THE USING OF POLYPRENOL-CONTAINING DRUG IN PATIENTS WITH ACUTE CORONARY SYNDROME
https://doi.org/10.29001/2073-8552-2018-33-2-21-25
Abstract
The article shows the results of the study using drug Ropren in the patients with acute coronary syndrome. Ropren is a plant drug containing polyprenols — dolichol precursors which take part in dolichol phosphate pathway. The pathology in this pathway leads to disbalance and glycoprotein deficiency. This is the reason of large group of diseases. This study is randomized double blind placebo controlled (No. NCT03122340 at ClinicalTrials.gov). Patients (n=68) with ACS taking standard therapy including atorvastatin 40 mg/day were randomized into to 2 groups: group 1 (n=34) took Ropren 8 drops 3 times per day for 3 week, then 5 drops 3 times per day for 5 weeks; group 2 (n=34) took placebo in the same dose regimen. After two — month therapy there was a positive dynamic (decreasing) in the level of interleukin-6 in the study group whereas in the control group there was no statistically significant change: 4.36 (2.61, 8.95) and 5.5 (3.3; 8.4) pg/ml, respectively (p<0.05). In the group of patients taking Ropren the reduction or cessation of statin was required significantly less than in the placebo group: 3 (8.8%) vs 9 (26.5%), respectively. One patient from the first group had a side effect in the form of gravity in the right hypochondrium. That is why the administration of Ropren in addition to standard therapy is reasonable in patients with ACS.
About the Authors
E. I. Tsoi
Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences
Russian Federation
Russian Federation
Tsoi Ekaterina I. - Postgraduate Student of Department of Emergency Cardiology.
111a, Kievskaya str., Tomsk, 634012
E. V. Vyshlov
Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences
Russian Federation
Russian Federation
Vyshlov Evgenii V. - Dr. Sci. (Med.), Lead Research Associate of Emergency Cardiology.
111a, Kievskaya str., Tomsk, 634012
V. B. Trusov
Medical Department OOO “Solagran”
Russian Federation
Russian Federation
Trusov Vladimir B. - Psychiatrist, Head of Medical Department.
58, Kirova prospect, Tomsk, 634012
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Review
For citations:
Tsoi E.I., Vyshlov E.V., Trusov V.B. THE USING OF POLYPRENOL-CONTAINING DRUG IN PATIENTS WITH ACUTE CORONARY SYNDROME. Siberian Journal of Clinical and Experimental Medicine. 2018;33(2):21-25. (In Russ.) https://doi.org/10.29001/2073-8552-2018-33-2-21-25
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