Radiation phenotypes of chronic obstructive pulmonary disease in patients with type 2 diabetes mellitus
https://doi.org/10.29001/2073-8552-2022-608
Abstract
The relevance of the work is due to the lack of systematic data on the features of lung damage in patients with chronic obstructive pulmonary disease (COPD) and type II diabetes mellitus (DM2).
Aim: To identify the main radiation phenotypes of lung tissue damage in patients with chronic obstructive pulmonary disease and type II diabetes mellitus.
Material and Methods. We conducted a one-stage observational study, with the analysis of clinical data, laboratory and instrumental studies (pulmonary function tests, computed tomography), in patients with chronic obstructive pulmonary disease in combination with type II diabetes mellitus (57 people).
Results. In patients with a combination of COPD and type II diabetes mellitus, the predominance of predominantly bronchitic type of COPD over emphysematous was revealed, with the presence of statistically significant links between a number of patterns (the presence of air trapping, bronchiolitis) and laboratory results (the number of eosinophils in the blood, the number of leukocytes in the blood and sputum, the number of macrophages in sputum, levels of IL-33, TNF-α, CRP, IFN-γ/IL-4 ratio), which may reflect the influence of different pathogenetic aspects of inflammation on the formation of structural changes in the lung tissue).
Conclusion. For patients with a combination of chronic obstructive pulmonary disease and type II diabetes mellitus, the presence of a bronchitic COPD phenotype with the absence of confluent and destructive forms of pulmonary emphysema is more characteristic. The wide prevalence of the bronchitic COPD phenotype in patients with concomitant type 2 diabetes mellitus may be due to predominant changes in the small airways, the development of microangiopathy, as well as an infectious factor, since patients with type 2 diabetes mellitus, in general, are more susceptible to infections, including respiratory.
About the Authors
A. S. Pavlova
Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation
Russian Federation
Russian Federation
Anastasia S. Pavlova, Graduate Student, Department of Hospital Therapy with the course of Allergology and Immunology named after Akad. M.V. Chernorutsky with the clinic
6-8, Lva Tolstogo str., St. Petersburg, 197022, Russian Federation
O. V. Lukina
Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation
Russian Federation
Russian Federation
Olga V. Lukina, Dr. Sci. (Med.), Associate Professor, Department of Radiology and Radiation Medicine with Radiological and Radiological Departments, Head of the Scientific and Clinical Center for Radiation Diagnostics
6-8, Lva Tolstogo str., St. Petersburg, 197022, Russian Federation
References
1. Tjurin I.E. Visualization of chronic obstructive pulmonary disease. Practical pulmonology. 2014;2:40–46. (In Russ.) URL: https://cyberleninka.ru/article/n/vizualizatsiya-hronicheskoy-obstruktivnoy-bolezni-legkih-1 (18.08.2023).
2. Kukol L.V., Archakova L.I., Molokova E.R. The main phenotypes of chronic obstructive pulmonary disease. Medical alliance. 2019;1:38–45. (In Russ.) URL: https://med-alyans.ru/index.php/Hahn/article/view/563/666 (18.08.2023).
3. Lukina O.V. Amosov V.I., Zolotnickaja V.P., Bugaev S.S., Gorbunkov S.D. Radiation diagnosis of circulatory disorders in patients with chronic obstructive pulmonary disease of various phenotypes. Diagnostic radiology and radiotherapy. 2013;4(4):88–94. (In Russ.)
4. Lee J.-H., Lee Y.K., Kim E.-K., Kim T.-H., Huh J.W., Kim W.J. et al. Responses to inhaled long-acting beta-agonist and corticosteroid according to COPD subtype. Respiratory medicine. 2010;104(4):542–549. DOI: 10.1016/j.rmed.2009.10.024.
5. Kauczor H.U., Wielpütz M.O., Owsijewitsch M., Ley-Zaporozhan J. Computed tomographic imaging of the airways in COPD and asthma. J. Thorac. Imaging. 2011;26(4):290–300. DOI: 10.1097/RTI.0b013e3182277113.
