research Institute for Cardiology"
Russian Federation
Russian Federation
References
1. Бобрикова Е.Э., Щербань Н.В., Ханеев В.Б. и др. Оценка состояния атеросклеротических бляшек брахиоцефальных артерий средствами высокоразрешающей контрастированной МРТ: взаимосвязь с ишемичсским повреждением головного мозга // Мед. визуализация. - 2013. - № 1. - С. 26-34.
2. Amarenco P., Labreuche J., Lavallere P., Touboul P.-J. Statin in stroke prevention and carotid atherosclerosis: systematic review and meta-analysis // Stroke. - 2004. - Vol. 35. - P. 2902-2909.
3. Benavente O., Moher D., Pham B. Carotid endarterectomy for asymptomatic carotid stenosis: a meta-analysis // BMJ. - 1998. - Vol. 317. - P. 1477-1480.
4. Choudhury R.P., Fuster V., Badimon J.J. et al. MRI and characterization of atherosclerotic plaque: emerging applications and molecular imaging // Arteriosclerosis, Thrombosis, and Vascular Biology. - 2002. - Vol. 22, No. 7. -P. 1065-1074.
5. De Boer O.J., Van Der Wal A.C., Teeling P. et al. Leucocyte recruitment in rupture prone regions of lipid-rich plaques: a prominent role for neovascularization // Cardiovascular Research. - 1999. - Vol. 41, No. 2. - P. 443-449.
6. Fayad Z.A., Fuster V., Fallon J.T. et al. Noninvasive in vivo human coronary artery lumen and wall imaging using black-blood magnetic resonance imaging // Circulation. - 2000. - Vol. 102, No. 5. - P. 506-510.
7. Fayad Z.A., Sirol M., Moreno P.R. et al. Increased neovascularization in advanced lipid-rich atherosclerotic lesions detected by gadofluorine-m-enhanced MRI: implications for plaque vulnerability // Circulation. - 2009. - Vol. 2, No. 5. -P. 391-396.
8. Gresser U., Gathof B.S. Atorvastatin: gold standard for prophylaxis myocardial ischemia and stroke // Eur. J. Med. Res. - 2004. - Vol. 9. - P. 1-17.
9. Gronholdt M.L. B-mode ultrasound and spiral CT for the assessment of carotid atherosclerosis // Neuroimaging Clin. N. Am. - 2002. - No. 12(3). - P. 421-435.
10. Jiang X.B., Yuan W.S., Wang J.S. et al. Matrix metalloproteinase-9 expression in carotid atherosclerotic plaque and contrast-enhanced MRI in a swine model // Journal of Neurointerventional Surgery. - 2014. - Vol. 6, No. 1. - P. 24-28.
11. Moreno P., Purushothaman K.R., Fuster V. et al. Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability // Circulation. - 2004. - Vol. 110, No. 14. - P. 2032-2038.
12. Moreno P.R., Purushothaman K.-R., Sirol M. et al. Neovascularization in human atherosclerosis // Circulation. - 2006. - Vol. 113, No. 18. - P. 2245-2252.
13. Murphy S.L., Xu J., Kochanek K.D. Deaths: preliminary data for 2010 // National Vital Statistics Reports. - 2012. - Vol. 60, No. 4. - P. 1-51.
14. Reith W. Extracranial carotid stenosis: diagnostics, therapy and follow-up // Radiologe. - 2013. - No. 53(6). - P. 545-560.
15. Szapary L., Horvath B., Marton Z. et al. Short-term effect of lowdose atorvastatin on haemorrheological parameters, platelet aggregation and endothelial function in patients with cerebrovascular disease and hyperlipidaemia // CNS Drugs. -2004. - Vol. 18. - P. 165-172.
16. Virmani R., Kolodgie F.D., Burke A.P. et al. Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage // Arteriosclerosis, Thrombosis, and Vascular Biology. - 2005. - Vol. 25, No. 10. -P. 2054-2061.
17. Wagenknecht L., Wasserman B., Chambless L. et al. Correlates of carotid plaque presence and composition as measured by mri the atherosclerosis risk in communities study // Circulation. -2009. - Vol. 2, No. 4, - P. 314-322.
18. Wagner S., Schnorr J., Ludwig A. et al. Contrast-enhanced MR imaging of atherosclerosis using citrate-coated superparamagnetic iron oxide nanoparticles: calcifying microvesicles as imaging target for plaque characterization // International Journal of Nanomedicine. - 2013. - Vol. 8. -P. 767-779.
19. Wasserman B.A., Sharrett A.R., Lai S. et al. Risk factor associations with the presence of a lipid core in carotid plaque of asymptomatic individuals using high-resolution MRI: the Multi-Ethnic Study of Atherosclerosis (MESA) // Stroke. - 2008. -Vol. 39, No. 2. - P. 329-335.
20. World Health Organization, Cardiovascular diseases (CVDs) // Fact Sheet. - 2011. - No. 317.
21. Yuan C., Lin E., Millard J. et al. Closed contour edge detection of blood vessel lumen and outer wall boundaries in black-blood MR images // Magnetic Resonance Imaging. - 1999. - Vol. 17, No. 2. - P. 257-266.
22. Zhao Li, X., Liu X. et al. Evaluation of the early enhancement of coronary atherosclerotic plaque by contrast-enhanced MR angiography // European Journal of Radiology. - 2011. -Vol. 80, No. 1. - P. 136-142.
Review
For citations:
Bobrikova E.E., Maksimova A.S., Lukyanenok P.I., Aptekar V.D., Plotnikov M.P., Gusakova A.M., Ussov W.Yu. Magnetic resonance imaging with paramagnetic contrast enhancement as a tool for the control of antiatherosclerotic treatment with atorvastatine in case of carotid stenosis. Siberian Journal of Clinical and Experimental Medicine. 2015;30(2):96-101. (In Russ.) https://doi.org/10.29001/2073-8552-2015-30-2-96-101
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