Preview

Siberian Journal of Clinical and Experimental Medicine

Advanced search

DYNAMIC ELECTRONEUROSTIMULATION IN THE CORRECTION OF BIOCHEMICAL PARAMETERS AND QUALITY OF LIFE IN PATIENTS WITH MULTIPLE MYELOMA

https://doi.org/10.29001/2073-8552-2017-32-2-45-48

Abstract

The biochemical parameters of blood and quality of life were studied in patients with multiple myeloma and peripheral polyneuropathy during treatment with dynamic electroneurostimulation. 106 patients were divided into 3 groups: the 1st group received a standard chemotherapy with a dynamic electroneurostimulation course, the 2nd group was treated with a simulated placebo device, the third one used the standard treatment. In the first group the number of serotonin and dopamine increased in the blood plasma of patients in the 1.3-fold. The epinephrine and insulin number tended to decrease, while the norepinephrine and cortisol concentration increased by 1.2 and 1.3 times respectively. In the comparison group, these values have not changed. Physical functioning, general health and vitality, according to the SF-36, increased by 1.5, 1.7 and 1.5 times in the first group respectively, compared with baseline values that differ from the identical parameters in groups of comparison.

About the Authors

V. A. Drobyshev
Novosibirsk State Medical University
Russian Federation


O. I. Zakhariya
Novosibirsk State Medical University
Russian Federation


References

1. Бессмельцев С.С., Карягина Е.В., Стельмашенко Л.В. и др. Частота, характеристика и методы лечения периферической нейропатии у больных множественной миеломой, получающих бортезомиб (велкейд) // Онкогематология. – 2011. – № 3. – С. 52–62.

2. Дробышев В.А., Чернышев В.В., Малахов В.В. ДЭНС-терапия алгических синдромов при патологии периферической нервной системы // Мед. вестник. – Екатеринбург, 2012.– Т. 2, вып. 3. – С. 24–31.

3. Красовский В.О., Киреева Н.В., Рявкин А.Ю. К вопросу о гомеостазо-модуляторном механизме действия аппаратов ДЭН -терапии // Тез. докл. межрегион. научно-практич. конф. “Электродинамическая рефлексотерапия аппаратами ДЭНС-терапии – новая технология практической медицины”. – СПб., 2012. – С. 14–15.

4. Рявкин С.Ю., Пономаренко Г.Н., Дробышев В.А. и др. Эффективность применения чрескожной электронейростимуляции при дискогенных дорсопатиях поясничной локализации // Вестник восстановительной медицины. – 2012. – № 5. – С. 2–10.

5. Coderre T.J., Katz J., Vaccarino A.L. et al. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence // Pain. – 2012. – Vol. 52. – P. 259–285.

6. Montagut C., Rovira A., Mellado B. et al. Preclinical and clinical development of the proteasome inhibitor bortezomib in cancer treatment // Drugs Today (Barc.). – 2013. – Vol. 41. – P. 299– 315.

7. Багель Г.Е., Гурленя А.М. Физиотерапия в неврологии. – Минск : Вышейшая школа, 2012. – 257 с.

8. Kyle R.A., Rajkumar S.V. Multiplemyeloma // Blood. – 2012. – Vol. 111 (6). – P. 2962–72

9. LudwigH., BolejackV., CrowleyJ. et al. Survival and years of life in different age cohorts of patients with multiple myeloma // J. Clin. Oncol. – 2013. – Vol. 28. – P. 1599–605.

10. Nelson D.L. “5-HT5 receptors”. Current drug targets // CNS and neurological disorders. – 2004. – Vol. 3 (1). – P. 53–8.

11. Катунина Е. А. Агонисты дофаминовых рецепторов и проблема эквивалентности доз // Неврология. – 2010. – № 2.


Review

For citations:


Drobyshev V.A., Zakhariya O.I. DYNAMIC ELECTRONEUROSTIMULATION IN THE CORRECTION OF BIOCHEMICAL PARAMETERS AND QUALITY OF LIFE IN PATIENTS WITH MULTIPLE MYELOMA. Siberian Journal of Clinical and Experimental Medicine. 2017;32(2):45-48. (In Russ.) https://doi.org/10.29001/2073-8552-2017-32-2-45-48

Views: 319


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2713-2927 (Print)
ISSN 2713-265X (Online)