CLINICAL AND FUNCTIONAL CHARACTERISTICS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN CONDITIONS OF EXPOSURE TO INDUSTRIAL AEROSOLS

The aim is to study the clinical and functional characteristics and indicators of blood gas composition in workers with chronic obstructive pulmonary disease (COPD) exposed to the effects of industrial aerosols (IA). Material and Methods. The study included 132 patients with a diagnosis of COPD, stage I, category C; 68 were working in conditions of exposure to IA toxico-chemical action, and 64 people had COPD (comparison group which never worked in conditions of exposure to IA). Patients in both groups were divided into 2 subgroups: subgroup 1 — the duration of exposure to IA did not exceed 10 years, 2 — more than 10 years. Spirography was carried out on the device Care Fusion UK 232 Ltd. carbon monoxide (CO) content in exhaled air was determined using gas analyzer CareFusion Smoke check. Determination of blood oxygen saturation was carried out using pulse oximetry method. The content of the partial pressure of carbon dioxide (pCO2 ) and oxygen (pO2 ) in the venous blood were studied by Astrup method. Results. Most smokers were identified in the group exposed to long-term IA. The lowest values of forced expiratory volume in one second, vital capacity and Tiffeneau index were observed among persons exposed to IA differed significantly (p<0.05) from the control group. The highest values of CO and pCO2 , and pO2 were lowest in the group of patients with COPD in the combination of IA and in smokers. Conclusion. The high frequency and long duration of smoking was found out among the workers exposed to IA. Florid violations of wheeze were detected in individuals exposed to IA. As duration of the production contact with IA increasing, more serious violations of gas exchange are formed in patients with COPD. Keywords: chronic obstructive pulmonary disease, pollutants, industrial enterprise, function of external respiration, dyspnea><0.05) from the control group. The highest values of CO and pCO2 , and pO2 were lowest in the group of patients with COPD in the combination of IA and in smokers. Conclusion. The high frequency and long duration of smoking was found out among the workers exposed to IA. Florid violations of wheeze were detected in individuals exposed to IA. As duration of the production contact with IA increasing, more serious violations of gas exchange are formed in patients with COPD.

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