INFLUENCE OF PROPAFENONE ON THE DIASTOLIC FUNCTION OF THE LEFT VENTRICULAR MYOCARDIUM IN HYPERTENSION DISEASE COMPLICATED BY THE PAROSSYSMAL FORM OF АTRIAL FIBRILLATION
https://doi.org/10.29001/2073-8552-2018-33-1-40-44
Abstract
The aim of this work is to assess the effect of propafenone on the diastolic function of the left ventricle in hypertensive disease complicated by paroxysmal atrial fibrillation.
Materials and Methods. The study involved 86 patients with hypertonic disease, complicated by the paroxysmal form of atrial fibrillation. All patients underwent echocardiography with the definition of a set of generally accepted morphofunctional parameters. All patients were divided into 2 groups according to their age characteristics: 41–60 years old and over 60 years old. When included in the study, propafenone was administered at a dose of 600 mg to restore the rhythm, then after restoring the rhythm in it was administered at a dose of 450 mg per day during the year of observation.
Results and Conclusions. Propaphenone preserves the diastolic function of the left ventricle at its initial normal values for hypertensive disease complicated by the paroxysmal form of atrial fibrillation in patients aged 41–60 years and over 60 years. The drug does not cause progression of diastolic left ventricle dysfunction with its initial altered parameters in hypertensive disease complicated by paroxysmal atrial fibrillation.
About the Authors
I. S. Dik
Medical Center «Avicenna», Group of Companies «Mother and Child»
Russian Federation
Russian Federation
Therapist of the Highest Category, Cardiologist of the Highest Category
17/1, Kommunisticheskaya str., Novosibirsk, 630007
V. P. Drobysheva
Novosibirsk State Medical University
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor, Professor of Hospital Therapy Department, Physiotherapy Faculty
52, Krasny prospect, Novosibirsk, 630007
E. L. Poteryaeva
Novosibirsk State Medical University
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor, Head of Department of Emergency Therapy with Endocrinology and Occupational Pathology
52, Krasny prospect, Novosibirsk, 630007
L. A. Parnicova
Medical Center «Avicenna», Group of Companies «Mother and Child»
Russian Federation
Russian Federation
Physician of Functional Diagnostics of the Highest Category, Doctor of Ultrasound of the Highest Category
17/1, Kommunisticheskaya str., Novosibirsk, 630007
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Review
For citations:
Dik I.S., Drobysheva V.P., Poteryaeva E.L., Parnicova L.A. INFLUENCE OF PROPAFENONE ON THE DIASTOLIC FUNCTION OF THE LEFT VENTRICULAR MYOCARDIUM IN HYPERTENSION DISEASE COMPLICATED BY THE PAROSSYSMAL FORM OF АTRIAL FIBRILLATION. Siberian Journal of Clinical and Experimental Medicine. 2018;33(1):40-44. (In Russ.) https://doi.org/10.29001/2073-8552-2018-33-1-40-44
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