Reparative processes in myocardial infarction: molecular mechanisms and prospects for therapeutic intervention (literature review)
Yu. V. Cheburkin,
E. A. Smirnov,
E. A. Murashko,
A. A. Kolobov,
A. B. Bondarenko,
N. O. Sitkov,
M. M. Galagudza https://doi.org/10.29001/2073-8552-2026-41-3-27-36
Abstract
Post-infarction scar formation after myocardial infarction (MI) is a complex dynamic process involving stages of inflammation, proliferation, and scar maturation. Reparative processes in MI mainly occur during the proliferation stage, including angiogenesis, fibrogenesis, and cardiomyogenesis, the latter characterized by insufficient effectiveness for complete myocardial recovery after irreversible damage. The review summarizes current data on the molecular mechanisms of the reparative response in MI, which involves both resident myocardial cells and leukocytes, stem and progenitor cells recruited from the bloodstream. Growth factors, cytokines, and biologically active substances play an important role in the regulation of cellular processes occurring at the proliferation stage after MI. The local concentration of growth factors in the damaged myocardium, as well as the dynamics of their formation, determine the outcomes of ischemic myocardial damage associated with postinfarct remodeling and the likelihood of developing chronic heart failure. This allows us to consider growth factors, their receptors, and cellular signaling pathways as promising therapeutic targets to prevent adverse outcomes after MI.
Keywords
myocardial infarction,
ischemic injury,
growth factors,
vascular endothelial growth factor,
post-infarction scar,
myocardial remodeling
Supporting agencies: The research was performed at the expense of the state assignment of Almazov National Medical Research Centre “Development of a method of targeted delivery based on nanoconjugates of cardio-targeting peptides” (reg. No. 124021600063-1).
About the Authors
Yu. V. Cheburkin
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation (Almazov National Medical Research Centre); St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation (St. Petersburg State Pediatric Medical University)
Russian Federation
Russian Federation
Yuri V. Cheburkin - Cand. Sci. (Med.), Head of the Research Laboratory, Infectious Pathogens and Biomolecular Nanostructures, Almazov National Medical Research Centre; Associate Professor, Department of Medical Biology, St. Petersburg State Pediatric Medical University.
2, Akkuratova str., Saint Petersburg, 197341; 2, Litovskaya str., Saint Petersburg, 194100
E. A. Smirnov
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation (Almazov National Medical Research Centre); Saint Petersburg Electrotechnical University “LETI”
Russian Federation
Russian Federation
Evgeny A. Smirnov - Junior Research Scientist, Research Laboratory of Infectious Pathogens and Biomolecular Nanostructures, Almazov National Medical Research Centre; Graduate Student, Department of Micro- and Nanoelectronics, Saint Petersburg Electrotechnical University “LETI”.
2, Akkuratova str., Saint Petersburg, 197341; 5, lit. F, Professor Popov str., Saint Petersburg, 197022
E. A. Murashko
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation (Almazov National Medical Research Centre)
Russian Federation
Russian Federation
Ekaterina A. Murashko - Cand. Sci. (Chem.), Head of the Research Laboratory of Metabolomic and Metabolic Profiling; Assistant, Department of Chemistry, Institute of Medical Education, Almazov National Medical Research Centre.
2, Akkuratova str., Saint Petersburg, 197341
A. A. Kolobov
Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical-Biological Agency of the Russian Federation
Russian Federation
Russian Federation
Alexey A. Kolobov - Cand. Sci. (Biol.), Leading Research Scientist, Laboratory of Peptide Chemistry, Research Institute of Hygiene, Occupational Pathology and Human Ecology.
6/2, Bldg 93, Zavodskaya str., g.p. Kuzmolovskii, Vsevolozhsky district, Leningrad Region, 188663
A. B. Bondarenko
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation (Almazov National Medical Research Centre); St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation (St. Petersburg State Pediatric Medical University)
Russian Federation
Russian Federation
Andrey B. Bondarenko - Junior Research Scientist, Research Laboratory of Infectious Pathogens and Biomolecular Nanostructures, Almazov National Medical Research Centre; Senior Lecturer, Department of Medical Biology, St. Petersburg State Pediatric Medical University.
2, Akkuratova str., Saint Petersburg, 197341; 2, Litovskaya str., Saint Petersburg, 194100
N. O. Sitkov
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation (Almazov National Medical Research Centre); Saint Petersburg Electrotechnical University “LETI”
Russian Federation
Russian Federation
Nikita O. Sitkov - Cand. Sci. (Tech.), Leading Research Scientist, Research Laboratory of Infectious Pathogens and Biomolecular Nanostructures, Almazov National Medical Research Centre; Associate Professor, Department of Micro- and Nanoelectronics, Saint Petersburg Electrotechnical University “LETI”.
2, Akkuratova str., Saint Petersburg, 197341; 5, lit. F, Professor Popov str., Saint Petersburg, 197022
M. M. Galagudza
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation (Almazov National Medical Research Centre); Institute for Analytical Instrumentation of the Russian Academy of Sciences (Institute for Analytical Instrumentation)
Russian Federation
Russian Federation
Mikhail M. Galagudza - Dr. Sci. (Med.), Corresponding Member of the RAS, Director of the Institute of Experimental Medicine; Head of the Department of Pathological Physiology, Institute of Medical Education, Almazov National Medical Research Centre; Principal Research Scientist, Institute for Analytical Instrumentation.
2, Akkuratova str., Saint Petersburg, 197341; 31-33, lit. A, Ivan Chernykh str., 198095, Saint Petersburg
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Cheburkin Yu.V., Smirnov E.A., Murashko E.A., Kolobov A.A., Bondarenko A.B., Sitkov N.O., Galagudza M.M. Reparative processes in myocardial infarction: molecular mechanisms and prospects for therapeutic intervention (literature review). Siberian Journal of Clinical and Experimental Medicine. 2026;41(3):27-36. (In Russ.) https://doi.org/10.29001/2073-8552-2026-41-3-27-36
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