ASSOCIATION OF ADRENOREACTIVITY WITH THE STAGE OF CHRONIC HEART FAILURE IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTION
https://doi.org/10.29001/2073-8552-2019-34-2-79-83
Abstract
Objective. To identify associations of beta-adrenoreactivity with stage of chronic heart failure (CHF) in patient with previous
myocardial infarction (MI).
Material and Methods. A total of 50 patients with CHF underwent an analysis of adrenoreactivity based on the changes in red blood cell
osmoresistance in the presence of adrenergic blocker to determine the activity of the sympathoadrenal system a year after MI.
Results. Higher levels of beta-adrenoreactivity (β-ARM) were characteristic of patients with CHF of higher gradations: 61.8
(47.5;74.8) с.u. in patients with stage IIA CHF versus 48.7 (39;65.2) с.u. in patients with stage I CHF, p=0.037.
Conclusion. These results may suggest the diagnostic value of the indicator of adrenoreactivity and its possible use as a new
biomarker for assessing the severity of CHF in patients with previous myocardial infarction.
About the Authors
V. A. Aleksandrenko
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Postgraduate Student, Department of Myocardial Pathology
111a, Kievskaya str., Tomsk, 634012, Russian Federation
T. Yu. Rebrova
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Cand. Sci. (Med.), Research Scientist, Laboratory of Molecular and Cellular Pathology and Genetic Testing
111a, Kievskaya str., Tomsk, 634012, Russian Federation
S. A. Afanasiev
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor, Head of the Laboratory of Molecular and Cellular Pathology and Genetic Testing
111a, Kievskaya str., Tomsk, 634012, Russian Federation
A. A. Garganeeva
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor, Head of the Department of Myocardial Pathology
111a, Kievskaya str., Tomsk, 634012, Russian Federation
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Review
For citations:
Aleksandrenko V.A., Rebrova T.Yu., Afanasiev S.A., Garganeeva A.A. ASSOCIATION OF ADRENOREACTIVITY WITH THE STAGE OF CHRONIC HEART FAILURE IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTION. Siberian Journal of Clinical and Experimental Medicine. 2019;34(2):79-83. (In Russ.) https://doi.org/10.29001/2073-8552-2019-34-2-79-83
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