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DEFERRED STENT IMPLANTATION IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION AND MASSIVE CORONARY THROMBOSIS

https://doi.org/10.29001/2073-8552-2018-33-2-16-20

Abstract

By researches it is proved that the phenomenon of no-reflow is an independent predictor of remodeling of the left ventricle at the moment. Particular importance in formation of this phenomenon is the fragmentation of a thrombus with distal embolization of small vessels, which often arise as a complication of the percutaneous coronary intervention during the destruction of a thrombus. Attempts to prevent the development of microvascular obstruction led to the creation of delayed stenting.

The Purpose: assessing the efficacy and safety of deferred stent implantation in patients with ST-segment elevation myocardial infarction and massive coronary thrombosis.

Material and Methods. 12 patients with STEMI are included in a research. In the course of emergency coronary angiography was performed a massive thrombosis of the infarct-related coronary artery was observed with TIMI 2–3 blood flow. The emergency stenting wasn’t carried out to these patients, but continued anti-thrombotic therapy within 24 hours. After one day, repeated the coronary angiography was performed and, according to the indications, performed stenting of residual stenosis.

Results. Development of the phenomenon of no-reflow, deaths and coronary events due to reocclusion of the infarctrelated coronary artery at all patients wasn’t observed. Also, all patients had a positive angiographic result in the form of regurgitation of the thrombus as a result of repeated the coronary angiography.

Conclusion. Two-stage revascularization with delayed-on-day stenting with massive thrombosis of the infarct-related coronary artery in patients with acute myocardial infarction combined with aggressive antithrombotic therapy may be use in clinical practice to reduce the risk of developing the no-reflow phenomenon.

About the Authors

Ya. V. Alekseeva
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Alekseeva Yana V. - Postgraduate Student of Emergency Department


E. V. Vyshlov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Vyshlov Evgeny V. - Dr. Sci. (Med.), Leading Researcher of Emergency Department, Cardiology Research Institute, TNRMC, RAS, Associate Professor of the Cardiology Department, Siberian SMU


V. A. Markov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University
Russian Federation

Markov Valentin A. - Dr. Sci. (Med.), PhD, Leading Researcher of Emergency Department



S. V. Demyanov
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Demyanov Sergey V. - Cand. Sci. (Med.), Researcher of Emergency Department


References

1. Third universal definition of myocardial infarction. Eur. Heart J. 2012; 33: 2551–2567.

2. Berg R., Buhari C. Treating and preventing no reflow in the cardiac catheterization laboratory. Current Cardiology Reviews. 2012; 8(3): 209–214.

3. Galasso G., Schiekofer S., Carolina D’Anna, Di Gioia G., Piccolo R., Niglio T., De Rosa R., Strisciuglio T., Cirillo P., Piscione F., Trimarco B. No-Reflow phenomenon: pathophysiology, diagnosis, prevention, and treatment. A review of the current literature and future perspectives. Angiology. 2013; 65: 180–189.

4. Azarov A. V., Semitko S. P., Glezer М. G., Akhramovich R. V., Maloroev A. I., Melnichenko I. S., Atarov G. Y., Lebedev A. V. The results of delayed endovascular intervention in ST elevation acute myocardial infarction due to thrombotic occlusion of coronary artery. Cardiovascular Therapy and Prevention. 2017; 16(1): 40–45 (In Russ).

5. Movsesyants M. Y., Mironkov A. B., Abugov S. A. Primary percutaneous coronary intervention combined with prophylaxis of microcirculatory embolism: results of hospital and long-term observation. Cardiology and Cardiovascular Surgery. 2012; 4(5): 13–17.

6. Iskhakov M. M., Tagirova D. R., Gazizov N. V., Nugaybekova L. A., Sayfutdinov R. G. «No-reflow» Phenomenon: clinical aspects of reperfusion failure. Kazan Medical Journal. 2015; 96(3): 391– 396 (In Russ).

7. Semitko S. P., Analeev A. I., Klimov V. P., Mayskov V. V., Azarov A. V., Gubenko I. M., Karpun N. A. Results of sequential pharmacoinvasive treatment of ST elevation myocardial infarction with massive coronary thrombosis. International Journal of Interventional Cardioangiology. 2013; 35: 70 (In Russ).

8. Gupta S., Gupta M. M. No reflow phenomenon in percutaneous coronary interventions in ST-segment elevation myocardial infarction. Indian Heart Journal. 2016; 68(4): 539–551.

9. Carrick D., Oldroyd K. G., McEntegart M., Haig C., Petrie M. C., Eteiba H., Hood S., Owens C., Watkins S., Layland J., Lindsay M., Peat E., Rae A., Behan M., Sood A., Hillis W. S., Mordi I., Mahrous A., Ahmed N., Wilson R., Lasalle L., Généreux P., Ford I., Berry. A randomized trial of deferred stenting versus immediate stenting to prevent noor slow-reflow in acute ST-segment elevation myocardial infarction (DEFER-STEMI). JACC. 2014; 63(20): 2088–2098.


Review

For citations:


Alekseeva Ya.V., Vyshlov E.V., Markov V.A., Demyanov S.V. DEFERRED STENT IMPLANTATION IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION AND MASSIVE CORONARY THROMBOSIS. Siberian Journal of Clinical and Experimental Medicine. 2018;33(2):16-20. (In Russ.) https://doi.org/10.29001/2073-8552-2018-33-2-16-20

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ISSN 2713-2927 (Print)
ISSN 2713-265X (Online)