Features of pregnancy management with familial hypercholesterolemia: a case report
https://doi.org/10.29001/2073-8552-2025-40-1-159-165
Abstract
Familial hypercholesterolemia is an autosomal dominant disorder of lipid metabolism, leading to an increase in plasma low-density lipoprotein cholesterol, followed by premature atherosclerosis. In women with familial hypercholesterolemia, pregnancy and lactation pose an additional risk due to the association of physiological changes, pre-existing dyslipidemia, and limited therapeutic options and experience. A clinical case of successful management of a pregnant woman with familial hypercholesterolemia against the background of multifocal atherosclerosis with an assessment of the dynamics of the lipid profile at different stages of pregnancy and after childbirth is presented.
About the Authors
E. N. Berezikova
Novosibirsk State Medical University (NSMU)
Russian Federation
Russian Federation
Ekaterina N. Berezikova, Dr. Sci. (Med.), Professor, Internal Diseases Department
52, Krasniy pr., Novosibirsk, 630091
S. N. Shilov
Novosibirsk State Medical University (NSMU)
Russian Federation
Russian Federation
Sergey N. Shilov, Dr. Sci. (Med.), Professor, Pathological Physiology and Clinical Pathophysiology Department
52, Krasniy pr., Novosibirsk, 630091
N. F. Yakovleva
Novosibirsk State Medical University (NSMU)
Russian Federation
Russian Federation
Natalia F. Yakovlevа, Cand. Sci. (Med.), Assistant Professor, Department of Policlinic Therapy and General Medical Practice
52, Krasniy pr., Novosibirsk, 630091
O. V. Tsygankova
Novosibirsk State Medical University (NSMU)
Russian Federation
Russian Federation
Oksana V. Tsygankova, Dr. Sci. (Med.), Professor of the Department of Emergency Therapy with Endocrinology and Occupational Pathology
52, Krasniy pr., Novosibirsk, 630091
N. M. Pasman
National Research Novosibirsk State University (NSU)
Russian Federation
Russian Federation
Natalia M. Pasman, Dr. Sci. (Med.), Professor, Head of the Department of Obstetrics and Gynecology
2, Pirogova str., Novosibirsk 630090
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Review
For citations:
Berezikova E.N., Shilov S.N., Yakovleva N.F., Tsygankova O.V., Pasman N.M. Features of pregnancy management with familial hypercholesterolemia: a case report. Siberian Journal of Clinical and Experimental Medicine. 2025;40(1):159-165. (In Russ.) https://doi.org/10.29001/2073-8552-2025-40-1-159-165
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