THE STATE OF OXIDANT-ANTIOXIDANT SYSTEM IN PATIENTS WITH MULTIPLE MYELOMA DURING THE AUTOLOGOUS TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS
https://doi.org/10.29001/2073-8552-2017-32-2-41-44
Abstract
The aim of the study was to investigate the state of oxidant-antioxidant system (OS-AOS) in patients with multiple myeloma (MM) during the autologous hematopoietic stem cells transplantation (autoHSCT). We studied 20 patients (11 men and 9 women, mean age 49 years) who followed autoHSCT after high-dose melphalan. The control group consisted of 50 age- and sex-matched healthy persons. The plasma levels of malonic dialdehyde and cerulloplasmin as well as activities of superoxide dismutase and catalase were measured by standard biochemical techniques. In erythrocytes, the level of non-protein thiol groups was studied. The state of OS-AOS was investigated in each patient four times: before and after conditioning with melphalan, at the moment of maximal leukocyte decrease and after complete reconstitution from cytopenia. We have found the features of impaired balance in OS-AOS in MM patients before as well as in course of autoHSCT. The level of malonic dialdehyde in MM patients was not significantly different from that in the control group. At the same time, cerulloplasmin plasma level as well as catalase activity were significantly increased in patient group (p<0.05), whereas the level of non-protein thiol groups was decreased in MM (p<0.05). The results of our study have shown, that an imbalance of OS-AOS is frequently seen in MM patients and, possibly, could influence the course of autoHSCT.
About the Authors
L. P. Rybakova
Russian Research Institute of Hematology and Transfusiology, Russian Federal Medico-biological Agency
Russian Federation
Russian Federation
L. R. Aleksanyan
Russian Research Institute of Hematology and Transfusiology, Russian Federal Medico-biological Agency
Russian Federation
Russian Federation
S. V. Gritsaev
Russian Research Institute of Hematology and Transfusiology, Russian Federal Medico-biological Agency
Russian Federation
Russian Federation
S. I. Kapustin
Russian Research Institute of Hematology and Transfusiology, Russian Federal Medico-biological Agency
Russian Federation
Russian Federation
S. S. Bessmeltsev
Russian Research Institute of Hematology and Transfusiology, Russian Federal Medico-biological Agency
Russian Federation
Russian Federation
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For citations:
Rybakova L.P., Aleksanyan L.R., Gritsaev S.V., Kapustin S.I., Bessmeltsev S.S. THE STATE OF OXIDANT-ANTIOXIDANT SYSTEM IN PATIENTS WITH MULTIPLE MYELOMA DURING THE AUTOLOGOUS TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS. Siberian Journal of Clinical and Experimental Medicine. 2017;32(2):41-44. (In Russ.) https://doi.org/10.29001/2073-8552-2017-32-2-41-44
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