INVOLVEMENT OF ENDOGENOUS OPIOID RECEPTOR AGONISTS IN INCREASING CARDIAC RESISTANCE TO THE DAMAGING EFFECTS OF REPERFUSION
https://doi.org/10.29001/2073-8552-2017-32-1-101-103
Abstract
It was found that an intravenous administration of the nonselective of opioid receptor (OR) antagonists naltrexone (5 mg/kg) and also the selective antagonist δ1-OR BNTX (0.7 mg/kg), the selective δ2-OR blocker naltriben (0.3 mg/kg), the κ-selective antagonist nor-binaltorphimine (2 mg/kg), do not affect cardiac reperfusion injury in vivo. It is established that the мselective antagonist CTAP limits infarct size.
About the Author
A. V. Mukhomedzyanov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Mukhomedzyanov A.V. INVOLVEMENT OF ENDOGENOUS OPIOID RECEPTOR AGONISTS IN INCREASING CARDIAC RESISTANCE TO THE DAMAGING EFFECTS OF REPERFUSION. Siberian Journal of Clinical and Experimental Medicine. 2017;32(1):101-103. (In Russ.) https://doi.org/10.29001/2073-8552-2017-32-1-101-103
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