SEARCHING FOR MOLECULAR-GENETIC PREDICTORS OF AGGRESSIVE LYMPHOMAS
https://doi.org/10.29001/2073-8552-2017-32-2-14-17
Abstract
Polymorphic loci of genes of folate metabolism C677T and A1298C MTHFR, A2756G MTR, A66G MTRR, G1958A MTHFD1 and 844ins68 CBS have been studied in patients with aggressive malignant Non Hodgkin lymphomas. The association of a rare allele 1958A MTHFD1 with a reduced risk of enlargement of diffuse large B-cell lymphoma (OR=0.429; C.I. [0.279–0.659], p<0.0008) is found. Impact of other polymorphic loci on susceptibility to enlargement of lymphomas has not been detected yet.
About the Authors
O. V. Berezina
Novosibirsk State Medical University
Russian Federation
Russian Federation
T. I. Pospelova
Novosibirsk State Medical University
Russian Federation
Russian Federation
M. L. Filipenko
Institute of Chemical Biology and Fundamental Medicine of SB RAS
Russian Federation
Russian Federation
E. N. Voropaeva
Institute of Internal and Preventive Medicine
Russian Federation
Russian Federation
V. S. Ovchinnikov
Novosibirsk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Berezina O.V., Pospelova T.I., Filipenko M.L., Voropaeva E.N., Ovchinnikov V.S. SEARCHING FOR MOLECULAR-GENETIC PREDICTORS OF AGGRESSIVE LYMPHOMAS. Siberian Journal of Clinical and Experimental Medicine. 2017;32(2):14-17. (In Russ.) https://doi.org/10.29001/2073-8552-2017-32-2-14-17
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