С-JUN N-TERMINAL KINASES AND THEIR MODULATORS IN MYOCARDIAL ISCHEMIA/REPERFUSION INJURY (REVIEW)
https://doi.org/10.29001/2073-8552-2016-31-3-7-15
Abstract
The article provides review of literature on the role of c Jun N terminal kinases (JNK) in ischemia/reperfusion injury of the myocardium. The classification of JNK is presented; JNK functions in signaling mechanisms are described in the context of ischemia/reperfusion injury. Authors discuss biological effects of pharmacological modulation of JNK by using synthetic and natural compounds in the models of myocardial ischemia/reperfusion. The role of JNK in the mechanisms of pre and postconditioning of the heart is highlighted. Results of experimental studies are demonstrated that JNK represent potential therapeutic targets for cardiac protection from ischemia/reperfusion injury. At the same time, the presence of multiple physiological JNK properties does not allow for systemic use of non specific JNK inhibitors for therapeutic purposes. Authors conclude that the actual problem is the further search for selective JNK3 inhibitors.
About the Authors
M. V. Shvedova
RASA Center in Tomsk, Tomsk Polytechnic University;
Siberian State Medical University
Russian Federation
Tomsk
Russian Federation
Tomsk
Y. Anfinogenova
RASA Center in Tomsk, Tomsk Polytechnic University;
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences;
Siberian State Medical University
Russian Federation
Tomsk
Russian Federation
Tomsk
S. V. Popov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
I. A. Shchepetkin
RASA Center in Tomsk, Tomsk Polytechnic University;
Department of Microbiology and Immunology, Montana State University
Russian Federation
Russian Federation
Tomsk;
Bozeman, Montana, USA
D. N. Atochin
RASA Center in Tomsk, Tomsk Polytechnic University;
Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School
Russian Federation
Russian Federation
Tomsk;
Charlestown, Massachusetts, USA
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Review
For citations:
Shvedova M.V., Anfinogenova Y., Popov S.V., Shchepetkin I.A., Atochin D.N. С-JUN N-TERMINAL KINASES AND THEIR MODULATORS IN MYOCARDIAL ISCHEMIA/REPERFUSION INJURY (REVIEW). Siberian Journal of Clinical and Experimental Medicine. 2016;31(3):7-15. (In Russ.) https://doi.org/10.29001/2073-8552-2016-31-3-7-15
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