6. Camiciottoli G., Bigazzi F., Magni C., Bonti V., Diciotti S., Bartolucci M. et al. Prevalence of comorbidities according to predominant phenotype and severity of chronic obstructive pulmonary disease. Int. J. Chron. Obstruct. Pulmon. Dis. 2016;11:2229–2236. DOI: 10.2147/COPD.S111724.
7. Katsiki N., Steiropoulos P., Papanas N., Mikhailidis D.P. Diabetes mellitus and chronic obstructive pulmonary disease: an overview. Exp. Clin. Endocrinol. Diabetes. 2021;129(10):699–704. DOI: 10.1055/a-1038-3883.
8. Gläser S., Krüger S., Merkel M., Bramlage P., Herth F.J. Chronic obstructive pulmonary disease and diabetes mellitus: a systematic review of the literature. Respiration. 2015;89(3):253–264. DOI: 10.1159/000369863.
9. Pitocco D., Fuso L., Conte E.G., Zaccardi F., Condoluci C., Scavone G. et al. The diabetic lung – A new target organ? Rev. Diabet Stud. 2012;9(1):23–35. DOI: 10.1900/RDS.2012.9.23.
10. Peng Y., Zhong G.-C., Wang L., Guan L., Wang A., Hu K. et al. Chronic obstructive pulmonary disease, lung function and risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies. BMC Pulm. Med. 2020;20(1):137. DOI: 10.1186/s12890-020-1178-y.
11. Hersh C.P. Make B.J., Lynch D.A., Barr R.G., Bowler R.P., Calverley P.M.A. et al. Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulmonary Medicine. 2014;14:164. DOI: 10.1186/1471-2466-14-164.
12. Chuchalin A.G., Avdeev S.N., Aisanov Z.R., Belevskiy A.S., Leshchenko I.V., Ovcharenko S.I. et al. Federal guidelines on diagnosis and treatment of chronic obstructive pulmonary disease. Pulmonology. 2022;32(3):356–392. (In Russ.) DOI: 10.18093/0869-0189-2022-32-3-356-392.
13. Lynch D.A., Austin J.H., Hogg J.C., Grenier P.A., Kauczor H.U., Bankier A.A. et al. CT-definable subtypes of chronic obstructive pulmonary disease: A statement of the Fleischner Society. Radiology. 2015;277(1):192–205. DOI: 10.1148/radiol.2015141579.
14. Rogliani Р., Lucà G., Lauro D. Chronic obstructive pulmonary disease and diabetes. COPD Res. Pract. 2015;1:3. DOI: 10.1186/s40749-015-0005-y.
15. Shoikchet Y.N., Konovalov V.K., Saveljev S.G., Titova E.A., Dukov L.G., Gervalt V.Y. et al. Computed tomographic and histologic changes in lung in diabetes mellitus. Bjulleten SO RAMN. 2008;130(2):63–67. (In Russ.) URL: https://radiomed.ru/sites/default/files/59248635.pdf (18.08.2023).
16. Katsogiannos P., Kamble P.G., Pereira M.J., Sundbom M., Carlsson P.-O., Eriksson J.W. et al. Changes in circulating cytokines and adipokines after RYGB in patients with and without type 2 diabetes. Obesity (Silver Spring). 2021;29(3):535–542. DOI: 10.1002/oby.23093.
17. Suganami T., Tanimoto-Koyama K., Nishida J., Itoh M., Yuan X., Mizuarai S. et al. Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler. Thromb. Vasc. Biol. 2007:27(1):84–91. DOI: 10.1161/01.ATV.0000251608.09329.9a.
Review
For citations:
Pavlova A.S., Lukina O.V. Radiation phenotypes of chronic obstructive pulmonary disease in patients with type 2 diabetes mellitus. Siberian Journal of Clinical and Experimental Medicine. 2023;38(3):95-102. (In Russ.) https://doi.org/10.29001/2073-8552-2022-608
Views:
340
.png)
Email this article 