EFFICACY EVALUATION OF NEW LOCAL HEMOSTATIC VANCOMYCIN-CONTAINING AGENT BASED ON OXIDIZED CELLULOSE IN AN EXPERIMENT
https://doi.org/10.29001/2073-8552-2017-32-1-108-111
Abstract
In the paper we presented the first results of an experimental study of the efficacy of a new topical hemostatic vancomycin-containing agent based on oxidized cellulose as a hemostatic agent for preventing median sternotomy complications. The study showed that the use of the new hemostatic agent lowered the intraoperative blood loss in laboratory animals (mini-pigs) in comparison with bone wax; it did not cause clinical and histological signs of inflammation; and it did not inhibit bone regeneration for three weeks after surgery.
About the Authors
A. R. Tarkova
Siberian Biomedical Research Center n.a. E.N. Meshalkin
Russian Federation
Russian Federation
A. M. Chernyavskiy
Siberian Biomedical Research Center n.a. E.N. Meshalkin
Russian Federation
Russian Federation
S. V. Morozov
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
I. A. Grigor’ev
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
N. I. Tkacheva
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
V. I. Rodionov
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Tarkova A.R., Chernyavskiy A.M., Morozov S.V., Grigor’ev I.A., Tkacheva N.I., Rodionov V.I. EFFICACY EVALUATION OF NEW LOCAL HEMOSTATIC VANCOMYCIN-CONTAINING AGENT BASED ON OXIDIZED CELLULOSE IN AN EXPERIMENT. Siberian Journal of Clinical and Experimental Medicine. 2017;32(1):108-111. (In Russ.) https://doi.org/10.29001/2073-8552-2017-32-1-108-111
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