BIOCOMPATIBILITY TESTING OF NATURAL AND SYNTHETIC PERICARDIAL ADHESION BARRIERS
https://doi.org/10.29001/2073-8552-2017-32-1-111-115
Abstract
Here we performed a physicomechanical and biocompatibility testing of pericardial adhesion barriers prepared from either blend of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with poly(lactide-co-glycolide) or collagen. Collagen adhesion barriers had higher durability while synthetic barriers were more prone to deformation. No significant differences in serum levels of proinflammatory cytokines (TNF-б, IL-1в, IL-6, and MCP-1) were found between rats with either collagen or synthetic adhesion barriers implanted to anterior pericardium compared to mock-treated rats. We conclude that both natural and synthetic pericardial adhesion barriers do not cause any systemic inflammation and have high biocompatibility.
About the Authors
D. K. Shishkova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Yu. A. Kudryavtseva
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
M. V. Nasonova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Yu. I. Khodyrevskaya
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
N. N. Burkov
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
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Review
For citations:
Shishkova D.K., Kudryavtseva Yu.A., Nasonova M.V., Khodyrevskaya Yu.I., Burkov N.N. BIOCOMPATIBILITY TESTING OF NATURAL AND SYNTHETIC PERICARDIAL ADHESION BARRIERS. Siberian Journal of Clinical and Experimental Medicine. 2017;32(1):111-115. (In Russ.) https://doi.org/10.29001/2073-8552-2017-32-1-111-115
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