THE CHANGE IN THE BALANCE OF FATTY ACIDS IN PATIENTS WITH CORONARY ATHEROSCLEROSIS
https://doi.org/10.29001/2073-8552-2017-32-1-28-30
Abstract
Aim. The aim of the study was to investigate the changes in the balance of fatty acids in patients with coronary heart disease (CHD). Material and Methods. A comparative study of balance of 10 fatty acids was carried out in 40 men, including 30 patients with coronary artery disease and verified coronary angiographic coronary atherosclerosis without acute coronary syndrome and in 10 individuals without CHD. Fatty acids were determined using high performance gas-liquid chromatography. Results. Patients with CHD had a statistically significant increase in the content of palmitic (88.5+3.1mg/DL, which is 2.2 times more), stearic (25.4 mm+0.8 mg/DL, which is 1.6 more), and myristic (3.7 V+0.3 mg/DL, 2.8 times) acids compared with the control group. The levels of monounsaturated fatty acids (MUFAs) changed as follows: the levels of palmitoleic and oleic acids were 2.6 and 1.95 times higher compared with control. The decrease in the fraction of polyunsaturated fatty acids (PUFA) in this group was mainly due to the expense of arachidonic acid (9.07+0.7 mg/DL; by 1.4 times lower in comparison with the corresponding value in the control group). The differences were significant, p<0.01. Conclusion. The study showed that, in coronary atherosclerosis, changes in fatty acid balance consist in a statistically significant increase in palmitic acid, stearic acid, myristic acid, and monounsaturated fatty acids, as well as in a statistically significant decrease in arachidonic acid.
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Review
For citations:
Shramko V.S. THE CHANGE IN THE BALANCE OF FATTY ACIDS IN PATIENTS WITH CORONARY ATHEROSCLEROSIS. Siberian Journal of Clinical and Experimental Medicine. 2017;32(1):28-30. (In Russ.) https://doi.org/10.29001/2073-8552-2017-32-1-28-30
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